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Cited by 32Cancer and Skin LesionsSoft tissue tumor case studiesNonmelanoma Skin Cancer Studies

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Desmoplasia: not always a bad thing

Abbas, Ossama, Mahalingam, Meera·2011·Histopathology
DOI 10.1111/j.1365-2559.2010.03617.x
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Abstract

Desmoplasia describes a histological pattern characterized by a hyalinized stroma and a minimal cellular infiltrate. In non-cutaneous neoplasms, this pattern of stromal response is classically associated with malignancy, whereas in cutaneous pathology, desmoplasia is observed in malignant as well as benign neoplasms. Given this, the obvious question is whether desmoplasia associated with a benign neoplasm is any different from that associated with malignant tumours. Is the stromal response a mere epiphenomenon, or does it actually contribute to the biological behaviour of the neoplasm? What happens at the tumour-host interface? Which molecules are involved in mediating the desmoplastic reaction pattern? This review is an attempt to answer these questions. Examples of benign and malignant cutaneous neoplasms associated with the desmoplastic reaction pattern will be included.

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  • In many cases, the initial apparent expansion of fibroblasts precedes conversion to malignancy, and fibroblasts are often observed circumscribing early or premalignant lesions.

    “In many cases, the initial apparent expansion of fibroblasts precedes the conversion to malignancy, and fibroblasts are often observed circumscribing early or premalignant lesions29,30.”

    From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [30]

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Research works printed but not linked: 107

