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Cited by 31Thyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid SurgeryHead and Neck Anomalies

Clinical significance of RET/PTC and p53 protein expression in sporadic papillary thyroid carcinoma

Zafon, C, Obiols, G, Castellví, J, Tallada, N, Baena, J A, Simó, R, Mesa, J·2007·Histopathology
DOI 10.1111/j.1365-2559.2006.02555.x
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Abstract

Aims: Rearranged during Transfection (RET)/papillary thyroid carcinoma (PTC) and p53 are two genes involved in the pathogenesis of PTC. It has been suggested that RET/PTC expression is associated with higher rates of local extension and lymph node involvement, whereas p53 mutations are more frequent in poorly differentiated and anaplastic carcinomas. In addition, experimental studies have shown that p53 activity can modify the behaviour of PTC carrying RET/PTC. The aim of this study was to investigate the expression of both RET/PTC and p53 in order to evaluate their usefulness as prognostic factors. Methods and results: Resected specimens of 61 cases of PTC were studied immunohistochemically using a polyclonal antibody to RET and a monoclonal antibody to p53 protein. RET/PTC expression was associated with extrathyroid extension of PTC, at diagnosis (P < 0.05). In contrast, no relationship between p53 immunoreactivity and clinical status was found. In addition, p53 expression was more prevalent among RET/PTC+ patients, and significantly influenced the relationship observed between RET/PTC and extrathyroid extension of the disease. Conclusion: Our results suggest that immunohistochemistry for both PTC/RET and p53 could be useful in the clinical evaluation of patients with PTC.

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Authors
Zafon, C., Obiols, G., Castellví, J., Tallada, N., Baena, J. A., Simó, R., & Mesa, J.
Affiliations
Vall d'Hebron Hospital Universitari (ES)
Corresponding author
Obiols, G
ORCID
Venue
Histopathology
Publisher
Wiley
Published
2007-01
Volume
50
Issue
2
Pages
225-231
ISSN
  • 0309-0167 (ISSN-L)
  • 1365-2559
DOI
10.1111/j.1365-2559.2006.02555.x
OpenAlex
W2087000480
Cited by
31
References
59
Citations by year
2023: 2 · 2022: 2 · 2019: 1 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
2.69
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2 d)
Locations
  • Histopathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Surgery › Head and Neck Anomalies
Keywords
papillary thyroid carcinoma, RET/PTC rearrangement, p53 expression, prognostic factors, extrathyroidal extension, lymph node metastasis, RET oncogene, TP53 mutation, immunohistochemistry
MeSH terms
Adult, Carcinoma, Female, Humans, Male, Prognosis, Thyroid Neoplasms, Biomarkers, Tumor, Tumor Suppressor Protein p53, Proto-Oncogene Proteins c-ret

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