The vagus nerve and the inflammatory reflex – linking immunity and metabolism
Open accessAbstract
The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory responses via the inflammatory reflex. Dysregulation of metabolism and immune function in obesity are associated with chronic inflammation, a critical step in the pathogenesis of insulin resistance and type 2 diabetes mellitus. Cholinergic mechanisms within the inflammatory reflex have, in the past 2 years, been implicated in attenuating obesity-related inflammation and metabolic complications. This knowledge has led to the exploration of novel therapeutic approaches in the treatment of obesity-related disorders.
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The inflammation-sensing and inflammation-suppressing functions outlined above provide the principal components of the inflammatory reflex.
“The inflammation-sensing and inflammation-suppressing functions outlined above provide the principal components of the inflammatory reflex (71).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [71]
The appearance of pathogenic organisms activates innate immune cells that release cytokines; these in turn activate sensory fibers that ascend in the vagus nerve to synapse in the nucleus tractus solitarius; increased efferent signals in the vagus nerve suppress peripheral cytokine release through macrophage nicotinic receptors and the CAIP.
“The appearance of pathogenic organisms activates innate immune cells that release cytokines. These in turn activate sensory fibers that ascend in the vagus nerve to synapse in the nucleus tractus solitarius. Increased efferent signals in the vagus nerve suppress peripheral cytokine release through macrophage nicotinic receptors and the CAIP.”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [71]
There are both speculative and well-established links between the autonomic and immune systems which could provide a mechanism for these results.
“there are both speculative (Pavlov and Tracey, 2012) and well-established (Felten, 1999) links between the autonomic and immune systems which could provide a mechanism for these results.”
From Effectiveness of a Novel Qigong Meditative Movement Practice for Impaired Health in Flight Attendants Exposed to Second-Hand Cigarette Smoke (2017) · cites this paper as Pavlov and Tracey, 2012
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Cites
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211 · see citing works
Self-citationInflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737 · see citing works
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728 · see citing works
Self-citationHotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works
European Guidelines for Obesity Management in Adults
Yumuk, V., Tsigos, C., Fried, M., Schindler, K., Busetto, L., Micic, D., & Toplak, H. (2015) · Obesity Facts · doi:10.1159/000442721 · Cited by 3,432 · see citing works
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., et al. (2003) · Nature · doi:10.1038/nature01339 · Cited by 3,228 · see citing works
Self-citationAdipocytokines: mediators linking adipose tissue, inflammation and immunity
Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,196 · see citing works
Sterile inflammation: sensing and reacting to damage
Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051 · see citing works
Macrophages, inflammation, and insulin resistance
Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733 · see citing works
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682 · see citing works
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works
Clinical application of C-reactive protein for cardiovascular disease detection and prevention
Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000053730.47739.3c · Cited by 2,513 · see citing works
Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503 · see citing works
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230 · see citing works
Human Fatty Liver Disease: Old Questions and New Insights
Cohen, J. C., Horton, J. D., & Hobbs, H. H. (2011) · Science · doi:10.1126/science.1204265 · Cited by 2,089 · see citing works
Recent advances in the relationship between obesity, inflammation, and insulin resistance.
