The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Genome‐wide histone methylation profile for heart failure
Abstract
Epigenetic alterations are implicated in the development of cardiac hypertrophy and heart failure, but little is known of which epigenetic changes in which regions of the genome play such a role. We now show that trimethylation of histone H3 on lysine‐4 (K4TM) or lysine‐9 (K9TM) is markedly affected in cardiomyocytes in association with the development of heart failure in a rat disease model. High‐throughput pyrosequencing performed with ChIP products for K4TM or K9TM prepared from human left ventricular tissue with retained or damaged function also revealed that protein‐coding genes located in the vicinity of K4TM marks differ between functional and disabled myocytes, yet both sets of genes encode proteins that function in the same signal transduction pathways for cardiac function, indicative of differential K4TM marking during the development of heart failure. However, K9TM mark‐profile was less dependent on the disease status compared to that of K4TM. Our data collectively reveal global epigenetic changes in cardiac myocytes associated with heart failure.
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Cites
Active Genes Are Tri-Methylated at K4 of Histone H3
Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138
Cited by
Mechanistic Pathways of Sex Differences in Cardiovascular Disease
Regitz-Zagrosek, V., & Kararigas, G. (2017) · Physiological Reviews · doi:10.1152/physrev.00021.2015 · Cited by 732
The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy
Wang, Z., Zhang, X.-J., Ji, Y.-X., Zhang, P., Deng, K.-Q., Gong, J., Ren, S., Wang, X., Chen, I., Wang, H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4179 · Cited by 386
Epigenetic regulation: A new frontier for biomedical engineers
Chen, Z., Li, S., Subramaniam, S., Shyy, J. Y.-J., & Chien, S. (2017) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071516-044720 · Cited by 163
Zhu, J.-Y., Fu, Y., Nettleton, M., Richman, A., & Han, Z. (2017) · eLife · doi:10.7554/elife.22617 · Cited by 53
Metadata
- Authors
- Kaneda, R., Takada, S., Yamashita, Y., Choi, Y. L., Nonaka‐Sarukawa, M., Soda, M., Misawa, Y., Isomura, T., Shimada, K., & Mano, H.
- Venue
- Genes to Cells
- Publisher
- Wiley
- Published
- 2008-12-22
- Volume
- 14
- Issue
- 1
- Pages
- 69-77
- ISSN
- 1356-9597 (ISSN-L)
- 1365-2443
- OpenAlex
- W2070100980
- Cited by
- 161
- References
- 1
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kaneda, R., Takada, S., Yamashita, Y., Choi, Y. L., Nonaka‐Sarukawa, M., Soda, M., Misawa, Y., Isomura, T., Shimada, K., & Mano, H. (2009). Genome‐wide histone methylation profile for heart failure. Genes to Cells. https://doi.org/10.1111/j.1365-2443.2008.01252.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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