The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Interleukin‐17 in host defence against bacterial, mycobacterial and fungal pathogens
Open accessAbstract
Summary: The mammalian immune system is intricately regulated, allowing for potent pathogen‐specific immunity to be rapidly activated in response to infection with a broad and diverse array of potential pathogens. As a result of their ability to differentiate into distinct effector lineages, CD4 T cells significantly contribute to pathogen‐specific adaptive immune responses. Through the production of effector cytokines, CD4 T helper (Th) cells orchestrate the precise mobilization of specific immune cells to eradicate infection. The protective effects of the newly identified lineage of Th17 cells against pathogens like Klebsiella pneumoniae, Citrobacter rodentium and Candida albicans indicate the capacity of Th17 cells to confer protection against extracellular bacterial and fungal pathogens, filling a critical void in host immunity not covered by the classically described Th1 lineage that activates immunity to intracellular pathogens or the Th2 lineage that is important in protection against mucosal parasitic pathogens. Host defence by Th17 cells extends beyond protection against extracellular bacterial and fungal pathogens, as demonstrated in infections against intracellular bacteria like Listeria monocytogenes and Salmonella enterica, as well as Mycobacterium tuberculosis. Herein, we summarize both experimental data from mouse infection models and epidemiological studies in humans that demonstrate the protective effects of interleukin‐17 and Th17 CD4 T cells in immunity to bacterial, mycobacterial and fungal pathogens.
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Transforming growth factor-β induces development of the TH17 lineage
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Interleukin-17 Family Members and Inflammation
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Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
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IL-17 family cytokines and the expanding diversity of effector T cell lineages
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Cited by
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
The light and dark sides of intestinal intraepithelial lymphocytes
Cheroutre, H., Lambolez, F., & Mucida, D. (2011) · Nature Reviews Immunology · doi:10.1038/nri3007 · Cited by 693
Kisand, K., Bøe Wolff, A. S., Podkrajšek, K. T., Tserel, L., Link, M., Kisand, K. V., Ersvaer, E., Perheentupa, J., Erichsen, M. M., Bratanic, N., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091669 · Cited by 677
Host–Bacterial Symbiosis in Health and Disease
Chow, J., Lee, S. M., Shen, Y., Khosravi, A., & Mazmanian, S. K. (2010) · Advances in Immunology · doi:10.1016/b978-0-12-381300-8.00008-3 · Cited by 469
Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults
Kollmann, T. R., Crabtree, J., Rein-Weston, A., Blimkie, D., Thommai, F., Wang, X. Y., Lavoie, P. M., Furlong, J., Fortuno, E. S., Hajjar, A. M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901481 · Cited by 466
Metadata
- Authors
- Curtis, M. M., & Way, S. S.
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2009-01-05
- Volume
- 126
- Issue
- 2
- Pages
- 177-185
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- OpenAlex
- W2110730271
- Cited by
- 502
- References
- 78
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- green
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