Bastard, J., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., Capeau, J., & Fève, B. (2006) · PubMed · Cited by 2,069 · see citing works
NF-κB, Inflammation, and Metabolic Disease
Baker, R. G., Hayden, M. S., & Ghosh, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.008 · Cited by 1,952 · see citing works
Inflammation 2010: New Adventures of an Old Flame
Medzhitov, R. M. (2010) · Cell · doi:10.1016/j.cell.2010.03.006 · Cited by 1,854 · see citing works
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · see citing works
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works
Grundy, S. M. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.151092 · Cited by 1,571 · see citing works
Physiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563 · see citing works
Self-citationAcetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit
Rosas-Ballina, M., Olofsson, P. S., Ochani, M., Valdés-Ferrer, S. I., Levine, Y. A., Reardon, C., Tusche, M. W., Pavlov, V. A., Andersson, U., Chavan, S., et al. (2011) · Science · doi:10.1126/science.1209985 · Cited by 1,551 · see citing works
Self-citationInsulin and insulin resistance:
Sowers, J. R., & Frohlich, E. D. (2004) · Medical Clinics of North America · doi:10.1016/s0025-7125(03)00128-7 · Cited by 1,521 · see citing works
HMGB1 is a therapeutic target for sterile inflammation and infection
Andersson, U., & Tracey, K. J. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101323 · Cited by 1,437 · see citing works
Self-citationMasters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology · doi:10.1038/ni.1935 · Cited by 1,330 · see citing works
Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154 · see citing works
Self-citationSaper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120 · see citing works
de Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., van Westerloo, D. J., Bennink, R. J., Berthoud, H.-R., Uematsu, S., Akira, S., van den Wijngaard, R. M., et al. (2005) · Nature Immunology · doi:10.1038/ni1229 · Cited by 1,074 · see citing works
de La Serre, C. B., Ellis, C. L., Lee, J., Hartman, A. L., Rutledge, J. C., & Raybould, H. E. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2010 · Cited by 949 · see citing works
The weight of leptin in immunity
Cava, A. L., & Matarese, G. (2004) · Nature Reviews Immunology · doi:10.1038/nri1350 · Cited by 927 · see citing works
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904 · see citing works
The epidemiology of obesity: the size of the problem
James, W. P. T. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.01922.x · Cited by 785 · see citing works
Targeting gut microbiota in obesity: effects of prebiotics and probiotics
Delzenne, N. M., Neyrinck, A. M., Bäckhed, F., & Cani, P. D. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.126 · Cited by 783 · see citing works
Inflammatory mechanisms in the regulation of insulin resistance
Tilg, H., & Moschen, A. R. (2008) · Molecular Medicine · doi:10.2119/2007-00119.tilg · Cited by 779 · see citing works
Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776 · see citing works
The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
Pavlov, V. A., Wang, H., Czura, C. J., Friedman, S. G., & Tracey, K. J. (2003) · Molecular Medicine · doi:10.1007/bf03402177 · Cited by 772 · see citing works
Self-citationSplenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia
Rosas‐Ballina, M., Ochani, M., Parrish, W. R., Ochani, K., Harris, Y., Huston, J. M., Chavan, S. S., & Tracey, K. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803237105 · Cited by 757 · see citing works
Self-citationHypothalamic KATP channels control hepatic glucose production
Pocai, A., Lam, T. K. T., Gutierrez-Juarez, R., Obici, S., Schwartz, G. J., Bryan, J., Aguilar-Bryan, L., & Rossetti, L. (2005) · Nature · doi:10.1038/nature03439 · Cited by 645 · see citing works
The cholinergic anti-inflammatory pathway
Pavlov, V. A., & Tracey, K. J. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.03.015 · Cited by 622 · see citing works
Self-citationInteractions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes
Musso, G., Gambino, R., & Cassader, M. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-012510-175505 · Cited by 598 · see citing works
