The DOI matches its Crossref record, with a small difference in title or year; 18 of the 18 references it cites were found in a registry or an index.
Differential effect of glucocorticoids on tumour necrosis factor production in mice: up-regulation by early pretreatment with dexamethasone
Open accessAbstract
Glucocorticoids (GC) are well known inhibitors of tumour necrosis factor (TNF) production. We investigated the role of endogenous GC in the regulation of TNF production in mice treated with lipopolysaccharide (LPS) using a pretreatment with dexamethasone (DEX) to down-regulate the hypothalamus-pituitary-adrenal axis (HPA). Short-term DEX pretreatment (up to 12 h before LPS) inhibited TNF production, but earlier (24-48 h) pretreatments potentiated it. This up-regulating effect was not observed in adrenalectomized mice or when GC synthesis was inhibited with cyanoketone (CK). This effect could not be explained only by the suppression of LPS-induced corticosterone (CS) levels induced by DEX, since a 48-h pretreatment potentiated TNF production without affecting LPS-induced CS levels. On the other hand, mice chronically pretreated with DEX were still responsive to its inhibitory effect on TNF production, thus ruling out the possibility of a decreased responsiveness to GC.
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The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain
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Metadata
- Authors
- FANTUZZI, G., DEMURI, M. T., & GHEZZI, P.
- Affiliations
- Mario Negri Institute for Pharmacological Research (IT)
- ORCID
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-04
- Volume
- 96
- Issue
- 1
- Pages
- 166-169
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- PMC
- PMC1534547
- OpenAlex
- W1984571787
- Cited by
- 28
- References
- 18
- Citations by year
- 2025: 1 · 2018: 2 · 2014: 4 · 2013: 1 · 2012: 1
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical & Experimental Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- Funders
- Rensselaer Polytechnic Institute
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- glucocorticoids, TNF-α, dexamethasone, lipopolysaccharide, hypothalamic-pituitary-adrenal axis, corticosterone, adrenalectomy, cyanoketone, glucocorticoid synthesis inhibition, endogenous glucocorticoids, cytokine regulation, pretreatment timing
- MeSH terms
- Adrenalectomy, Animals, Corticosterone, Cyanoketone, Dexamethasone, Lipopolysaccharides, Male, Mice, Inbred Strains, Tumor Necrosis Factor-alpha, Mice
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