REDUCTION OF PLASMA TRIIODOTHYRONINE (T3) INDUCED BY PROPRANOLOL
Abstract
SUMMARY: The effect of propranolol on plasma triiodothyronine (T3), thyroxine (T4) and triiodothyronine uptake by Sephadex G‐25 (RT3U%) was studied in fourteen thyrotoxic patients and eight normal volunteers. 40 mg of propranolol as a single oral dose caused significant reduction in total serum T3 which began 60 min after administration. No significant changes were observed in T4 and RT3U% values. Plasma T3 levels remained suppressed during a 5 day course of treatment with propranolol. These results suggest that propranolol has a direct effect on peripheral metabolism of T3 rather than on thyroid hormone secretion.
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There are reports in humans that propranolol and glucocorticoids inhibit T4 to T3 conversion, but data do not indicate these agents increase LT4 requirement in hypothyroid patients.
“Although there are reports in humans that propranolol and glucocorticoids also inhibit T4 to T3 conversion (194,195), there do not seem to be data indicating that these agents increase the requirement for LT4 in hypothyroid patients.”
From Guidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement (2014) · cites this paper as [194]
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Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928 · see citing works
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- Authors
- LOTTI, G., DELITALA, G., DEVILLA, L., ALAGNA, S., & MASALA, A.
- Affiliations
- University of Sassari (IT)
- ORCID
- MASALA, ANTONIO
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 1977-06
- Volume
- 6
- Issue
- 6
- Pages
- 405-410
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W1984875974
- Cited by
- 68
- References
- 18
- Citations by year
- 2024: 2 · 2019: 2 · 2018: 1 · 2016: 3 · 2014: 1 · 2013: 1
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- propranolol, triiodothyronine, thyroxine, thyrotoxicosis, thyroid hormone uptake, beta-adrenergic blockade, thyroid hormone suppression
- MeSH terms
- Adult, Female, Graves Disease, Humans, Male, Propranolol, Thyroxine, Time Factors, Triiodothyronine
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