An improved mathematical model of human thyroid hormone regulation
Abstract
SUMMARY: 1. A mathematical model has been constructed of human thyroid hormone regulation by the anterior pituitary gland, which takes account of most of the currently available experimental data. 2. Successful simulation of data on the stimulation of thyrotrophin (TSH) secretion by thyrotrophin releasing hormone (TRH) was achieved assuming that the TSH secretion rate is proportional to the logarithm of the concurrent blood TRH level. 3. Data on the regulation of triiodothyronine (T3) secretion by TSH and the inhibition of TSH secretion by thyroid hormones in contrast could not be simulated on the assumption of instantaneous proportional responses. A mixture of proportional and integral control—the latter taking account of the past history of plasma levels of the regulatory hormone—appeared to be operating at both levels. 4. The pituitary gland appears to be more sensitive to a given fractional change in TRH secretion rate than to the same fractional change in T3 plasma concentration.
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Many models focus on various aspects of the HPT axis, but models that specifically simulate the molecular regulations in thyroid follicles are still uncommon.
“While there are many models focusing on various aspects of the HPT axis (180, 273–275), models that specifically simulate the molecular regulations in thyroid follicles are still uncommon.”
From Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion (2022) · cites this paper as [273]
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TSH and thyrotropic agonists: key actors in thyroid homeostasis
Dietrich, J. W., Landgrafe, G., & Fotiadou, E. H. (2012) · Journal of Thyroid Research · doi:10.1155/2012/351864 · Cited by 146 · see citing works
Homeostatic control of the thyroid-pituitary axis: perspectives for diagnosis and treatment
Hoermann, R., Midgley, J. E. M., Larisch, R., & Dietrich, J. W. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00177 · Cited by 143 · see citing works
Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion
Jing, L., & Zhang, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.992883 · Cited by 61 · see citing works
Leow, M. K.-S. (2007) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2007.05.016 · Cited by 53 · see citing works
DIETRICH, J. W., TESCHE, A., PICKARDT, C. R., & MITZDORF, U. (2004) · Cybernetics and Systems · doi:10.1080/01969720490443354 · Cited by 44 · see citing works
- Authors
- SARATCHANDRAN, P., CARSON, E. R., & REEVE, J.
- Affiliations
- City, University of London (GB)
- Corresponding author
- REEVE, J.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1976-09
- Volume
- 5
- Issue
- 5
- Pages
- 473-483
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2026614593
- Cited by
- 21
- References
- 0
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2019: 2 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- thyroid hormone regulation, anterior pituitary, thyrotropin-releasing hormone, triiodothyronine, negative feedback, PI controller, mathematical model
- MeSH terms
- Humans, Models, Biological, Pituitary Gland, Pituitary Gland, Anterior, Thyroid Hormones, Thyrotropin, Thyrotropin-Releasing Hormone, Triiodothyronine
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