Cited by 1,243Bacterial Genetics and BiotechnologyBacterial biofilms and quorum sensingAntimicrobial Resistance in Staphylococcus

Persistent bacterial infections and persister cells

Fisher, Robert A., Gollan, Bridget, Helaine, Sophie·2017·Nature Reviews Microbiology

Abstract

Many bacteria can infect and persist inside their hosts for long periods of time. This can be due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective killing by antibiotics. Bacteria can survive antibiotic treatment if they are resistant or tolerant to a drug. Persisters are a subpopulation of transiently antibiotic-tolerant bacterial cells that are often slow-growing or growth-arrested, and are able to resume growth after a lethal stress. The formation of persister cells establishes phenotypic heterogeneity within a bacterial population and has been hypothesized to be important for increasing the chances of successfully adapting to environmental change. The presence of persister cells can result in the recalcitrance and relapse of persistent bacterial infections, and it has been linked to an increase in the risk of the emergence of antibiotic resistance during treatment. If the mechanisms of the formation and regrowth of these antibiotic-tolerant cells were better understood, it could lead to the development of new approaches for the eradication of persistent bacterial infections. In this Review, we discuss recent developments in our understanding of bacterial persisters and their potential implications for the treatment of persistent infections.

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Crossref · 10.1038/nrmicro.2017.42

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155 of 155 references verified0 citation errors · 0 not checkable

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  • Bacterial drug persistence is transient and mediated by phenotypic plasticity rather than genetic alterations.

    “demonstrating that bacterial drug persistence is transient and mediated by phenotypic plasticity rather than genetic alterations (Figure 2A) [31,32].”

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Authors
Fisher, R. A., Gollan, B., & Helaine, S.
Affiliations
Imperial College London (GB)
Venue
Nature Reviews Microbiology
Published
2017-05-22
Volume
15
Issue
8
Pages
453-464
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W2620525720
Cited by
1,243
References
155
Citations by year
2026: 138 · 2025: 163 · 2024: 162 · 2023: 161 · 2022: 157 · 2021: 144 · 2020: 131 · 2019: 97 · 2018: 81 · 2017: 9
FWCI
11.18
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • Spiral (Imperial College London) (submittedVersion)
Funders
Medical Research Council (MR/J006874/1, MR/M009629/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords
persister cells, persistent bacterial infection, antibiotic tolerance, antibiotic resistance, phenotypic heterogeneity, immune evasion, immunosuppression, relapse, growth arrest
MeSH terms
Anti-Bacterial Agents, Bacteria, Bacterial Infections, Humans, Drug Resistance, Multiple, Bacterial

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