The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget
Open accessAbstract
Epithelial mesenchymal transition (EMT) is proposed as a critical mechanism for the acquisition of malignant phenotypes by epithelial cells. In colorectal cancer, tumor cells having undergone EMT are histologically represented by the presence of tumor buds defined as single cells or small clusters of de-differentiated tumor cells at the invasive front. Tumor budding is not a static, histological feature rather it represents a snap-shot of a dynamic process undertaken by an aggressive tumor with the potential to disseminate and metastasize. Strong, consistent evidence shows that tumor budding is a predictor of lymph node metastasis, distant metastatic disease, local recurrence, worse overall and disease-free survival time and an independent prognostic factor. Moreover, the International Union against Cancer (UICC) recognizes tumor budding as a highly relevant, additional prognostic parameter. The aim of this review is to summarize the evidence supporting the implementation of tumor budding into diagnostic pathology and patient management and additionally to illustrate its worthiness as a potential therapeutic target.
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Cites
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CD44: From adhesion molecules to signalling regulators
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Migrating cancer stem cells — an integrated concept of malignant tumour progression
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EMT: When epithelial cells decide to become mesenchymal-like cells
Kalluri, R. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39675 · Cited by 952
The role of epithelial-mesenchymal transition in cancer pathology
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Cited by
Trinh, A., Trumpi, K., De Sousa E Melo, F., Wang, X., de Jong, J. H., Fessler, E., Kuppen, P. J. K., Reimers, M. S., Swets, M., Koopman, M., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0680 · Cited by 180
De Smedt, L., Palmans, S., Andel, D., Govaere, O., Boeckx, B., Smeets, D., Galle, E., Wouters, J., Barras, D., Suffiotti, M., et al. (2017) · British Journal of Cancer · doi:10.1038/bjc.2016.382 · Cited by 163
Metadata
- Authors
- Zlobec, I., & Lugli, A.
- Venue
- Oncotarget
- Publisher
- Impact Journals, LLC
- Published
- 2010-11-28
- Volume
- 1
- Issue
- 7
- Pages
- 651-661
- ISSN
- 1949-2553 (ISSN-L)
- OpenAlex
- W2160120862
- Cited by
- 331
- References
- 69
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zlobec, I., & Lugli, A. (2010). Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget. Oncotarget. https://doi.org/10.18632/oncotarget.199
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
