The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy: Symposium: The pulse of inflammation: implications for therapy
Open accessAbstract
Huston JM, Tracey KJ (Department of Surgery, Division of General Surgery, Trauma, Surgical Critical Care, and Burns, Stony Brook University Medical Center, Health Sciences Center, Stony Brook; and Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset; NY, USA). The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway, and implications for therapy (Key Symposium). J Intern Med 2011; 269: 45–53. Abstract. Biological therapeutics targeting TNF, IL-1 and IL-6 are widely used for treatment of rheumatoid arthritis, inflammatory bowel disease and a growing list of other syndromes, often with remarkable success. Now advances in neuroscience have collided with this therapeutic approach, perhaps rendering possible the development of nerve stimulators to inhibit cytokines. Action potentials transmitted in the vagus nerve culminate in the release of acetylcholine that blocks cytokine production by cells expressing acetylcholine receptors. The molecular mechanism of this cholinergic anti-inflammatory pathway is attributable to signal transduction by the nicotinic alpha 7 acetylcholine receptor subunit, a regulator of the intracellular signals that control cytokine transcription and translation. Favourable preclinical data support the possibility that nerve stimulators may be added to the future therapeutic armamentarium, possibly replacing some drugs to inhibit cytokines.
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Cites
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
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Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
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Self-citationNicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
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Self-citationCytokines sing the blues: inflammation and the pathogenesis of depression
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Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
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Self-citationde Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., van Westerloo, D. J., Bennink, R. J., Berthoud, H.-R., Uematsu, S., Akira, S., van den Wijngaard, R. M., et al. (2005) · Nature Immunology · doi:10.1038/ni1229 · Cited by 1,074
Huston, J. M., Ochani, M., Rosas-Ballina, M., Liao, H., Ochani, K., Pavlov, V. A., Gallowitsch-Puerta, M., Ashok, M., Czura, C. J., Foxwell, B., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052362 · Cited by 683
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Cited by
Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis
Chalmers, J. A., Quintana, D. S., Abbott, M. J.-A., & Kemp, A. H. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00080 · Cited by 1,067
The vagus nerve and the inflammatory reflex – linking immunity and metabolism
Pavlov, V. A., & Tracey, K. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.189 · Cited by 1,040
Self-citationVagal pathways for microbiome-brain-gut axis communication
Forsythe, P., Bienenstock, J., & Kunze, W. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_5 · Cited by 576
Kemp, A. H., & Quintana, D. S. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.06.018 · Cited by 538
Howland, R. H. (2014) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-014-0010-5 · Cited by 405
Metadata
- Authors
- Huston, J. M., & Tracey, K. J.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2010-12-16
- Volume
- 269
- Issue
- 1
- Pages
- 45-53
- ISSN
- 0954-6820 (ISSN-L)
- OpenAlex
- W1957047399
- Cited by
- 339
- References
- 20
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- green
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