The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Timing of gonadectomy in adult women with complete androgen insensitivity syndrome (CAIS): patient preferences and clinical evidence
Open accessAbstract
Objective Adult women with complete androgen insensitivity syndrome (CAIS) are increasingly likely to defer or decline gonadectomy despite counselling about malignancy risk. The objectives of this study were to review the evidence on the risk of gonadal malignancy in adult women with CAIS and to explore women’s reasons for deferring gonadectomy. Study Design A case series and literature review. Patients Sixteen women with CAIS over the age of 18 years who have elected to defer gonadectomy. Results Sixty‐two relevant papers were identified. Of these, 14 confirmed that tumours had been reported in 98 adults. Taking into account the limitations of combining historic case series, this review estimates a risk of gonadal malignancy of 14% (range 0% and 22%) in adults with CAIS. The most common reasons women offered for deferring gonadectomy included inconvenience of surgery, concern about surgical risk and reluctance to take hormone replacement therapy. Conclusions Perceived benefits for retaining gonads in women with CAIS are prompting more women to keep their gonads in situ. An accurate estimate for adult malignancy risk is unavailable, and the risks currently quoted may be falsely reassuring.
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Cites
Writing Group for the Women's Health Initiative Investigators (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.3.321 · Cited by 15,889
Consensus Statement on Management of Intersex Disorders
Lee, P. A., Houk, C. P., Ahmed, S. F., Hughes, I. A., & in collaboration with the participants in the International Consensus Conference on Intersex organized by the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology (2006) · Pediatrics · doi:10.1542/peds.2006-0738 · Cited by 2,324
Chapron, C., Querleu, D., Bruhat, M. A., Madelenat, P., Fernandez, H., Pierre, F., & Dubuisson, J. B. (1998) · Human Reproduction · doi:10.1093/humrep/13.4.867 · Cited by 406
Cited by
Jung, E. J., Im, D. H., Park, Y. H., Byun, J. M., Kim, Y. N., Jeong, D. H., Sung, M. S., Kim, K. T., An, H. J., Jung, S. J., et al. (2017) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2017.60.4.378 · Cited by 25
Metadata
- Authors
- Deans, R., Creighton, S. M., Liao, L., & Conway, G. S.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2012-04-23
- Volume
- 76
- Issue
- 6
- Pages
- 894-898
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2101745198
- Cited by
- 185
- References
- 3
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Deans, R., Creighton, S. M., Liao, L., & Conway, G. S. (2012). Timing of gonadectomy in adult women with complete androgen insensitivity syndrome (CAIS): patient preferences and clinical evidence. Clinical Endocrinology. https://doi.org/10.1111/j.1365-2265.2012.04330.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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