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Cited by 45Metabolism and Genetic DisordersNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Plasma and Urinary Dopamine: Studies During Fasting and Exercise and in Tetraplegic Man

Christensen, N. J., Mathias, C. J., Frankel, H. L.·1976·European Journal of Clinical Investigation
DOI 10.1111/j.1365-2362.1976.tb00535.x
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Abstract

Dopamine, noradrenaline and adrenaline were measured in plasma and in urine, using double‐isotope derivative techniques, in 46 normal subjects and in 17 tetraplegic patients with physiologically complete cervical spinal cord transections above the sympathetic outflow. Dopamine was present in plasma in normal subjects in a concentration of 0.33 μg/1 ± 0.06 (SEM). Twenty‐four hour urinary excretion of dopamine averaged 248 yg ± 22. There was a significant correlation between the 24 h urinary excretion of dopamine and of noradrenaline. In the normal subjects plasma dopamine and the urinary excretion of dopamine did not change during three days of fasting while urinary excretion of adrenaline increased twofold. In the normal subjects exercise significantly increased plasma dopamine from 0.25 μg/1 to 0.43 μg/1, but significantly decreased the urinary excretion of dopamine. Exercise significantly increased the excretion of noradrenaline. In the tetraplegic patients the plasma dopamine concentration and the urinary excretion of dopamine were lower but not significantly different from the corresponding values in the normal subjects. Plasma noradrenaline and the urinary excretion of noradrenaline and adrenaline were significantly lower in the tetraplegic patients. It is concluded that dopamine is present in human plasma in concentrations similar to that of noradrenaline. Free dopamine in plasma and urine of normal subjects is not dependent on food intake. Urinary dopamine may be derived from circulating dopamine. Urinary dopamine does not necessarily appear to reflect changes in plasma dopamine. The relationship between plasma dopamine and changes in adrenergic nervous activity deserves further investigation.

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Crossref · 10.1111/j.1365-2362.1976.tb00535.x

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Metadata

Authors
Christensen, N. J., Mathias, C. J., & Frankel, H. L.
Affiliations
Aarhus Municipality (DK)
Corresponding author
Christensen, N. J.
ORCID
Venue
European Journal of Clinical Investigation
Publisher
Wiley
Published
1976-02
Volume
6
Issue
1
Pages
403-409
ISSN
  • 0014-2972 (ISSN-L)
  • 1365-2362
DOI
10.1111/j.1365-2362.1976.tb00535.x
OpenAlex
W2067937858
Cited by
45
References
24
Citations by year
2025: 1 · 2022: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2012: 1
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 11836 d)
Locations
  • European Journal of Clinical Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
plasma dopamine, urinary dopamine, norepinephrine, epinephrine, tetraplegia, cervical spinal cord transection, fasting, physical activity, sympathetic outflow
MeSH terms
Adult, Dopamine, Epinephrine, Physical Exertion, Fasting, Female, Humans, Male, Middle Aged, Norepinephrine, Quadriplegia

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