The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Antifungal effects of herbal essential oils alone and in combination with ketoconazole against Trichophyton spp.
Abstract
AIMS: To determine the effects of herbal essential oils on Trichophyton spp. growth and to evaluate the effects of Pelargonium graveolens oil and its main components citronellol and geraniol combined with ketoconazole against Trichophyton spp. METHODS AND RESULTS: Growth inhibition of six Trichophyton spp. by herbal essential oils was accessed and the combined effects of P. graveolens oil and its main components citronellol and geraniol were evaluated using a checkerboard microtitre assay against T. schoenleinii, T. erinacei and T. soudanense. The essential oil fraction of P. graveolens and its main components, geraniol and citronellol, exhibited strong synergism with ketoconazole against T. schoenleinii and T. soudanense, with fractional inhibitory concentration (FIC) indices in the range of 0.18-0.38. CONCLUSIONS: The antifungal effects of ketoconazole against Trichophyton spp. are enhanced significantly by administering it in combination with the essential oil fraction of P. graveolens or its main components, because of strong synergism, especially against T. soudanense and T. schoenleinii. SIGNIFICANCE AND IMPACT OF THE STUDY: The combination of ketoconazole and the essential oil fraction from P. graveolens or its main components for treatment of infections caused by Trichophyton species may reduce the minimum effective dose of ketoconazole, and thus minimize the side-effects of ketoconazole.
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Cites
Antimicrobial activity of essential oils and other plant extracts
Hammer, K. A., Carson, C. F., & Riley, T. V. (1999) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.1999.00780.x · Cited by 2,560
Cited by
Synergism between natural products and antibiotics against infectious diseases
Hemaiswarya, S., Kruthiventi, A. K., & Doble, M. (2008) · Phytomedicine · doi:10.1016/j.phymed.2008.06.008 · Cited by 916
Ayaz, M., Ullah, F., Sadiq, A., Ullah, F., Ovais, M., Ahmed, J., & Devkota, H. P. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.05.050 · Cited by 359
Antibacterial effect of some essential oils administered alone or in combination with Norfloxacin
Rosato, A., Vitali, C., De Laurentis, N., Armenise, D., & Antonietta Milillo, M. (2007) · Phytomedicine · doi:10.1016/j.phymed.2007.01.005 · Cited by 287
Essential Oils as Potential Source of Anti‐Dandruff Agents: A Review
Arora, P., Nainwal, L. M., & Jain, S. (2022) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207324666210712094148 · Cited by 23
Metadata
- Authors
- Shin, S., & Lim, S.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-12
- Volume
- 97
- Issue
- 6
- Pages
- 1289-1296
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W2046141116
- Cited by
- 162
- References
- 1
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shin, S., & Lim, S. (2004). Antifungal effects of herbal essential oils alone and in combination with ketoconazole against Trichophyton spp. Journal of Applied Microbiology. https://doi.org/10.1111/j.1365-2672.2004.02417.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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