  1. Barr, 1980, Desmoplastic nevus: a distinct histologic variant of mixed spindle cell and epithelioid cell nevus, Cancer, 46, 557, 10.1002/1097-0142(19800801)46:3<557::AID-CNCR2820460323>3.0.CO;2-L · DOI
  2. Magro, 2006, Unusual variants of malignant melanoma, Mod. Pathol., 19, S41, 10.1038/modpathol.3800516 · DOI
  3. Ferrara, 2009, Desmoplastic nevus: clinicopathologic keynotes, Am. J. Dermatopathol., 31, 718, 10.1097/DAD.0b013e3181a9f0ee · DOI
  4. Huber, 2003, Fibroblast activation protein: differential expression and serine protease activity in reactive stromal fibroblasts of melanocytic skin tumors, J. Invest. Dermatol., 120, 182, 10.1046/j.1523-1747.2003.12035.x · DOI
  5. Kawashiri, 2009, Significance of stromal desmoplasia and myofibroblast appearance at the invasive front in squamous cell carcinoma of the oral cavity, Head Neck, 31, 1346, 10.1002/hed.21097 · DOI
  6. Koperek, 2007, Molecular characterization of the desmoplastic tumor stroma in medullary thyroid carcinoma, Int. J. Oncol., 31, 59
  7. Dolznig, 2005, Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin, Cancer Immun., 5, 10
  8. Huber, 2006, Expression of stromal cell markers in distinct compartments of human skin cancers, J. Cutan. Pathol., 33, 145, 10.1111/j.0303-6987.2006.00446.x · DOI
  9. Longacre, 1996, Desmoplastic and spindle cell melanoma. An immunohistochemical study, Am. J. Surg. Pathol., 20, 1489, 10.1097/00000478-199612000-00008 · DOI
  10. Iacobuzio-Donahue, 2002, The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types, Cancer Res., 62, 5351
  11. Iacobuzio-Donahue, 2002, Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion, Am. J. Pathol., 160, 91, 10.1016/S0002-9440(10)64353-2 · DOI
  12. Tuxhorn, 2002, Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling, Clin. Cancer Res., 8, 2912
  13. Brantsch, 2008, Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study, Lancet Oncol., 9, 713, 10.1016/S1470-2045(08)70178-5 · DOI
  14. Hasebe, 1992, Sebaceous gland and sweat gland carcinomas of the skin. Clinicopathological study and significance of c-erbB-2 oncoprotein expression, Acta Pathol. Jpn., 42, 585
  15. Martín, 2007, Desmoplastic giant congenital nevus with progressive depigmentation, J. Am. Acad. Dermatol., 56, S10, 10.1016/j.jaad.2006.02.021 · DOI
  16. Park, 2000, The influence of the microenvironment on the malignant phenotype, Mol. Med. Today, 6, 324, 10.1016/S1357-4310(00)01756-1 · DOI · Paper page
  17. Liotta, 2001, The microenvironment of the tumour-host interface, Nature, 411, 375, 10.1038/35077241 · DOI
  18. Mueller, 2002, Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells, Differentiation, 70, 486, 10.1046/j.1432-0436.2002.700903.x · DOI
  19. Ruiter, 2002, Melanoma-stroma interactions: structural and functional aspects, Lancet Oncol., 3, 35, 10.1016/S1470-2045(01)00620-9 · DOI
  20. Dvorak, 1986, Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing, N. Engl. J. Med., 315, 1650, 10.1056/NEJM198612253152606 · DOI · Paper page
  21. Barr, 1988, Encapsulation of tumours as a modified wound healing response, Lancet, 2, 135, 10.1016/S0140-6736(88)90686-1 · DOI
  22. Schafer, 2008, Cancer as an overhealing wound: an old hypothesis revisited, Nat. Rev. Mol. Cell Biol., 9, 628, 10.1038/nrm2455 · DOI
  23. Mueller, 2004, Friends or foes-bipolar effects of the tumour stroma in cancer, Nat. Rev. Cancer, 4, 839, 10.1038/nrc1477 · DOI
  24. Geiger, 2009, Metastasis mechanisms, Biochim. Biophys. Acta, 1796, 293
  25. Singh, 2002, ETS proteins and MMPs: partners in invasion and metastasis, Curr. Drug Targets, 3, 359, 10.2174/1389450023347489 · DOI
