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Cited by 89Mast cells and histamineNeuropeptides and Animal PhysiologyAntimicrobial Peptides and Activities

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Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines: Catestatin activates human mast cells

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Aung, Gyi, Niyonsaba, François, Ushio, Hiroko, Kajiwara, Naoki, Saito, Hirohisa, Ikeda, Shigaku, Ogawa, Hideoki, Okumura, Ko·2011·Immunology
DOI 10.1111/j.1365-2567.2010.03395.xPMC PMC3075506
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Abstract

Catestatin, a neuroendocrine peptide with effects on human autonomic function, has recently been found to be a cutaneous antimicrobial peptide. Human catestatin exhibits three single nucleotide polymorphisms: Gly364Ser, Pro370Leu and Arg374Gln. Given reports indicating that antimicrobial peptides and neuropeptides induce mast cell activation, we postulated that catestatin might stimulate numerous functions of human mast cells, thereby participating in the regulation of skin inflammatory responses. Catestatin and its naturally occurring variants caused the human mast cell line LAD2 and peripheral blood-derived mast cells to migrate, degranulate and release leukotriene C(4) and prostaglandins D(2) and E(2). Moreover, catestatins increased intracellular Ca(2+) mobilization in mast cells, and induced the production of pro-inflammatory cytokines/chemokines such as granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein-1/CCL2, macrophage inflammatory protein-1α/CCL3 and macrophage inflammatory protein-1β/CCL4. Our evaluation of possible cellular mechanisms suggested that G-proteins, phospholipase C and the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) are involved in catestatin-induced mast cell activation as evidenced by the inhibitory effects of pertussis toxin (G-protein inhibitor), U-73122 (phospholipase C inhibitor) and U0126 (ERK inhibitor), respectively. We also found that human mast cells express the α7 subunit of the nicotinic acetylcholine receptor at both the mRNA and protein levels. Given that silencing the α7 receptor mRNA and an α7-specific inhibitor did not affect catestatin-mediated activation of mast cells, however, we concluded that this receptor is not likely to be functional in human mast cell stimulation by catestatins. Our finding that the neuroendocrine antimicrobial peptide catestatin activates human mast cells suggests that this peptide might have immunomodulatory functions, and provides a new link between neuroendocrine and cutaneous immune systems.

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Metadata

Authors
Aung, G., Niyonsaba, F., Ushio, H., Kajiwara, N., Saito, H., Ikeda, S., Ogawa, H., & Okumura, K.
Affiliations
  • Juntendo University (JP)
  • National Research Institute for Child Health and Development (JP)
Corresponding author
Niyonsaba, François
ORCID
Venue
Immunology
Publisher
Wiley
Published
2011-01-07
Volume
132
Issue
4
Pages
527-539
ISSN
0019-2805 (ISSN-L)
DOI
10.1111/j.1365-2567.2010.03395.x
PMC
PMC3075506
OpenAlex
W1511179279
Cited by
89
References
1
Citations by year
2026: 6 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 9 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 4
FWCI
2.26
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 1698 d)
Locations
  • Immunology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (21390303, 23390260)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Keywords
catestatin, mast cell activation, mast cell migration, mast cell degranulation, antimicrobial peptides, neuroendocrine peptides, skin inflammation, cytokine and chemokine production, calcium mobilization, G proteins, phospholipase C, ERK signaling, nicotinic acetylcholine receptors, LAD2 cells, single nucleotide polymorphisms, cutaneous immune system
MeSH terms
Amino Acid Sequence, Calcium, Cell Movement, Chemotaxis, Estrenes, Humans, Mast Cells, Molecular Sequence Data, Peptide Fragments, Phosphorylation, Pyrrolidinones, Receptors, Nicotinic, Blotting, Western, Prostaglandin D2, Dinoprostone, Cell Degranulation, Gene Expression, Cytokines, Leukotriene C4, Chemokines, Amino Acid Substitution, Reverse Transcriptase Polymerase Chain Reaction, Mitogen-Activated Protein Kinases, Antimicrobial Cationic Peptides, RNA Interference, Pertussis Toxin, Chromogranin A, alpha7 Nicotinic Acetylcholine Receptor

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