The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases
Abstract
The grade of a tumour is gauged on the subjective assessment of a number of histopathological parameters. The problems associated with this exercise were viewed from a historical perspective and survival analysis of 447 patients receiving surgery for rectal adenocarcinoma was undertaken. Only deaths from rectal adenocarcinoma were included as events in the survival analysis. Seven grade‐related parameters were scored by one observer. A grading system was constructed using the Cox regression model. The variables in the best‐fitting parsimonious model comprised lymphocytic infiltration, tubule configuration and pattern of growth. Scores were derived from the model and a four grade system was created in which the groups were of similar size. Good reproducibility of the selected histopathological parameters was demonstrated. Grade‐related parameters were then allowed to compete with stage‐related parameters in an overall model of pathological prognostic categories. The parameters selected in the best model were number of affected lymph nodes, the presence of lymphocytic infiltration and extent of spread through bowel wall. A set of five prognostic categories was developed from this model.
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The Measurement of Observer Agreement for Categorical Data
Landis, J. R., & Koch, G. G. (1977) · Biometrics · doi:10.2307/2529310 · Cited by 81,148
Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793
Asymptotically Efficient Rank Invariant Test Procedures
Peto, R., & Peto, J. (1972) · Journal of the Royal Statistical Society. Series A (General) · doi:10.2307/2344317 · Cited by 3,393
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Ishigami, S., Natsugoe, S., Tokuda, K., Nakajo, A., Che, X., Iwashige, H., Aridome, K., Hokita, S., & Aikou, T. (2000) · Cancer · doi:10.1002/(sici)1097-0142(20000201)88:3<577::aid-cncr13>3.0.co;2-v · Cited by 586
Morphology of sporadic colorectal cancer with DNA replication errors
Jass, J. R., Do, K.-A., Simms, L. A., Iino, H., Wynter, C., Pillay, S. P., Searle, J., Radford-Smith, G., Young, J., & Leggett, B. (1998) · Gut · doi:10.1136/gut.42.5.673 · Cited by 466
Self-citationLabianca, R., Beretta, G. D., Kildani, B., Milesi, L., Merlin, F., Mosconi, S., Pessi, M. A., Prochilo, T., Quadri, A., Gatta, G., et al. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.01.010 · Cited by 409
Microsatellite Instability and 8p Allelic Imbalance in Stage B2 and C Colorectal Cancers
Halling, K. C., French, A. J., McDonnell, S. K., Burgart, L. J., Schaid, D. J., Peterson, B. J., Moon-Tasson, L., Mahoney, M. R., Sargent, D. J., O'Connell, M. J., et al. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.15.1295 · Cited by 375
Zlobec, I., & Lugli, A. (2010) · Oncotarget · doi:10.18632/oncotarget.199 · Cited by 331
Metadata
- Authors
- JASS, J. R., ATKIN, W. S., CUZICK, J., BUSSEY, H. J. R., MORSON, B. C., NORTHOVER, J. M. A., & TODD, I. P.
- Venue
- Histopathology
- Publisher
- Wiley
- Published
- 1986-05
- Volume
- 10
- Issue
- 5
- Pages
- 437-459
- ISSN
- 0309-0167 (ISSN-L)
- 1365-2559
- OpenAlex
- W1994359291
- Cited by
- 538
- References
- 3
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. https://app.cochat.ai/papers/10.1111/j.1365-2559.1986.tb02497.x
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- JASS, J. R., ATKIN, W. S., CUZICK, J., BUSSEY, H. J. R., MORSON, B. C., NORTHOVER, J. M. A., & TODD, I. P. (1986). The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology. https://doi.org/10.1111/j.1365-2559.1986.tb02497.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
