A comparison of the sterol content of multiple isolates of the Candida albicans Darlington strain with other clinically azole-sensitive and -resistant strains
Abstract
H owell , S.A., M allet , A.I. & N oble , W.C. 1990. A comparison of the sterol content of multiple isolates of the Candida albicans Darlington strain with other clinically azole‐sensitive and ‐resistant strains. Journal of Applied Bacteriology 69 , 692–696. The mechanism of azole resistance of Candida albicans NCPF 3310 (the deposited culture of the Darlington strain) has been investigated but never fully explained. Seven isolates of this strain, from various sources, were examined by gas chromatography‐mass spectrometry to detect changes in the sterol composition following passage through many laboratories over several years. Five of the seven, including one recently isolated from the patient, were found to be similar to each other in sterol content, containing large amounts of fecosterol. Of the remaining two, one was thought to be a sensitive variant, both produced only small quantities of fecosterol and resembled the normal clinical strains and other azole‐resistant strains in sterol content. The sterol composition of the Darlington strain was unique and apparently stable to prolonged in vitro experimentation and passage through the patient.
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Several mutant ERG3 clinical isolates have been identified and reportedly possess resistance to azole antifungals and cross-resistance to amphotericin B.
“several mutant ERG3 clinical isolates have been identified and reportedly possess resistance to the azole antifungals and cross-resistance to the polyene amphotericin B.”
From Molecular and genetic basis of azole antifungal resistance in the opportunistic pathogenic fungus<i>Candida albicans</i> (2020) · cites this paper as [144]
Cites
den Bossche, H. V., Willemsens, G., Cools, W., Lauwers, W., & Jeune, L. L. (1978) · Chemico-Biological Interactions · doi:10.1016/0009-2797(78)90068-6 · Cited by 281 · see citing works
ACQUIRED IMMUNE DEFICIENCY SYNDROME IN BLACK AFRICANS
Clumeck, N., Mascart-Lemone, F., Maubeuge, J. D., Brenez, D., & Marcelis, L. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91808-1 · Cited by 209 · see citing works
The Lipid Composition of Azole-sensitive and Azole-resistant Strains of Candida albicans
Hitchcock, C. A., Barrett-Bee, K. J., & Russell, N. J. (1986) · Microbiology · doi:10.1099/00221287-132-9-2421 · Cited by 98 · see citing works
Strain differentiation ofCandida albicansby morphotyping
Phongpaichit, S., Mackenzie, D. W. R., & Fraser, C. A. M. (1987) · Epidemiology and Infection · doi:10.1017/s0950268800067911 · Cited by 68 · see citing works
MODIFIED RESPONSE TO KETOCONAZOLE OF CANDIDA ALBICANS FROM A TREATMENT FAILURE
Warnock, D. W., Johnson, E. M., Richardson, M. D., & Vickers, C. F. H. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91809-3 · Cited by 57 · see citing works
Hitchcock, C. A., Barrett-Bee, K. J., & Russell, N. J. (1987) · Medical Mycology · doi:10.1080/02681218780000381 · Cited by 34 · see citing works
Ergosterol Biosynthesis in Yeast
Osumi, T., Taketani, S., Katsuki, H., et al. (1978) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a131961 · Cited by 33 · see citing works
Nuclear Demethylation and C-24 Alkylation During Ergosterol Biosynthesis in Saccharomyces cerevisiae
Fryberg, M., Avruch, L., Oehlschlager, A. C., et al. (1975) · Canadian Journal of Biochemistry · doi:10.1139/o75-120 · Cited by 19 · see citing works
Analysis of dihydroxyeicosatetraneoic acids by gas chromatography—mass spectrometry
Mallet, A. I., Barr, R., & Newton, J. A. (1986) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)80712-4 · Cited by 15 · see citing works
Self-citationHowell, S. A., Noble, W. C., Mallet, A. I., et al. (1989) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1290030707 · Cited by 2 · see citing works
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Sanglard, D., Kuchler, K., Ischer, F., Pagani, J. L., Monod, M., & Bille, J. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.11.2378 · Cited by 815 · see citing works
Geber, A., Hitchcock, C. A., Swartz, J. E., Pullen, F. S., Marsden, K. E., Kwon-Chung, K. J., & Bennett, J. E. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.12.2708 · Cited by 203 · see citing works
Mechanisms of Azole Resistance in Petite Mutants of <i>Candida glabrata</i>
Brun, S., Bergès, T., Poupard, P., Vauzelle-Moreau, C., Renier, G., Chabasse, D., & Bouchara, J.-P. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.5.1788-1796.2004 · Cited by 151 · see citing works
Nishimoto, A. T., Sharma, C., & Rogers, P. D. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz400 · Cited by 102 · see citing works
Miyazaki, Y., Geber, A., Miyazaki, H., Falconer, D., Parkinson, T., Hitchcock, C., Grimberg, B., Nyswaner, K., & Bennett, J. E. (1999) · Gene · doi:10.1016/s0378-1119(99)00263-2 · Cited by 71 · see citing works
Jia, X. M., Wang, Y., Jia, Y., Gao, P. H., Xu, Y. G., Wang, L., Cao, Y. Y., Cao, Y. B., Zhang, L. X., & Jiang, Y. Y. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8409-3 · Cited by 45 · see citing works
- Authors
- Howell, S. A., Mallet, A. I., & Noble, W. C.
- Affiliations
- St Thomas' Hospital (GB)
- ORCID
- Noble, W.C.
- Venue
- Journal of Applied Bacteriology
- Publisher
- Wiley
- Published
- 1990-11
- Volume
- 69
- Issue
- 5
- Pages
- 692-696
- ISSN
- 0021-8847 (ISSN-L)
- OpenAlex
- W2137242305
- Cited by
- 45
- References
- 10
- Citations by year
- 2021: 1 · 2019: 3 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Bacteriology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida albicans, azole resistance, sterol composition, clinical isolates, sterol biosynthesis
- MeSH terms
- Azoles, Candida albicans, Drug Resistance, Microbial, Ergosterol, Humans, Ketoconazole, Gas Chromatography-Mass Spectrometry, Sterols
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