Vagal immune-to-brain communication: a visceral chemosensory pathway
Goehler, L. E., Gaykema, R. P. A., Hansen, M. K., Anderson, K., Maier, S. F., & Watkins, L. R. (2000) · Autonomic Neuroscience · doi:10.1016/s1566-0702(00)00219-8 · Cited by 525 · see citing works
Ghanim, H., Abuaysheh, S., Sia, C. L., Korzeniewski, K., Chaudhuri, A., Fernandez-Real, J. M., & Dandona, P. (2009) · Diabetes Care · doi:10.2337/dc09-0979 · Cited by 494 · see citing works
(U.S.), N. L. O. M. (2008) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/15360280801989377 · Cited by 474 · see citing works
Nicotine Decreases Food Intake Through Activation of POMC Neurons
Mineur, Y. S., Abizaid, A., Rao, Y., Salas, R., DiLeone, R. J., Gündisch, D., Diano, S., De Biasi, M., Horvath, T. L., Gao, X.-B., et al. (2011) · Science · doi:10.1126/science.1201889 · Cited by 439 · see citing works
Pavlov, V. A., Parrish, W. R., Rosas‐Ballina, M., Ochani, M., Gallowitsch‐Puerta, M., Ochani, K., Chavan, S. S., Al‐Abed, Y., & Tracey, K. J. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.06.011 · Cited by 437 · see citing works
Self-citationHypothalamic sensing of circulating fatty acids is required for glucose homeostasis
Lam, T. K. T., Pocai, A., Gutierrez-Juarez, R., Obici, S., Bryan, J., Aguilar-Bryan, L., Schwartz, G. J., & Rossetti, L. (2005) · Nature Medicine · doi:10.1038/nm1201 · Cited by 432 · see citing works
Reflex principles of immunological homeostasis
Andersson, U., & Tracey, K. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075015 · Cited by 414 · see citing works
Self-citationGhia, J., Blennerhassett, P. A., Kumar–Ondiveeran, H., Verdu, E. F., & Collins, S. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.016 · Cited by 404 · see citing works
Cognitive function, dementia and type 2 diabetes mellitus in the elderly
Strachan, M. W. J., Reynolds, R. M., Marioni, R. E., & Price, J. F. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.228 · Cited by 402 · see citing works
Heart rate variability in obesity and the effect of weight loss
Karason, K., Mølgaard, H., Wikstrand, J., & Sjöström, L. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00066-1 · Cited by 402 · see citing works
A brain-liver circuit regulates glucose homeostasis
Pocai, A., Obici, S., Schwartz, G. J., & Rossetti, L. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.001 · Cited by 392 · see citing works
Attenuation of leptin and insulin signaling by SOCS proteins
Howard, J. K., & Flier, J. S. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.09.007 · Cited by 371 · see citing works
Ek, M., Kurosawa, M., Lundeberg, T., & Ericsson, A. B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09471.1998 · Cited by 370 · see citing works
Kreier, F., Fliers, E., Voshol, P. J., van Eden, C. G., Havekes, L. M., Kalsbeek, A., Heijningen, C. L. V., Sluiter, A. A., Mettenleiter, T. C., Romijn, J. A., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15736 · Cited by 363 · see citing works
Goehler, L. E., Gaykema, R. P. A., Nguyen, K. T., Lee, J. E., Tilders, F. J. H., Maier, S. F., & Watkins, L. R. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02799.1999 · Cited by 357 · see citing works
Pavlov, V. A., Ochani, M., Yang, L., Gallowitsch‐Puerta, M., Ochani, K., Lin, X., Levi, J., Parrish, W. R., Rosas‐Ballina, M., Czura, C. J., et al. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000259381.56526.96 · Cited by 353 · see citing works
Self-citationHuston, J. M., & Tracey, K. J. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02321.x · Cited by 342 · see citing works
Self-citationCentral muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia
Pavlov, V. A., Ochani, M., Gallowitsch-Puerta, M., Ochani, K., Huston, J. M., Czura, C. J., Al-Abed, Y., & Tracey, K. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600506103 · Cited by 336 · see citing works
Self-citationKreier, F., Fliers, E., Voshol, P. J., van Eden, C. G., Havekes, L. M., Kalsbeek, A., Heijningen, C. L. V., Sluiter, A. A., Mettenleiter, T. C., Romijn, J. A., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215736 · Cited by 331 · see citing works
Parrish, W. R., Rosas‐Ballina, M., Gallowitsch‐Puerta, M., Ochani, M., Ochani, K., Yang, L., Hudson, L., Lin, X., Patel, N. B., Johnson, S. M., et al. (2008) · Molecular Medicine · doi:10.2119/2008-00079.parrish · Cited by 328 · see citing works
