The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Role of the pro‐inflammatory cytokines TNF‐α and IL‐1β in HIV‐associated dementia
Abstract
Human immunodeficiency virus‐1 (HIV‐1)‐infected and immune‐activated macrophages and microglia secrete neurotoxins. Two of these neurotoxins are the pro‐inflammatory cytokines tumour necrosis factor‐α (TNF‐α) and interleukin‐1β (IL‐1β), which are thought to play a major role in inducing neuronal death. Both TNF‐α and IL‐1β increase the permeability of the blood–brain barrier, through which subsequently HIV‐infected monocytes can enter the brain. They both induce over‐stimulation of the NMDA‐receptor via several pathways, resulting in a lethal neuronal increase in Ca 2+levels. Additionally, TNF‐α co‐operates with several other proinflammatory mediators to enhance their toxic effects. Although most research has focused on the neurotoxic effects of TNF‐α and IL‐1β in HAD, there is also evidence that these cytokines can be neuroprotective. In this paper the effect of TNF‐α and IL‐1β on neuronal life and death in HAD is discussed.
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Cited by
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Metadata
- Authors
- Brabers, N. A. C. H., & Nottet, H. S. L. M.
- Venue
- European Journal of Clinical Investigation
- Publisher
- Wiley
- Published
- 2006-06-06
- Volume
- 36
- Issue
- 7
- Pages
- 447-458
- ISSN
- 0014-2972 (ISSN-L)
- 1365-2362
- OpenAlex
- W1753490518
- Cited by
- 265
- References
- 99
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brabers, N. A. C. H., & Nottet, H. S. L. M. (2006). Role of the pro‐inflammatory cytokines TNF‐α and IL‐1β in HIV‐associated dementia. European Journal of Clinical Investigation. https://doi.org/10.1111/j.1365-2362.2006.01657.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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