Role of epigenetics in pharmacotherapy, psychotherapy and nutritional management of mental disorders: Epigenetic management in mental disorders
Abstract
WHAT IS KNOWN AND OBJECTIVE: There is increasing evidence that epigenetics plays a major role in the pathogenesis of the idiopathic mental disorders. This article comments on the role of epigenetics in the pharmacotherapy, psychotherapy and nutritional management of these disorders. COMMENT: There are two classes of epigenetic drugs undergoing trials for treating the idiopathic mental disorders: DNA methyltransferase and histone deacetylase inhibitors. These drugs may fulfil the need for newer and more effective drugs for treating these disorders. Psychotherapy could exert its therapeutic effect in idiopathic mental disorders through epigenetic mechanisms. As nutrients like folic acid and vitamin B(12) can influence an individual's epigenome, especially early in life, abnormal intakes of such agents may be involved in the pathogenesis of the idiopathic mental disorders. Hence, adequate emphasis should be given to such factors in an individual's nutrition, especially early in life. Nutrients such as L-methylfolate and S-adenosylmethionine may also be useful in nutritional therapy of these disorders. WHAT IS NEW AND CONCLUSION: Epigenetics plays a key role in the pathogenesis of the idiopathic mental disorders. Due emphasis should be given to epigenetic mechanisms in the pharmacotherapy, psychotherapy and nutritional management of these disorders.
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Nutrition can influence the epigenetic machinery.
“Moreover, nutrition can influence the epigenetic machinery, and first studies have focused on the impact of haematopoietic drugs, folic acid and vitamin B12 (see Peedicayil, 2012).”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Peedicayil, 2012
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- Authors
- Peedicayil, J.
- Affiliations
- Christian Medical College, Vellore (IN)
- Corresponding author
- Peedicayil, J.
- ORCID
- Peedicayil, J.
- Venue
- Journal of Clinical Pharmacy and Therapeutics
- Publisher
- Hindawi Limited
- Published
- 2012-03-26
- Volume
- 37
- Issue
- 5
- Pages
- 499-501
- ISSN
- 0269-4727 (ISSN-L)
- OpenAlex
- W1653494058
- Cited by
- 32
- References
- 34
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2021: 4 · 2020: 1 · 2018: 4 · 2017: 2 · 2016: 3 · 2014: 6 · 2013: 4 · 2012: 2
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Pharmacy and Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- epigenetics, mental illness, hypomethylating agents, histone deacetylase inhibitors, psychotherapy, nutritional therapy, folic acid, vitamin B12, 5-methyltetrahydrofolate, S-adenosylmethionine, epigenetic drugs
- MeSH terms
- Mental Disorders, Food, Humans, Nutritional Status, Psychotherapy, DNA Methylation, Histone Deacetylase Inhibitors, Epigenomics
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