Self-citationGuarini, S., Altavilla, D., Cainazzo, M.-M., Giuliani, D., Bigiani, A., Marini, H., Squadrito, G., Minutoli, L., Bertolini, A., Marini, R., et al. (2003) · Circulation · doi:10.1161/01.cir.0000050627.90734.ed · Cited by 315 · see citing works
Rodriguez‐Diaz, R., Dando, R., Jacques-Silva, M. C., Fachado, A., Molina, J., Abdulreda, M. H., Ricordi, C., Roper, S. D., Berggren, P., & Caicedo, A. (2011) · Nature Medicine · doi:10.1038/nm.2371 · Cited by 305 · see citing works
Long Term Vagal Stimulation in Patients with Advanced Heart Failure First Experience in Man
Schwartz, P. J., Ferrari, G. M. D., Sanzo, A., Landolina, M., Rordorf, R., Raineri, C., Campana, C., Revera, M., Ajmone-Marsan, N., Tavazzi, L., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.07.016 · Cited by 302 · see citing works
Gautam, D., Han, S.-J., Hamdan, F. F., Jeon, J., Li, B., Li, J. H., Cui, Y., Mears, D., Lu, H., Deng, C., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.009 · Cited by 299 · see citing works
Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve
Luyer, M. D., Greve, J. W. M., Hadfoune, M., Jacobs, J. A., Dejong, C. H., & Buurman, W. A. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042397 · Cited by 295 · see citing works
Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production
Wang, P. Y. T., Caspi, L., Lam, C., Chari, M., Li, X., Light, P. E., Juárez, R. G., Ang, M. L. T., Schwartz, G. J., & Lam, T. K. T. (2008) · Nature · doi:10.1038/nature06852 · Cited by 293 · see citing works
Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation
Laugerette, F., Vors, C., Géloën, A., Chauvin, M., Soulage, C. O., Lambert-Porcheron, S., Peretti, N., Alligier, M., Burcelin, R., Laville, M., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.11.011 · Cited by 291 · see citing works
Leinonen, E. S., Hurt‐Camejo, E., Wiklund, O., Hultén, L. M., Hiukka, A., & Taskinen, M. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(02)00371-4 · Cited by 275 · see citing works
Brain Insulin Controls Adipose Tissue Lipolysis and Lipogenesis
Scherer, T., O’Hare, J., Diggs‐Andrews, K. A., Schweiger, M., Cheng, B., Lindtner, C., Zieliński, E., Vempati, P., Su, K., Dighe, S. V., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.008 · Cited by 262 · see citing works
Niijima, A. (1996) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(96)00098-7 · Cited by 261 · see citing works
Leptin modulates β cell expression of IL-1 receptor antagonist and release of IL-1β in human islets
Maedler, K., Sergeev, P., Ehses, J. A., Máthé, Z., Bosco, D., Berney, T., Dayer, J., Reinecke, M., Halban, P. A., & Donath, M. Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305683101 · Cited by 248 · see citing works
The Metabolic Syndrome and Inflammation
Sutherland, J. P., McKinley, B., & Eckel, R. H. (2004) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2004.2.82 · Cited by 243 · see citing works
KITAGAWA, H., TAKENOUCHI, T., Azuma, R., Wesnes, K. A., Kramer, W. G., Clody, D. E., & Burnett, A. L. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300028 · Cited by 238 · see citing works
The role of the autonomic nervous liver innervation in the control of energy metabolism
Yi, C., la Fleur, S. E., Fliers, E., & Kalsbeek, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.01.006 · Cited by 229 · see citing works
The Role of Cytokines in Non-Alcoholic Fatty Liver Disease
Tilg, H. (2010) · Digestive Diseases · doi:10.1159/000282083 · Cited by 227 · see citing works
Novel pathway for LPS-induced afferent vagus nerve activation: Possible role of nodose ganglion
Hosoi, T., Okuma, Y., Matsuda, T., & Nomura, Y. (2005) · Autonomic Neuroscience · doi:10.1016/j.autneu.2004.11.012 · Cited by 223 · see citing works
Controlling inflammation: the cholinergic anti-inflammatory pathway
Pavlov, V. A., & Tracey, K. J. (2006) · Biochemical Society Transactions · doi:10.1042/bst0341037 · Cited by 221 · see citing works
Self-citationVagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1
Nakabayashi, H., NISHIZAWA, M., Nakagawa, A., Takeda, R., & Niijima, A. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.5.e808 · Cited by 203 · see citing works
Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms
Balkan, B., & Li, X. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1449 · Cited by 201 · see citing works
Hypothalamic Responses to Long-chain Fatty Acids Are Nutritionally Regulated
Morgan, K., Obici, S., & Rossetti, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400458200 · Cited by 187 · see citing works
Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons
de Lartigue, G., Barbier de la Serre, C., Espero, E., Lee, J., & Raybould, H. E. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00056.2011 · Cited by 179 · see citing works
Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network
Cheung, G. W. C., Kokorovic, A., Lam, C., Chari, M., & Lam, T. K. T. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.07.005 · Cited by 179 · see citing works
Giordano, A., Song, C. K., Bowers, R. R., Ehlen, J. C., Frontini, A., Cinti, S., & Bartness, T. J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00679.2005 · Cited by 177 · see citing works
Neural regulators of innate immune responses and inflammation
Pavlov, V. A., & Tracey, K. J. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4102-3 · Cited by 174 · see citing works
Self-citationNeuro-immune interactions via the cholinergic anti-inflammatory pathway
Gallowitsch‐Puerta, M., & Pavlov, V. A. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.01.002 · Cited by 172 · see citing works
Self-citationInfluence of Autonomic Nervous System Dysfunction on the Development of Type 2 Diabetes
Carnethon, M. R., Jacobs, D. R., Sidney, S. S., & Liu, K. (2003) · Diabetes Care · doi:10.2337/diacare.26.11.3035 · Cited by 171 · see citing works
The contribution of the vagus nerve in interleukin-1β-induced fever is dependent on dose
Hansen, M. K., O'Connor, K. A., Goehler, L. E., Watkins, L. R., & Maier, S. F. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.4.r929 · Cited by 169 · see citing works
Olofsson, P. S., Katz, D. A., Rosas‐Ballina, M., Levine, Y. A., Ochani, M., Valdés‐Ferrer, S. I., Pavlov, V. A., Tracey, K. J., & Chavan, S. S. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00405 · Cited by 163 · see citing works
Self-citationKoopman, F. A., Stoof, S. P., Straub, R. H., van Maanen, M. A., Vervoordeldonk, M. J., & Tak, P. P. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00065 · Cited by 155 · see citing works
Sensors of the innate immune system: their mode of action
Baccalà, R., González‐Quintial, R., Lawson, B. R., Stern, M. E., Kono, D. H., Beutler, B., & Theofilopoulos, A. N. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.136 · Cited by 145 · see citing works
Pardo, J. V., Sheikh, S. A., Kuskowski, M. A., Surerus-Johnson, C., Hagen, M. C., Lee, J. T., Rittberg, B. R., & Adson, D. E. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803666 · Cited by 142 · see citing works
The cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis
van Maanen, M. A., Vervoordeldonk, M. J., & Tak, P. P. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.31 · Cited by 140 · see citing works
GUARINI, S. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.03.029 · Cited by 131 · see citing works
Wang, X., Yang, Z., Xue, B., & Shi, H. (2011) · Endocrinology · doi:10.1210/en.2010-0855 · Cited by 126 · see citing works
Val‐Laillet, D., Biraben, A., Randuineau, G., & Malbert, C. (2010) · Appetite · doi:10.1016/j.appet.2010.06.008 · Cited by 124 · see citing works
Behavioral and pharmacologic therapies for obesity
Vetter, M. L., Faulconbridge, L. F., Webb, V. L., & Wadden, T. A. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.121 · Cited by 124 · see citing works
Satapathy, S. K., Ochani, M., Dancho, M. E., Hudson, L., Rosas‐Ballina, M., Valdés‐Ferrer, S. I., Olofsson, P. S., Harris, Y., Roth, J., Chavan, S. S., et al. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00083 · Cited by 119 · see citing works
Self-citationEpidemic Inflammation: Pondering Obesity
Nathan, C. (2008) · Molecular Medicine · doi:10.2119/2008-00038.nathan · Cited by 118 · see citing works
Therapeutic Approaches to Target Inflammation in Type 2 Diabetes
Goldfine, A. B., Fonseca, V. A., & Shoelson, S. E. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2010.148833 · Cited by 116 · see citing works