  26. Myers, 2005, Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer, Clin. Cancer Res., 11, 2111, 10.1158/1078-0432.CCR-04-1192 · DOI
  27. Kalluri, 2006, Fibroblasts in cancer, Nat. Rev. Cancer, 6, 392, 10.1038/nrc1877 · DOI · Paper page
  28. Liu, 2005, Expression and significance of CD44s, CD44v6, and nm23 mRNA in human cancer, World J. Gastroenterol., 11, 6601, 10.3748/wjg.v11.i42.6601 · DOI
  29. Pozdnyakova, 2009, Prognostic value of E-cadherin, beta-catenin, CD44v6, and HER2/neu in metastatic cutaneous adenocarcinoma, Arch. Pathol. Lab. Med., 133, 1285, 10.5858/133.8.1285 · DOI
  30. Lee, 2010, ADAM10 is upregulated in melanoma metastasis compared with primary melanoma, J. Invest. Dermatol., 130, 763, 10.1038/jid.2009.335 · DOI
  31. Walsh, 1988, Desmoplastic malignant melanoma. A clinicopathological study of 14 cases, Arch. Pathol. Lab. Med., 112, 922
  32. Valensi, 1979, Desmoplastic malignant melanoma. A light and electron microscopic study of two cases, Cancer, 43, 1148, 10.1002/1097-0142(197903)43:3<1148::AID-CNCR2820430355>3.0.CO;2-N · DOI
  33. Valensi, 1979, Desmoplastic malignant melanoma. Study of a case by light and electronmicroscopy, J. Dermatol. Surg. Oncol., 5, 31, 10.1111/j.1524-4725.1979.tb00600.x · DOI
  34. Busam, 2005, Distinction of desmoplastic melanoma from non-desmoplastic melanoma by gene expression profiling, J. Invest. Dermatol., 124, 412, 10.1111/j.0022-202X.2004.23600.x · DOI
  35. Michal, 1995, Desmoplastic cellular blue nevus, Am. J. Dermatopathol., 17, 230, 10.1097/00000372-199506000-00003 · DOI
  36. Park, 1999, Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts, J. Biol. Chem., 274, 36505, 10.1074/jbc.274.51.36505 · DOI
  37. Garin-Chesa, 1990, Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers, Proc. Natl Acad. Sci. USA, 87, 7235, 10.1073/pnas.87.18.7235 · DOI
  38. Kojc, 2005, Expression of CD34, alpha-smooth muscle actin, and transforming growth factor beta1 in squamous intraepithelial lesions and squamous cell carcinoma of the larynx and hypopharynx, Hum. Pathol., 36, 16, 10.1016/j.humpath.2004.10.011 · DOI
  39. Kerkelä, 2003, Matrix metalloproteinases in tumor progression: focus on basal and squamous cell skin cancer, Exp. Dermatol., 12, 109, 10.1034/j.1600-0625.2003.120201.x · DOI
  40. Vosseler, 2009, Distinct progression-associated expression of tumor and stromal MMPs in HaCaT skin SCCs correlates with onset of invasion, Int. J. Cancer, 125, 2296, 10.1002/ijc.24589 · DOI
  41. Tsukifuji, 1999, Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis, Br. J. Cancer, 80, 1087, 10.1038/sj.bjc.6690468 · DOI
  42. Miyazono, 2009, Transforming growth factor-beta signaling in epithelial-mesenchymal transition and progression of cancer, Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci., 85, 314, 10.2183/pjab.85.314 · DOI
  43. Bierie, 2006, Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer, Nat. Rev. Cancer, 6, 506, 10.1038/nrc1926 · DOI
  44. Stover, 2007, A delicate balance: TGF-beta and the tumor microenvironment, J. Cell. Biochem., 101, 851, 10.1002/jcb.21149 · DOI
  45. Reed, 1975, Common and uncommon melanocytic nevi and borderline melanomas, Semin. Oncol., 2, 119
  46. Mackie, 1992, The desmoplastic melanocytic naevus: a distinct histological entity, Histopathology, 20, 207, 10.1111/j.1365-2559.1992.tb00958.x · DOI
  47. Harris, 1999, Desmoplastic (sclerotic) nevus: an underrecognized entity that resembles dermatofibroma and desmoplastic melanoma, Am. J. Surg. Pathol., 23, 786, 10.1097/00000478-199907000-00006 · DOI
