Allergic inflammatory reaction is involved in necrosis of human pulmonary dirofilariasis
Open accessAbstract
Aims: To determine whether, in view of the massive inflammatory cell infiltration and the rounded rather than wedge‐shaped character of pulmonary lesions in dirofilariasis, the inflammatory response against the worm contributes to the coagulative necrosis, in addition to an ischaemic process. Methods and results: The histopathological features of 13 resected dirofilariasis cases with well‐defined nodules ranged from 10 to 30 mm were analysed. On routine histology and using immunohistochemistry, the peripheral encapsulating wall showed mild to severe infiltration of eosinophils, lymphocytes and plasma cells and a histiocytic reaction in all cases, often with necrotic eosinophils seen within the necrosis (84.6%) and inflammatory changes in the adjacent lung (38.5%). The CD4+ lymphocyte count (80.8 ± 33.4) was greater than that of CD8+ lymphocytes (24.5 ± 16.9) in the central necrosis and vice versa in the wall. In the necrotic regions, disruption of the pulmonary artery (61.5%) and extravasation of the torn worm (23.1%) could be seen. Conclusions: These findings indicate that an allergic inflammatory reaction, mediated by eosinophils and lymphocytes, is involved in the formation of the dirofilarial necrotizing granuloma rather than infarction caused simply by embolism.
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Necrotic regions with pulmonary artery disruption due to exiting worms are frequently observed in pulmonary dirofilariasis.
“Necrotic regions with pulmonary artery disruption due to exiting worms are also frequently observed (12).”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [12]
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Research works printed but not linked: 1
- Marty AM, Neafie RC. Dirofilariasis. In Meyers WM ed. Pathology of infectious diseases. Vol. 1. Helminthiases. Washington, DC: Armed Forces Institute of Pathology, 2000; 275-285.
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Human and animal dirofilariasis: The emergence of a zoonotic mosaic
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- Authors
- Araya, J., Kawabata, Y., Tomichi, N., Kaneko, K., Hayashi, K., Iwabuchi, K., Terasaki, Y., Kawashima, T., & Watanabe, M.
- Affiliations
- Saitama Cardiovascular and Respiratory Center (JP)
- Iwate Prefectural Central Hospital (JP)
- Saitama Red Cross Hospital (JP)
- Tottori University (JP)
- Kitasato University (JP)
- Kumamoto University (JP)
- Toho University (JP)
- Nagano Red Cross Hospital (JP)
- Corresponding author
- Kawabata, Y
- Venue
- Histopathology
- Publisher
- Wiley
- Published
- 2007-09-18
- Volume
- 51
- Issue
- 4
- Pages
- 484-490
- ISSN
- 0309-0167 (ISSN-L)
- 1365-2559
- OpenAlex
- W2056098869
- Cited by
- 10
- References
- 20
- Citations by year
- 2021: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Histopathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Parasitic infections in humans and animals
- Keywords
- pulmonary dirofilariasis, allergic inflammation, coagulative necrosis, eosinophils, CD4+ T cells, CD8+ T cells, granuloma, inflammatory cell infiltration
- MeSH terms
- Adult, Aged, Animals, Dirofilaria, Dirofilariasis, Eosinophils, Female, Histiocytes, Humans, Hypersensitivity, Lung, Lung Diseases, Parasitic, Lymphocytes, Male, Middle Aged, Necrosis
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