The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase
Open accessAbstract
Interferons (IFNs) induce antiviral activity in many cell types. The ability of IFN-γ to inhibit replication of ectromelia, vaccinia, and herpes simplex-1 viruses in mouse macrophages correlated with the cells' production of nitric oxide (NO). Viral replication was restored in IFN-γ-treated macrophages exposed to inhibitors of NO synthase. Conversely, epithelial cells with no detectable NO synthesis restricted viral replication when transfected with a complementary DNA encoding inducible NO synthase or treated with organic compounds that generate NO. In mice, an inhibitor of NO synthase converted resolving ectromelia virus infection into fulminant mousepox. Thus, induction of NO synthase can be necessary and sufficient for a substantial antiviral effect of IFN-γ.
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Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
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Biochemistry of nitric oxide and its redox-activated forms
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Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite
Hibbs, J. B., Taintor, R. R., & Vavrin, Z. (1987) · Science · doi:10.1126/science.2432665 · Cited by 1,527
Cited by
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
HOW CELLS RESPOND TO INTERFERONS
Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
Antiviral Actions of Interferons
Samuel, C. E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.4.778-809.2001 · Cited by 2,743
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
Xie, Q. W., Kashiwabara, Y., & Nathan, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37600-7 · Cited by 2,212
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Metadata
- Authors
- Karupiah, G., Xie, Q.-W., Buller, R. M. L., Nathan, C., Duarte, C., & MacMicking, J. D.
- Venue
- Science
- Published
- 1993-09-10
- Volume
- 261
- Issue
- 5127
- Pages
- 1445-1448
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055111778
- Cited by
- 816
- References
- 4
- FWCI
- 20.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Karupiah, G., Xie, Q.-W., Buller, R. M. L., Nathan, C., Duarte, C., & MacMicking, J. D. (1993). Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase. Science. https://doi.org/10.1126/science.7690156
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