  48. Paniago-Pereira, 1978, Nevus of large spindle and/or epithelioid cells (Spitz’s nevus), Arch. Dermatol., 114, 1811, 10.1001/archderm.114.12.1811 · DOI
  49. Requena, 2009, Spitz nevus: a clinicopathological study of 349 cases, Am. J. Dermatopathol., 31, 107, 10.1097/DAD.0b013e3181934218 · DOI
  50. Ferrara, 2005, The spectrum of Spitz nevi: a clinicopathologic study of 83 cases, Arch. Dermatol., 141, 1381, 10.1001/archderm.141.11.1381 · DOI
  51. Lazzaro, 1993, Immunophenotyping of compound and Spitz nevi and vertical growth phase melanomas using a panel of monoclonal antibodies reactive in paraffin sections, J. Invest. Dermatol., 100, 313S, 10.1038/jid.1993.54 · DOI
  52. Bergman, 2000, A comparative immunohistochemical study of MART-1 expression in Spitz nevi, ordinary melanocytic nevi, and malignant melanomas, J. Am. Acad. Dermatol., 42, 496, 10.1016/S0190-9622(00)90226-3 · DOI
  53. Rongioletti, 2003, Sclerosing ‘mucinous’ blue naevus, Br. J. Dermatol., 148, 1250, 10.1046/j.1365-2133.2003.05353.x · DOI
  54. Hogan, 1988, Spontaneous resolution of a giant congenital melanocytic nevus, Pediatr. Dermatol., 5, 170, 10.1111/j.1525-1470.1988.tb01164.x · DOI
  55. Ruiz-Maldonado, 2003, Desmoplastic hairless hypopigmented naevus: a variant of giant congenital melanocytic naevus, Br. J. Dermatol., 148, 1253, 10.1046/j.1365-2133.2003.05354.x · DOI
  56. Bushby, 2005, Spontaneous resolution of a giant melanocytic naevus involving a desmoplastic process, Br. J. Dermatol., 153, 13
  57. Pattee, 2001, Giant congenital nevus with progressive sclerodermiform reaction in a newborn, Pediatr. Dermatol., 18, 321, 10.1046/j.1525-1470.2001.01938.x · DOI
  58. Brownstein, 1977, Desmoplastic trichoepithelioma, Cancer, 40, 2979, 10.1002/1097-0142(197712)40:6<2979::AID-CNCR2820400633>3.0.CO;2-8 · DOI
  59. Macdonald, 1977, Sclerosing epithelial hamartoma, Clin. Exp. Dermatol., 2, 153, 10.1111/j.1365-2230.1977.tb01559.x · DOI
  60. Dervan, 1985, Solitary familial desmoplastic trichoepithelioma. A study by conventional and electron microscopy, Am. J. Dermatopathol., 7, 277, 10.1097/00000372-198506000-00011 · DOI
  61. Costache, 2008, Desmoplastic trichoepithelioma versus morphoeic basal cell carcinoma: a critical reappraisal of histomorphological and immunohistochemical criteria for differentiation, Histopathology, 52, 865, 10.1111/j.1365-2559.2008.03036.x · DOI
  62. Hunt, 1990, Desmoplastic trichilemmoma: histologic variant resembling invasive carcinoma, J. Cutan. Pathol., 17, 45, 10.1111/j.1600-0560.1990.tb01677.x · DOI
  63. Tellechea, 1992, Desmoplastic trichilemmoma, Am. J. Dermatopathol., 14, 107, 10.1097/00000372-199204000-00004 · DOI
  64. Illueca, 1998, Diagnostic value of CD34 immunostaining in desmoplastic trichilemmoma, J. Cutan. Pathol., 25, 435, 10.1111/j.1600-0560.1998.tb01770.x · DOI
  65. Tardío, 2009, CD34-reactive tumors of the skin. An updated review of an ever-growing list of lesions, J. Cutan. Pathol., 36, 89, 10.1111/j.1600-0560.2008.01212.x · DOI
  66. Cribier, 1995, Tumor of the follicular infundibulum: a clinicopathologic study, J. Am. Acad. Dermatol., 33, 979, 10.1016/0190-9622(95)90290-2 · DOI
  67. Mahalingam, 2001, Tumor of the follicular infundibulum with sebaceous differentiation, J. Cutan. Pathol., 28, 314, 10.1034/j.1600-0560.2001.028006314.x · DOI
  68. Abbas, 2009, Tumor of the follicular infundibulum: an epidermal reaction pattern?, Am. J. Dermatopathol., 31, 626, 10.1097/DAD.0b013e31819c8608 · DOI
  69. Starink, 1985, The cutaneous pathology of Cowden’s disease: new findings, J. Cutan. Pathol., 12, 83, 10.1111/j.1600-0560.1985.tb01607.x · DOI
