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The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients
Open accessAbstract
Abstract.: Objective. To determine the contribution of classical risk factors to the development of cardiovascular disease (CVD) in patients with heterozygous familial hypercholesterolaemia (FH). Design. A retrospective, multi‐centre, cohort study. Extensive data were collected by scrutinizing medical records and the use of questionnaires. Multivariate Cox regression was used to study the relationship between potential risk factors and the occurrence of CVD. Setting and subjects. We included 2400 FH patients from 27 Dutch lipid clinics. The diagnosis of FH was based upon the presence of a low‐density lipoprotein receptor mutation or upon strict clinical criteria. Main outcome measures. Cardiovascular mortality and CVD. Results. During 112.943 person‐years, 782 (32.6%) patients had had at least one cardiovascular event. Male gender (RR 2.82, 95% CI 2.37–3.36), smoking (RR 1.67, 95% CI 1.40–1.99), hypertension (RR 1.36, 95% CI 1.06–1.75), diabetes mellitus (RR 2.19, 95% CI 1.36–3.54), low HDL‐C (RR 1.37, 95% CI 1.15–1.63) and elevated lipoprotein(a) levels (RR 1.50, 95% CI 1.20–1.79) proved to be independent CVD risk factors. These six risk factors explained 18.7% of the variation in the occurrence of CVD. Conclusions. Male gender, smoking, hypertension, diabetes mellitus, HDL cholesterol and lipoprotein(a) levels proved to be important risk factors for CVD in FH patients. In addition to the routine instiQJ;tution of statin therapy, controlling these factors needs special attention in the management of this disorder.
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Cited by
Nordestgaard, B. G., Chapman, M. J., Humphries, S. E., Ginsberg, H. N., Masana, L., Descamps, O. S., Wiklund, O., Hegele, R. A., Raal, F. J., Defesche, J. C., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht273 · Cited by 2,761
Efficacy of statins in familial hypercholesterolaemia: a long term cohort study
Versmissen, J., Oosterveer, D. M., Yazdanpanah, M., Defesche, J. C., Basart, D. C. G., Liem, A. H., Heeringa, J., Witteman, J. C., Lansberg, P. J., Kastelein, J. J. P., et al. (2008) · BMJ · doi:10.1136/bmj.a2423 · Cited by 721
Self-citationKavey, R.-E. W., Allada, V., Daniels, S. R., Hayman, L. L., McCrindle, B. W., Newburger, J. W., Parekh, R. S., & Steinberger, J. (2006) · Circulation · doi:10.1161/circulationaha.106.179568 · Cited by 707
Familial Hypercholesterolemia: Screening, diagnosis and management of pediatric and adult patients
Goldberg, A. C., Hopkins, P. N., Toth, P. P., Ballantyne, C. M., Rader, D. J., Robinson, J. G., Daniels, S. R., Gidding, S. S., de Ferranti, S. D., Ito, M. K., et al. (2011) · Journal of clinical lipidology · doi:10.1016/j.jacl.2011.03.001 · Cited by 622
Mechanisms of disease: genetic causes of familial hypercholesterolemia
Soutar, A. K., & Naoumova, R. P. (2007) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0836 · Cited by 608
Metadata
- Authors
- Jansen, A. C. M., van Aalst‐Cohen, E. S., Tanck, M. W., Trip, M. D., Lansberg, P. J., Liem, A. H., Roeters van Lennep, H. W. O., Sijbrands, E. J. G., & Kastelein, J. J. P.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2004-11-19
- Volume
- 256
- Issue
- 6
- Pages
- 482-490
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2105612671
- Cited by
- 302
- References
- 0
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Jansen, A. C. M., van Aalst‐Cohen, E. S., Tanck, M. W., Trip, M. D., Lansberg, P. J., Liem, A. H., Roeters van Lennep, H. W. O., Sijbrands, E. J. G., & Kastelein, J. J. P. (2004). The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients. Journal of Internal Medicine. https://doi.org/10.1111/j.1365-2796.2004.01405.x
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