A high-fat meal is accompanied by increased plasma interleukin-6 concentrations
Lundman, P., Boquist, S., Samnegård, A., Bennermo, M. B., Held, C., Ericsson, C.-G., Silveira, A. M. V., Hamsten, A., & Tornvall, P. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.11.009 · Cited by 108 · see citing works
Hamano, R., Takahashi, H. K., Iwagaki, H., Yoshino, T., Nishibori, M., & Tanaka, N. (2006) · Shock · doi:10.1097/01.shk.0000228168.86845.60 · Cited by 108 · see citing works
Marrero, M. B., Lucas, R., Salet, C., Hauser, T. A., Mazurov, A. A., Lippiello, P. M., & Bencherif, M. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.154633 · Cited by 105 · see citing works
Weston–Green, K., Huang, X., Lian, J., & Deng, C. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.09.003 · Cited by 97 · see citing works
The Expression and Functional Role of Nicotinic Acetylcholine Receptors in Rat Adipocytes
Liu, R., Mizuta, M., & Matsukura, S. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.065037 · Cited by 96 · see citing works
Vagal control of satiety and hormonal regulation of appetite
Owyang, C., & Heldsinger, A. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.4.338 · Cited by 87 · see citing works
Bueter, M., Löwenstein, C., Ashrafian, H., Hillebrand, J. J., Bloom, S. R., Olbers, T., Lutz, T. A., & le Roux, C. W. (2010) · Obesity Surgery · doi:10.1007/s11695-010-0075-5 · Cited by 84 · see citing works
Lee, J., Cummings, B. P., Martin, E. M., Sharp, J. W., Graham, J. L., Stanhope, K. L., Havel, P. J., & Raybould, H. E. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00345.2011 · Cited by 84 · see citing works
Lam, C., Chari, M., Su, B., Cheung, G. W. C., Kokorovic, A., Yang, C. S., Wang, P. Y. T., Lai, T. Y. Y., & Lam, T. K. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.087338 · Cited by 83 · see citing works
Cholinergic Stimulation of the Rat Hypothalamus: Effects of Liver Glycogen Synthesis
Shimazu, T., Matsushita, H., & Ishikawa, K. (1976) · Science · doi:10.1126/science.9692 · Cited by 79 · see citing works
Ziegler, D., Zentai, C. P., Perz, S., Rathmann, W., Haastert, B., Meisinger, C., & Löwel, H. (2006) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2006-924083 · Cited by 76 · see citing works
Modulation of Nicotinic Receptor Activity in the Central Nervous System
Albuquerque, E. X., Santos, M. D., Alkondon, M., Pereira, E. F. R., & Maelicke, A. (2001) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200108001-00004 · Cited by 72 · see citing works
Kampe, J., Tschöp, M. H., Hollis, J. H., & Oldfield, B. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06818.x · Cited by 69 · see citing works
Ribeiz, S. R. I., Bassitt, D. P., Arrais, J., Ávila, R., Steffens, D. C., & Bottino, C. M. C. (2010) · CNS Drugs · doi:10.2165/11530260-000000000-00000 · Cited by 68 · see citing works
Ribeiro, R. T., Lautt, W. W., Légaré, D. J., & Macedo, M. P. (2005) · Diabetologia · doi:10.1007/s00125-005-1714-6 · Cited by 68 · see citing works
Eckel, R. H. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005320 · Cited by 68 · see citing works
Cholinergic anti-inflammatory pathway in intracerebral hemorrhage
Lee, S., Chu, K., Jung, K., Kang, K.-M., Kim, J. H., Bahn, J.-J., Jeon, D., Kim, M., Lee, S. K., & Roh, J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.10.076 · Cited by 67 · see citing works
Atypical antipsychotics and the neural regulation of food intake and peripheral metabolism
Teff, K. L., & Kim, S. F. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.05.033 · Cited by 67 · see citing works
Role of the Cholinergic Antiinflammatory Pathway in Murine Autoimmune Myocarditis
Leib, C., Göser, S., Lüthje, D., Öttl, R., Tretter, T., Lasitschka, F., Zittrich, S., Pfitzer, G., Katus, H. A., & Kaya, Z. (2011) · Circulation Research · doi:10.1161/circresaha.111.245563 · Cited by 66 · see citing works
Bugajski, A. J., Gil, K., Ziomber, A., Zurowski, D., Zaraska, W., & Thor, P. (2007) · PubMed · Cited by 65 · see citing works
Cancello, R., Zulian, A., Maestrini, S., Mencarelli, M., Barba, A. D., Invitti, C., Liuzzi, A., & Blasio, A. M. D. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.275 · Cited by 62 · see citing works
Cholinergic modulation of inflammation.