  70. Rapini, 1989, Golitz LE: Sclerotic fibromas of the skin, J. Am. Acad. Dermatol., 20, 266, 10.1016/S0190-9622(89)70033-5 · DOI
  71. Wilk, 1995, Sclerotic fibroma, Hautarzt, 46, 413, 10.1007/s001050050275 · DOI
  72. Lisovsky, 2008, Apolipoprotein D in CD34-positive and CD34-negative cutaneous neoplasms: a useful marker in differentiating superficial acral fibromyxoma from dermatofibrosarcoma protuberans, Mod. Pathol., 21, 31, 10.1038/modpathol.3800971 · DOI
  73. Huang, 2002, Superficial collagenous fibroma: immunohistochemical, ultrastructural, and flow cytometric study of three cases, including one pemphigus vulgaris patient with a dermal mass, APMIS, 110, 283, 10.1034/j.1600-0463.2002.100402.x · DOI
  74. Evans, 1995, Desmoplastic fibroblastoma, Am. J. Surg. Pathol., 19, 1077, 10.1097/00000478-199509000-00012 · DOI
  75. Junkins-Hopkins, 1998, Desmoplastic fibroblastoma, J. Cutan. Pathol., 25, 450, 10.1111/j.1600-0560.1998.tb01773.x · DOI
  76. Takahara, 2008, Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermis, J. Cutan. Pathol., 35, 70, 10.1111/j.1600-0560.2007.00964.x · DOI
  77. Pulitzer, 1985, Nerve-sheath myxoma (perineurial myxoma), Am. J. Dermatopathol., 7, 409, 10.1097/00000372-198510000-00003 · DOI
  78. Mahalingam, 2006, Multiple cellular neurothekeomas-a case report and review on the role of immunohistochemistry as a histologic adjunct, J. Cutan. Pathol., 33, 51, 10.1111/j.0303-6987.2006.00400.x · DOI
  79. Hornick, 2007, Cellular neurothekeoma: detailed characterization in a series of 133 cases, Am. J. Surg. Pathol., 31, 329, 10.1097/01.pas.0000213360.03133.89 · DOI
  80. Zedek, 2009, Desmoplastic cellular neurothekeoma: clinicopathological analysis of twelve cases, J. Cutan. Pathol., 36, 1185, 10.1111/j.1600-0560.2009.01263.x · DOI
  81. Fetsch, 1997, Sclerosing perineurioma: a clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults, Am. J. Surg. Pathol., 21, 1433, 10.1097/00000478-199712000-00005 · DOI
  82. Rubin, 2009, Multiple cutaneous sclerosing perineuriomas: an extensive presentation with involvement of the bilateral upper extremities, J. Cutan. Pathol., 36, 60, 10.1111/j.1600-0560.2008.01217.x · DOI
  83. Hunt, 1991, Microvenular hemangioma, J. Cutan. Pathol., 18, 235, 10.1111/j.1600-0560.1991.tb01229.x · DOI
  84. Aloi, 1993, Microvenular hemangioma, Am. J. Dermatopathol., 15, 534, 10.1097/00000372-199312000-00003 · DOI
  85. George, 2009, Subclassification of desmoplastic melanoma: pure and mixed variants have significantly different capacities for lymph node metastasis, J. Cutan. Pathol., 36, 425, 10.1111/j.1600-0560.2008.01058.x · DOI
  86. Lens, 2005, Desmoplastic malignant melanoma: a systematic review, Br. J. Dermatol., 152, 673, 10.1111/j.1365-2133.2005.06462.x · DOI
  87. de, 2008, Desmoplastic malignant melanoma: a clinicopathologic analysis of 113 cases, Am. J. Dermatopathol., 30, 207, 10.1097/DAD.0b013e3181716e6b · DOI
  88. Radfar, 2006, NGFR-positive desmoplastic melanomas with focal or absent S-100 staining: further evidence supporting the use of both NGFR and S-100 as a primary immunohistochemical panel for the diagnosis of desmoplastic melanomas, Am. J. Dermatopathol., 28, 162, 10.1097/01.dad.0000183696.46573.ee · DOI
  89. Breuninger, 1997, Desmoplastic squamous cell carcinoma of skin and vermilion surface: a highly malignant subtype of skin cancer, Cancer, 79, 915, 10.1002/(SICI)1097-0142(19970301)79:5<915::AID-CNCR7>3.0.CO;2-A · DOI
