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Cited by 175Pituitary Gland Disorders and TreatmentsHead and Neck Surgical OncologyMeningioma and schwannoma management

Rathke’s cleft cysts

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Trifanescu, Raluca, Ansorge, Olaf, Wass, John A. H., Grossman, Ashley B., Karavitaki, Niki·2012·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2011.04235.x
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Abstract

Summary: Rathke’s cleft cysts (RCCs) are benign, sellar and/or suprasellar lesions originating from the remnants of Rathke’s pouch. Although a common finding in routine autopsies (12–33% of normal pituitary glands), symptomatic cases are rare and comprise 5–15% of all surgically resected sellar lesions. Small, asymptomatic RCC do not require surgical intervention, and their natural history is not clear. In series of nonoperated presumed RCCs, 26–94% did not progress during follow‐up periods up to 9 years. In symptomatic ones, surgery is indicated, aiming to drain the cyst content and safely remove as much of the capsule as possible. Following surgical intervention, headaches and visual field defects improve or resolve in a significant number of patients (40–100% and 33–100%, respectively) and partial hypopituitarism recovers in 14–50%. Data on relapse rates published in the last 15 years are based on variable follow‐up periods and show wide variation (between 0% and 33%). The lowest relapse rates have been described in reports with relatively short mean observation periods (<3 years), whereas in those with longer follow‐up the relapse rates increase. Most of the relapses occur within 5–6 years, suggesting that follow‐up is required for at least 5 years after surgery. Risk factors for relapse include the presence of squamous metaplasia in the cyst wall, cyst size and the presence of inflammation. Long‐term sufficiently powered studies aiming to clarify the natural history of asymptomatic RCCs and of those relapsing postoperatively are required.

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Research works printed but not linked: 2

  1. [29]29. Zada, G., Kelly, D.F., Cohan, P. et al. (2003) Endonasal transsphe- noidal approach for pituitary adenomas and other sellar lesions: an assessment of efficacy, safety, and patient impressions. Journal of Neurosurgery, 98, 350-358.
  2. [61]61. Bonneville, F., Chiras, J., Cattin, F. et al. (2007) T2 hypointense sig- nal of rathke cleft cyst. AJNR American Journal of Neuroradiology, 28, 397.

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Authors
Trifanescu, R., Ansorge, O., Wass, J. A. H., Grossman, A. B., & Karavitaki, N.
Affiliations
  • Churchill Hospital (GB)
  • John Radcliffe Hospital (GB)
Corresponding author
Karavitaki, Niki
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2012-01-04
Volume
76
Issue
2
Pages
151-160
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2011.04235.x
OpenAlex
W1731930498
Semantic Scholar
8d7596992abc1322402a4e0f53cdbbbe7e328bc4
Cited by
175
References
69
Citations by year
2026: 10 · 2025: 19 · 2024: 20 · 2023: 8 · 2022: 22 · 2021: 15 · 2020: 12 · 2019: 8 · 2018: 14 · 2017: 10 · 2016: 10 · 2015: 13 · 2014: 7 · 2013: 7
FWCI
0.63
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Head and Neck Surgical Oncology
  • Health Sciences › Medicine › Epidemiology › Meningioma and schwannoma management
Keywords
Rathke's cleft cyst, sellar lesions, pituitary cyst, postoperative hypopituitarism, visual field defects, headache, cyst drainage, natural history (disease), recurrence risk factors
MeSH terms
Humans, Recurrence, Central Nervous System Cysts

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