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Cited by 160Adrenal Hormones and DisordersClinical Laboratory Practices and Quality ControlPituitary Gland Disorders and Treatments

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

An audit of the insulin tolerance test in adult subjects in an acute investigation unit over one year

Jones, S. L., Trainer, P. J., Perry, L., Wass, J. A. H., Besser, G. M., Grossman, A.·1994·Clinical Endocrinology
DOI 10.1111/j.1365-2265.1994.tb03793.x
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Abstract

Objective We audited our practice of insulin tolerance testing (ITT) in terms of safety and technical success. We reviewed the results of those tests performed over a 12-month period. By relating peak cortisol response to 0900 h screening cortisol level, we determined whether we could reduce the number of tests performed. Design The results of all ITTs performed on our unit between 1 January and 31 December 1991 were reviewed. Patients and measurements Patients were prescreened by measurement of serum cortisol and thyroxine, and recording of an electrocardiogram. A subnormal serum thyroxine ( Results A total of 161 tests were performed, 135 of which fulfilled our inclusion criteria. The test was technically successful in all but 5 of these; a significant adverse event occurred in one patient with full recovery after reversal of hypoglycaemia. Thirty-two patients had a suboptimal serum cortisol response to hypoglycaemia: screening cortisol level ranged from 128 to 493 nmol/l and 0900 h serum cortisol measured prior to the ITT from 97 to 431 nmol/l. The lowest level of screening cortisol above which all patients would be expected to achieve the normal peak cortisol of 580 nmol/l or over is therefore 494 nmol/l. If this cut-off level had been adopted, 10 (8%) ITTs need not have been performed if their only purpose had been to assess cortisol reserve. Altering the criterion for the necessary peak cortisol to 500 nmol/l did not affect the number of ITTs required. Our lower limit f…

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Crossref · 10.1111/j.1365-2265.1994.tb03793.x

Cites

17 of 17 references verified0 citation errors · 0 not checkable

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Citations

Cites

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  1. Wass J. A. H., 1989, Endocrinology, 492

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Metadata

Authors
Jones, S. L., Trainer, P. J., Perry, L., Wass, J. A. H., Besser, G. M., & Grossman, A.
Affiliations
St Bartholomew's Hospital (GB)
Corresponding author
Grossman, A.
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
1994-07
Volume
41
Issue
1
Pages
123-128
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.1994.tb03793.x
OpenAlex
W1994824546
Cited by
159
References
17
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 4 · 2013: 3 · 2012: 3
FWCI
0.88
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5008 d)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
insulin tolerance test, hypoglycemia, growth hormone response, test safety, test reduction, hypopituitarism, adult patients, adverse events
MeSH terms
Acromegaly, Adenoma, Adolescent, Adult, Female, Humans, Hydrocortisone, Insulin, Male, Medical Audit, Middle Aged, Pituitary Diseases, Pituitary Neoplasms, Pituitary-Adrenal Function Tests, Retrospective Studies, Prolactinoma

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