  90. Seal, 2008, Desmoplastic squamous cell carcinoma: case presentation and literature review, J. Cutan. Med. Surg., 12, 243, 10.2310/7750.2008.07047 · DOI
  91. Morgan, 2008, Immunohistochemical distinction of cutaneous spindle cell carcinoma, Am. J. Dermatopathol., 30, 228, 10.1097/DAD.0b013e31816de820 · DOI
  92. Dotto, 2006, p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma, J. Cutan. Pathol., 33, 413, 10.1111/j.0303-6987.2006.00477.x · DOI
  93. Petter, 2000, Histologic subtyping and malignancy assessment of cutaneous squamous cell carcinoma, Dermatol. Surg., 26, 521, 10.1046/j.1524-4725.2000.99181.x · DOI
  94. Litzow, 1968, Morpheaform basal cell carcinoma, Am. J. Surg., 116, 499, 10.1016/0002-9610(68)90382-6 · DOI
  95. Carra, 2007, Basaloid skin tumours: basal cell carcinoma, Curr. Diagn. Pathol., 13, 252, 10.1016/j.cdip.2007.05.005 · DOI
  96. Jones, 2009, Keloidal basal cell carcinoma: not a distinctive clinicopathological entity, Br. J. Dermatol., 160, 127, 10.1111/j.1365-2133.2008.08828.x · DOI
  97. Goldstein, 1982, Microcystic adnexal carcinoma: a distinct clinicopathologic entity, Cancer, 50, 566, 10.1002/1097-0142(19820801)50:3<566::AID-CNCR2820500330>3.0.CO;2-Q · DOI
  98. Sebastien, 1993, Microcystic adnexal carcinoma, J. Am. Acad. Dermatol., 29, 840, 10.1016/0190-9622(93)70251-N · DOI
  99. Hoang, 2008, Microcystic adnexal carcinoma: an immunohistochemical reappraisal, Mod. Pathol., 21, 178, 10.1038/modpathol.3801000 · DOI
  100. Carvalho, 2007, The expression of CD23 in cutaneous non-lymphoid neoplasms, J. Cutan. Pathol., 34, 693, 10.1111/j.1600-0560.2006.00685.x · DOI
  101. Karroum, 1995, Sclerotic primary cutaneous leiomyosarcoma, Am. J. Dermatopathol., 17, 292, 10.1097/00000372-199506000-00013 · DOI
  102. Diaz-Cascajo, 2000, Desmoplastic leiomyosarcoma of the skin, Am. J. Dermatopathol., 22, 251, 10.1097/00000372-200006000-00008 · DOI
  103. Choy, 2006, Primary cutaneous diffuse leiomyosarcoma with desmoplasia, Australas. J. Dermatol., 47, 291, 10.1111/j.1440-0960.2006.00298.x · DOI
  104. Berzal-Cantalejo, 2006, Desmoplastic cutaneous leiomyosarcoma: case report and review of the literature, J. Cutan. Pathol., 33, 29, 10.1111/j.1600-0560.2006.00542.x · DOI
  105. Kaneishi, 1998, Histologic differentiation of desmoplastic melanoma from cicatrices, Am. J. Dermatopathol., 20, 128, 10.1097/00000372-199804000-00004 · DOI
  106. Saeed, 2004, Cutaneous metastasis: a clinical, pathological, and immunohistochemical appraisal, J. Cutan. Pathol., 31, 419, 10.1111/j.0303-6987.2004.00207.x · DOI
  107. Sariya, 2007, Clinicopathologic correlation of cutaneous metastases: experience from a cancer center, Arch. Dermatol., 143, 613, 10.1001/archderm.143.5.613 · DOI

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Metadata

Authors
Abbas, O., & Mahalingam, M.
Affiliations
Boston University (US)
ORCID
Venue
Histopathology
Publisher
Wiley
Published
2010-08-16
Volume
58
Issue
5
Pages
643-659
ISSN
0309-0167 (ISSN-L)
DOI
10.1111/j.1365-2559.2010.03617.x
OpenAlex
W1526847097
Cited by
32
References
0
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 2
FWCI
0.28
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1842 d)
Locations
  • Histopathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
  • Health Sciences › Medicine › Oncology › Soft tissue tumor case studies
  • Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Keywords
desmoplasia, tumor microenvironment, tumor biological behavior
MeSH terms
Animals, Extracellular Matrix, Fibroblasts, Humans, Neoplasms, Skin Neoplasms, Stromal Cells

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