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Cited by 101Growth Hormone and Insulin-like Growth FactorsThyroid Disorders and TreatmentsPituitary Gland Disorders and Treatments

Growth hormone secretion and plasma somatomedin-c in primary hypothyroidism

CHERNAUSEK, S. D., UNDERWOOD, LOUIS E., UTIGER, R. D., VAN WYK, J. J.·1983·Clinical Endocrinology
DOI 10.1111/j.1365-2265.1983.tb00007.x
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Abstract

The effect of thyroid hormone deficiency on plasma immunoreactive somatomedin-C concentrations, growth hormone (GH) secretion in response to provocative stimuli, and the plasma somatomedin-C response to exogenous GH was studied in patients with primary hypothyroidism. Plasma Somatomedin-C concentrations were below the 95% confidence interval in 11 of 12 hypothyroid patients (mean +/- SD = 0.27 +/- 0.14 U/ml). With thyroid hormone therapy the mean plasma somatomedin-C level increased four-fold (1.00 +/- 0.43 U/ml). The capacity to secrete GH in response to pharmacological agents was impaired in 3 of the 6 hypothyroid patients tested and normal in the remainder. When the same 6 patients were given a single intramuscular injection of GH (0.1 U/kg) plasma somatomedin-C concentrations increased four-fold by 28 h after the injection. The magnitude of the somatomedin-C response was equal to or greater than that reported for euthyroid GH deficient subjects treated similarly. This study shows that plasma somatomedin-C concentrations are diminished by hypothyroidism. The decreased somatomedin-C levels do not appear to result from resistance to the stimulatory effect of GH, but may be either a result of diminished GH secretion or may be due to direct effects of hypothyroidism upon somatomedin production.

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Crossref · 10.1111/j.1365-2265.1983.tb00007.x

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  • Hypothyroidism reduces GH secretion and is correlated with a significant decrease in IGF-1 which normalizes following administration of thyroid hormone in both humans and rodents.

    “Hypothyroidism reduces GH secretion and is correlated with a significant decrease in IGF-1 which normalizes following the administration of thyroid hormone in both humans and rodents (Chernausek et al., 1983;Feldt-Rasmussen 2007b;Giustina and Wehrenberg, 1995;Tsai and Samuels, 1974).”

    From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Chernausek et al., 1983

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Authors
CHERNAUSEK, S. D., UNDERWOOD, L. E., UTIGER, R. D., & VAN WYK, J. J.
Affiliations
University of North Carolina at Chapel Hill (US)
Corresponding author
CHERNAUSEK, S. D.
ORCID
CHERNAUSEK, S. D.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1983-09
Volume
19
Issue
3
Pages
337-344
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.1983.tb00007.x
OpenAlex
W1972209075
Cited by
101
References
29
Citations by year
2025: 1 · 2024: 3 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2013: 2 · 2012: 2
FWCI
5.22
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8964 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
primary hypothyroidism, growth hormone secretion, insulin-like growth factor I, thyroid hormone deficiency, thyroid hormone replacement, growth hormone stimulation test, exogenous growth hormone, growth hormone resistance
MeSH terms
Adolescent, Aged, Arginine, Child, Child, Preschool, Female, Humans, Hypothyroidism, Insulin, Insulin-Like Growth Factor I, Male, Middle Aged, Somatomedins, Growth Hormone, Thyroid Hormones, Thyrotropin, Thyroxine

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