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Cited by 52Invertebrate Immune Response MechanismsEvolution and Genetic DynamicsAnimal Behavior and Reproduction

Host ecology shapes geographical variation for resistance to bacterial infection in Drosophila melanogaster

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Corby‐Harris, Vanessa, Promislow, Daniel E. L.·2008·Journal of Animal Ecology
DOI 10.1111/j.1365-2656.2008.01399.xPMC PMC3390212
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Abstract

1. Geographically distinct host populations often experience very different ecological conditions. These variable ecological conditions impact the strength of selection that these hosts experience from their parasites. 2. Numerous studies have characterized geographical patterns of resistance to infection among natural populations in the context of host-parasite local adaptation, but what other factors might contribute to these differences? 3. Here, we determined whether 20 naturally isolated populations of Drosophila melanogaster collected along the East Coast of the United States varied for survival after being inoculated with one of two species of bacteria--Lactococcus lactis and Pseudomonas aeruginosa. We then asked whether host environment accounted for the observed patterns of resistance. 4. Resistance to both types of infection varied spatially. The hosts' natural environment was predictive of the observed spatial variation in resistance to L. lactis, but not P. aeruginosa, infection. Specifically, hosts exposed to species-rich bacterial communities were more likely to survive the infection. 5. We conclude that biotic characteristics of the host environment, specifically the number of species of bacteria hosts encounter, shape host resistance to bacterial infection in nature. We discuss our results in the context of what is known about the evolutionary ecology of resistance in invertebrate systems.

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  • Examples of host immune specialisation cited by F&T may simply reflect hosts with generally better immune systems or host groups whose immune systems differ because of founder effects.

    “examples of host immune specialisation cited by F&T may simply reflect hosts with generally better immune systems (e.g., more major histocompatibility complexdiversity offering protection from a broad array of pathogens; Corby-Harris & Promislow 2008) or host groups whose immune systems differ because of founder effects (Miller et al. 2007).”

    From Parasite-stress promotes in-group assortative sociality: The cases of strong family ties and heightened religiosity (2012) · cites this paper as Corby-Harris & Promislow 2008

    The Discussion (page unavailable) reports that fly populations associated with species-rich bacterial communities were more resistant to a novel bacterial infection, supporting the general possibility of stronger host resistance. It discusses diversity in Dscam immune-gene variants as a possible mechanism, but does not address major histocompatibility complex diversity or demonstrate protection against a broad array of pathogens. The founder-effects clause is attributed to a different citation. (LLM, conf=0.85)

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Authors
Corby‐Harris, V., & Promislow, D. E. L.
Affiliations
University of Georgia (US)
Corresponding author
Corby‐Harris, Vanessa
ORCID
Venue
Journal of Animal Ecology
Publisher
Wiley
Published
2008-05-16
Volume
77
Issue
4
Pages
768-776
ISSN
  • 0021-8790 (ISSN-L)
  • 1365-2656
DOI
10.1111/j.1365-2656.2008.01399.x
PMC
PMC3390212
OpenAlex
W2155803078
Cited by
52
References
0
Citations by year
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FWCI
1.54
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Animal Ecology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation
  • Ellison Medical Foundation
  • National Oceanic and Atmospheric Administration
  • National Institute of General Medical Sciences (T32GM007103)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords
host-parasite interactions, bacterial infection resistance, Drosophila melanogaster, regional variation, host ecology, Lactococcus lactis, Pseudomonas aeruginosa, local adaptation, natural populations, evolutionary ecology
MeSH terms
Adaptation, Physiological, Animals, Drosophila melanogaster, Ecology, Geography, Immunity, Innate, Pseudomonas aeruginosa, Lactococcus lactis, Host-Pathogen Interactions

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