The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
How tumour necrosis factor blockers interfere with tuberculosis immunity
Open accessAbstract
Summary: Tumour necrosis factor (TNF) is a potent inflammatory cytokine that plays an important role in immunity to numerous bacterial infections, including Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) in humans. Infliximab, adalimumab, certolizumab pegol and etanercept are anti-TNF agents used to treat a range of inflammatory/autoimmune diseases, such as rheumatoid arthritis. The use of some of these drugs has been linked to reactivation TB. In addition to blocking TNF-mediated immune responses, some anti-TNF drugs have been found to interfere with innate immune responses, such as phagolysosomal maturation and monocyte apoptosis, as well as cell-mediated responses, including interferon-γ secretion by memory T cells, complement-mediated lysis of Mtb-reactive CD8+ T cells and increased regulatory T cell activity. This review summarizes some of the reported effects of TNF blockers on immune cell responses in the context of the observed clinical data on TB reactivation in patients on anti-TNF therapy.
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Cites
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Persistent bacterial infections and persister cells
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Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation
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Metadata
- Authors
- Harris, J., & Keane, J.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-05-18
- Volume
- 161
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W1786795173
- Cited by
- 291
- References
- 77
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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