The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice
Open accessAbstract
The vitamin D receptor (VDR) is a nuclear receptor expressed in a number of different cells of the immune system. This study was performed to determine the effect of VDR deficiency on immune function and inflammation of the gastrointestinal tract in a model of inflammatory bowel disease, namely interleukin-10 (IL-10) knockout mice. IL-10 knockout mice were generated which either could or could not respond to vitamin D (double IL-10/VDR knockout; DKO). The distribution and function of lymphocytes in both the primary and secondary lymphoid organs were compared and determined as a function of the severity of intestinal inflammation. DKO mice had normal thymic development and peripheral T-cell numbers at 3 weeks of age, but a week after intestinal disease was detected the thymus was dysplastic with a reduction in cellularity. The atrophy was coupled with increased apoptosis. The spleen weight of DKO mice increased as a result of the accumulation of red blood cells; however, there was a 50% reduction in the numbers of T and B cells. Conversely, the mesenteric lymph nodes were enlarged and contained increased numbers of lymphocytes. The T cells from DKO mice were of a memory phenotype and were hyporesponsive to T-cell receptor stimulation. Colitis in the DKO mice was associated with local and high expression of IL-2, interferon-gamma, IL-1beta, tumour necrosis factor-alpha and IL-12. The primary and secondary lymphoid organs in DKO mice are profoundly altered as a consequence of the fulminating inflammation in the gastrointestinal tract. VDR expression is required for the T cells and other immune cells to control inflammation in the IL-10 KO mice.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Taking 1 g of vitamin C or 533 mg of a-tocopherol before consuming a high-fat test meal blunted the acute CRP response to the meal (781) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [781]
Citations
Cites
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
The immunological and genetic basis of inflammatory bowel disease
Bouma, G., & Strober, W. (2003) · Nature reviews. Immunology · doi:10.1038/nri1132 · Cited by 1,796
Calcium signaling mechanisms in T lymphocytes.
Lewis, R. S. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.497 · Cited by 860
T-cell development and the CD4–CD8 lineage decision
Germain, R. N. (2002) · Nature reviews. Immunology · doi:10.1038/nri798 · Cited by 813
Vitamin D: its role and uses in immunology 1
DeLuca, H. F., & Cantorna, M. T. (2001) · The FASEB Journal · doi:10.1096/fj.01-0433rev · Cited by 784
Self-citationCantorna, M. T., Munsick, C., Bemiss, C. J., & Mahon, B. D. (2000) · Journal of Nutrition · doi:10.1093/jn/130.11.2648 · Cited by 495
Self-citationInhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol).
Rigby, W., Stacy, T. P., & Fanger, M. W. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111557 · Cited by 471
A Crucial Role for the Vitamin D Receptor in Experimental Inflammatory Bowel Diseases
Froicu, M., Weaver, V. C., Wynn, T. A., McDowell, M. A., Welsh, J., & Cantorna, M. T. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0281 · Cited by 407
Self-citationZuckerman, S. H., Shellhaas, J. L., & Butter, L. D. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190213 · Cited by 325
Immunomodulatory role of 1,25‐dihydroxyvitamin D 3
Lemire, J. M. (1992) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240490106 · Cited by 303
Cited by
Sorted by citations
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., & Demay, M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0004 · Cited by 1,783
Epidemiology and risk factors for IBD
Ananthakrishnan, A. N. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.34 · Cited by 1,741
Vitamin D: modulator of the immune system
Baeke, F., Takiishi, T., Korf, H., Gysemans, C. A., & Mathieu, C. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.04.001 · Cited by 1,333
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Primary Prevention of Colorectal Cancer
Chan, A. T., & Giovannucci, E. L. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.057 · Cited by 758
Metadata
- Authors
- Froicu, M., Zhu, Y., & Cantorna, M. T.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Cantorna, Margherita T.
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2006-02-13
- Volume
- 117
- Issue
- 3
- Pages
- 310-318
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- PMC
- PMC1782241
- OpenAlex
- W2101825351
- Cited by
- 128
- References
- 30
- Citations by year
- 2026: 2 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 2 · 2020: 6 · 2019: 9 · 2018: 5 · 2017: 5 · 2016: 10 · 2015: 11 · 2014: 9 · 2013: 7 · 2012: 5
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS038888)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- vitamin D receptor, IL-10 knockout mice, inflammatory bowel disease, colitis, intestinal immunity, thymic atrophy, T cell hyporesponsiveness, mesenteric lymph nodes, lymphocyte distribution, secondary lymphoid organs, cytokine expression, thymic apoptosis
- MeSH terms
- Animals, Atrophy, Colon, Disease Models, Animal, Flow Cytometry, Lymphoid Tissue, Mice, Inbred C57BL, Thymus Gland, Inflammatory Bowel Diseases, T-Lymphocyte Subsets, Cytokines, Interleukin-10, Apoptosis, Receptors, Calcitriol, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
