The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Impact of inflammation on epigenetic DNA methylation – a novel risk factor for cardiovascular disease?
Open accessAbstract
Abstract.: Objective. The lifespan of dialysis patients is as short as in patients with metastatic cancer disease, mainly due to cardiovascular disease (CVD). DNA methylation is an important cellular mechanism modulating gene expression associated with ageing, inflammation and atherosclerotic processes. Design. DNA methylation was analysed in peripheral blood leucocytes from three different groups of chronic kidney disease (CKD) populations (37 CKD stages 3 and 4 patients, 98 CKD stage 5 patients and 20 prevalent haemodialysis patients). Thirty‐six healthy subjects served as controls. Clinical characteristics (diabetes mellitus, nutritional status and presence of clinical CVD), inflammation and oxidative stress biomarkers, homocysteine and global DNA methylation in peripheral blood leucocytes (defined as Hpa II/Msp I ratio by the Luminometric Methylation Assay method) were evaluated. CKD stage 5 patients (n = 98) starting dialysis treatment were followed for a period of 36 ± 2 months. Results. Inflamed patients had lower ratios of Hpa II/Msp I, indicating global DNA hypermethylation. Analysis by the Cox regression model demonstrated that DNA hypermethylation (Hpa II/Msp I ratio <median) was significantly associated with both all‐cause (RR 5.0; 95% CI: 1.7–14.8; P < 0.01) and cardiovascular (RR 13.9; 95% CI: 1.8–109.3; P < 0.05) mortality, even following the adjustment for age, CVD, diabetes mellitus and inflammation. Conclusion. The present study demonstrates that global DNA hypermethylation is associated with inflammation and increased mortality in CKD.
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Cites
Clinical epidemiology of cardiovascular disease in chronic renal disease
Foley, R., Parfrey, P., & Sarnak, M. (1998) · American Journal of Kidney Diseases · doi:10.1053/ajkd.1998.v32.pm9820470 · Cited by 3,958
What is subjective global assessment of nutritional status?
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Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure
Stenvinkel, P., Heimbürger, O., Paultre, F., Diczfalusy, U., Wang, T., Berglund, L., & Jogestrand, T. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00422.x · Cited by 1,778
Self-citationInflammation enhances cardiovascular risk and mortality in hemodialysis patients
Zimmermann, J., Herrlinger, S., Pruy, A., Metzger, T., & Wanner, C. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00273.x · Cited by 1,531
Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients
Kalantar-Zadeh, K., Block, G., Humphreys, M. H., & Kopple, J. D. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00803.x · Cited by 1,247
The elephant in uremia: Oxidant stress as a unifying concept of cardiovascular disease in uremia
Himmelfarb, J., Stenvinkel, P., Ikizler, T. A., & Hakim, R. M. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00600.x · Cited by 1,179
Self-citationStenvinkel, P., Ketteler, M., Johnson, R. J., Lindholm, B., Pecoits-Filho, R., Riella, M., Heimbürger, O., Cederholm, T., & Girndt, M. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00200.x · Cited by 932
Self-citationRapid high-performance liquid chromatographic assay for total homocysteine levels in human serum
Ubbink, J. B., Hayward Vermaak, W. J., & Bissbort, S. (1991) · Journal of Chromatography B: Biomedical Sciences and Applications · doi:10.1016/0378-4347(91)80407-4 · Cited by 678
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C-Reactive Protein and the Risk of Incident Colorectal Cancer
Erlinger, T. P. (2004) · JAMA · doi:10.1001/jama.291.5.585 · Cited by 533
Cited by
Cardiovascular and noncardiovascular mortality among patients starting dialysis
de Jager, D. J. (2009) · JAMA · doi:10.1001/jama.2009.1488 · Cited by 755
Intra-individual Change Over Time in DNA Methylation With Familial Clustering
Bjornsson, H. T. (2008) · JAMA · doi:10.1001/jama.299.24.2877 · Cited by 702
Stenvinkel, P., Carrero, J. J. A. A., Axelsson, J., Lindholm, B., Heimbu[Combining Diaeresis]rger, O., & Massy, Z. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03670807 · Cited by 561
Self-citationFood as medicine: targeting the uraemic phenotype in chronic kidney disease
Mafra, D., Borges, N. A., Lindholm, B., Shiels, P. G., Evenepoel, P., & Stenvinkel, P. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00345-8 · Cited by 238
Self-citationSocio-economic status is associated with epigenetic differences in the pSoBid cohort
McGuinness, D., McGlynn, L. M., Johnson, P. C., MacIntyre, A., Batty, G. D., Burns, H., Cavanagh, J., Deans, K. A., Ford, I., McConnachie, A., et al. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr215 · Cited by 193
Metadata
- Authors
- Stenvinkel, P., Karimi, M., Johansson, S., Axelsson, J., Suliman, M., Lindholm, B., Heimbürger, O., Barany, P., Alvestrand, A., Nordfors, L., Qureshi, A. R., Ekström, T. J., & Schalling, M.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2007-01-30
- Volume
- 261
- Issue
- 5
- Pages
- 488-499
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2081219006
- Cited by
- 396
- References
- 28
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stenvinkel, P., Karimi, M., Johansson, S., Axelsson, J., Suliman, M., Lindholm, B., Heimbürger, O., Barany, P., Alvestrand, A., Nordfors, L., Qureshi, A. R., Ekström, T. J., & Schalling, M. (2007). Impact of inflammation on epigenetic DNA methylation – a novel risk factor for cardiovascular disease? Journal of Internal Medicine. https://doi.org/10.1111/j.1365-2796.2007.01777.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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