The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Pathological response following long‐course neoadjuvant chemoradiotherapy for locally advanced rectal cancer
Abstract
Aims : To standardize the pathological analysis of total mesorectal excision specimens of rectal cancer following neoadjuvant chemoradiotherapy for locally advanced disease (T3/T4), including tumour regression. Methods and results : Standardized dissection and reporting was used for 60 patients who underwent total mesorectal excision following long‐course chemoradiotherapy. Tumour regression was scored by two pathologists (K.S., D.G.) using both an established 5‐point tumour regression grade (TRG), and a novel 3‐point grade. Both scores were evaluated for interobserver variability. A complete or near‐complete pathological response (3‐point TRG 1) was found in 10 patients (17%). Using the 5‐point TRG, there was good agreement between both pathologists (κ = 0.64). Using the 3‐point grade, agreement was excellent (κ = 0.84). No disease recurrence has been reported in patients with a complete, or near complete pathological response (3‐point TRG 1), after a mean follow‐up of 22 months. Conclusion : Tumour regression grade is a useful method of scoring tumour response to chemoradiotherapy in rectal cancer. TRG 1 and 2 can be regarded as a complete pathological response (ypT0). A modified 3‐point grade has the advantage of better reproducibility, with similar prognostic significance.
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Cites
Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer
Kapiteijn, E., Marijnen, C. A. M., Nagtegaal, I. D., Putter, H., Steup, W. H., Wiggers, T., Rutten, H. J. T., Pahlman, L., Glimelius, B., van Krieken, J. H. J. M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010580 · Cited by 4,205
Improved Survival with Preoperative Radiotherapy in Resectable Rectal Cancer
(1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361402 · Cited by 2,517
Cited by
Compton, C. C., Byrd, D. R., Garcia-Aguilar, J., Kurtzman, S. H., Olawaiye, A., & Washington, M. K. (2012) · AJCC Cancer Staging Atlas · doi:10.1007/978-1-4614-2080-4_14 · Cited by 395
Trakarnsanga, A., Gönen, M., Shia, J., Nash, G. M., Temple, L. K., Guillem, J. G., Paty, P. B., Goodman, K. A., Wu, A., Gollub, M., et al. (2014) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/dju248 · Cited by 262
Chatterjee, D., Katz, M. H., Rashid, A., Varadhachary, G. R., Wolff, R. A., Wang, H., Lee, J. E., Pisters, P. W. T., Vauthey, J., Crane, C., et al. (2012) · Cancer · doi:10.1002/cncr.26651 · Cited by 260
Nasief, H., Zheng, C., Schott, D., Hall, W., Tsai, S., Erickson, B., & Allen Li, X. (2019) · npj Precision Oncology · doi:10.1038/s41698-019-0096-z · Cited by 181
Pan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade
Stein, J. E., Lipson, E. J., Cottrell, T. R., Forde, P. M., Anders, R. A., Cimino-Mathews, A., Thompson, E. D., Allaf, M. E., Yarchoan, M., Feliciano, J., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2379 · Cited by 177
“Chemotherapy scoring irPRC NSCLC (3, 10) Breast carcinoma (5, 27) Colorectal carcinoma (6, 33) Pan-tumor”
Background
Metadata
- Authors
- Ryan, R., Gibbons, D., Hyland, J. M. P., Treanor, D., White, A., Mulcahy, H. E., O'Donoghue, D. P., Moriarty, M., Fennelly, D., & Sheahan, K.
- Venue
- Histopathology
- Publisher
- Wiley
- Published
- 2005-07-25
- Volume
- 47
- Issue
- 2
- Pages
- 141-146
- ISSN
- 0309-0167 (ISSN-L)
- 1365-2559
- OpenAlex
- W1996916701
- Cited by
- 726
- References
- 2
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pathological response following long‐course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. https://app.cochat.ai/papers/10.1111/j.1365-2559.2005.02176.x
- The paper
- Ryan, R., Gibbons, D., Hyland, J. M. P., Treanor, D., White, A., Mulcahy, H. E., O'Donoghue, D. P., Moriarty, M., Fennelly, D., & Sheahan, K. (2005). Pathological response following long‐course neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Histopathology. https://doi.org/10.1111/j.1365-2559.2005.02176.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
