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Cited by 53Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsThyroid Cancer Diagnosis and Treatment

A mathematical model of pituitary–thyroid interaction to provide an insight into the nature of the thyrotropin–thyroid hormone relationship

Leow, Melvin Khee-Shing·2007·Journal of Theoretical Biology
DOI 10.1016/j.jtbi.2007.05.016
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Abstract

The mathematical model proposed focuses on the description of the behavior of the interaction between thyrotropin (i.e. thyroid-stimulating hormone (TSH)) and thyroid hormones with the objective of providing a better understanding of the behavior of TSH-T4 relationship in health and in disease. The normal pituitary-thyroid axis is tightly coupled and regulated with a servomechanism. In the physiological situation, any elevation of thyroid hormones will inhibit TSH secretion by the thyrotrophs of the pituitary, which in turn lead to an appropriate reduction in stimulation of the thyroid, accompanied by a decline of thyroid hormones towards normal. Similarly, a decline in thyroid hormones represents a potent input signal that when sensed by the pituitary thyrotrophs, will result in an increase of TSH output by the latter to accelerate the synthesis and secretion of thyroid hormones to drive the state towards normal equilibrium. Using this model, the profound sensitivity of thyrotrophs to feedback by thyroid hormones can be appreciated and understood better in the context of diseases of thyroid hormone excess and deficiency.

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  • Physicians generally prescribe patients the blood test of FT4 and TSH to assess their thyroid condition.

    “Therefore, physicians generally prescribe patients the blood test of FT4 and TSH to assess their thyroid condition (68).”

    From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [68]

  • Models initially assumed an inverse linear correlation between TSH and T4, later changed to a log-linear relationship, which has remained the standard model.

    “Models initially assumed an inverse linear correlation between TSH and T4 (14–17), but following more detailed analysis this was later changed to a log-linear relationship, which has remained the standard model ever since (18–22).”

    From Homeostatic control of the thyroid-pituitary axis: perspectives for diagnosis and treatment (2015) · cites this paper as [18]

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Authors
Leow, M. K.-S.
Affiliations
National University of Singapore (SG)
Corresponding author
Leow, Melvin Khee-Shing
ORCID
Leow, Melvin Khee-Shing
Venue
Journal of Theoretical Biology
Publisher
Elsevier BV
Published
2007-09
Volume
248
Issue
2
Pages
275-287
ISSN
0022-5193 (ISSN-L)
DOI
10.1016/j.jtbi.2007.05.016
OpenAlex
W2000418951
Cited by
53
References
50
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 6 · 2012: 3
FWCI
1.22
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Theoretical Biology (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
pituitary-thyroid axis, thyroid-stimulating hormone, thyroid hormones, negative feedback, thyrotrophs, mathematical model, thyroid hormone excess, thyroid hormone deficiency, homeostatic regulation
MeSH terms
Animals, Homeostasis, Humans, Models, Biological, Thyroid Gland, Thyroid Hormones, Thyrotropin, Feedback, Physiological, Thyrotrophs

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