Pavlov, V. A. (2008) · PubMed Central · Cited by 59 · see citing works
Self-citationde Azúa, I. R., Gautam, D., Guettier, J., & Wess, J. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.10.004 · Cited by 56 · see citing works
Handa, T., Katare, R., Kakinuma, Y., Arikawa, M., Ando, M., Sasaguri, S., Yamasaki, F., & Sato, T. (2009) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2009.05.008 · Cited by 54 · see citing works
Olanzapine-induced accumulation of adipose tissue is associated with an inflammatory state
Victoriano, M., de Beaurepaire, R., Naour, N., Guerre-Millo, M., Quignard‐Boulangé, A., Huneau, J., Mathé, V., Tomé, D., & Hermier, D. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.060 · Cited by 54 · see citing works
Impaired Vagal Reflex Activity in Insulin-Resistant Rats
Miller, A. W., Sims, J., Canavan, A., Hsu, T., & Ujhelyi, M. R. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199905000-00004 · Cited by 51 · see citing works
Cholinergic Modulation of Appetite-Related Synapses in Mouse Lateral Hypothalamic Slice
Jo, Y., Wiedl, D., & Role, L. W. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3638-05.2005 · Cited by 48 · see citing works
Clancy, J. A., Deuchars, S. A., & Deuchars, J. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.064543 · Cited by 44 · see citing works
Intestinal glucose-induced calcium-calmodulin kinase signaling in the gut-brain axis in awake rats
Vincent, K. M., Sharp, J. W., & Raybould, H. E. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01673.x · Cited by 43 · see citing works
Interleukin-1β sensitizes the response of the gastric vagal afferent to cholecystokinin in rat
Bucinskaite, V., Kurosawa, M., Miyasaka, K., Funakoshi, A., & Lundeberg, T. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00406-0 · Cited by 43 · see citing works
Spinal p38 MAP kinase regulates peripheral cholinergic outflow
Waldburger, J., Boyle, D. L., Edgar, M. M., Sorkin, L. S., Levine, Y. A., Pavlov, V. A., Tracey, K. J., & Firestein, G. S. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23807 · Cited by 42 · see citing works
Self-citationThe Cholinergic Anti-Inflammatory Pathway and the Gastrointestinal Tract
Bonaz, B. L. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.061 · Cited by 40 · see citing works
Impact of Surgically Induced Weight Loss on Cardiovascular Autonomic Function: One‐year Follow‐up
Maser, R. E., Lenhard, M. J., Irgau, I., & Wynn, G. M. (2007) · Obesity · doi:10.1038/oby.2007.554 · Cited by 40 · see citing works
Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoprotein E-knockout mice
Inanaga, K., Ichiki, T., Miyazaki, R., Takeda, K., Hashimoto, T., Matsuura, H., & Sunagawa, K. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.07.027 · Cited by 33 · see citing works
Effects of interactions between interleukin‐1β and leptin on cat intestinal vagal mechanoreceptors
Gaigé, S., Abou, E., Abysique, A., & Bouvier, M. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.054379 · Cited by 25 · see citing works
Matsushita, H., Ishikawa, K., & Shimazu, T. (1979) · Brain Research · doi:10.1016/0006-8993(79)90353-6 · Cited by 23 · see citing works
Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes
Citrome, L., & Volavka, J. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0818c · Cited by 20 · see citing works
Cardiac autonomic nerve function and insulin sensitivity in obese subjects.
Wo, R., Geiss, H., Aleksić, S., & SCHWANDT, P. (1996) · PubMed · Cited by 18 · see citing works
The Effects of Vagotomy on Bacterial Translocation: An Experimental Study
Doḡ, M., Kama, N. A., Yazgan, A., Aksoy, M., Ergul, G., & Tekelı, A. (1997) · Journal of Surgical Research · doi:10.1006/jsre.1997.5157 · Cited by 10 · see citing works
濱野, 亮. (2007) · Institutional Repositories DataBase (IRDB) · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 148 references couldn’t be matched to a known paper.
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Sorted by citations
Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders
Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00044 · Cited by 1,189 · see citing works
Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis
Chalmers, J. A., Quintana, D. S., Abbott, M. J.-A., & Kemp, A. H. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00080 · Cited by 1,067 · see citing works
“The mechanism underpinning the relationship between mental and physical health may, in part, relate to impairment in vagal nerve activity leading to a dysregulation of inflammatory processes (11, 12).”
BackgroundDiabetes Mellitus and Inflammation
Lontchi‐Yimagou, E., Sobngwi, E., Matsha, T. E., & Kengne, A. P. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0375-y · Cited by 814 · see citing works
Mechanisms and Therapeutic Relevance of Neuro-immune Communication
Chavan, S. S., Pavlov, V. A., & Tracey, K. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.008 · Cited by 661 · see citing works
Self-citationResolution of Inflammation: What Controls Its Onset?
Sugimoto, M. A., Sousa, L. P., Pinho, V., Perretti, M., & Teixeira, M. M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00160 · Cited by 638 · see citing works
Wireless Recording in the Peripheral Nervous System with Ultrasonic Neural Dust
Seo, D., Neely, R. M., Shen, K., Singhal, U., Alon, E., Rabaey, J. M., Carmena, J. M., & Maharbiz, M. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.034 · Cited by 557 · see citing works
Kemp, A. H., & Quintana, D. S. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.06.018 · Cited by 538 · see citing works
Neural regulation of immunity: molecular mechanisms and clinical translation
Pavlov, V. A., & Tracey, K. J. (2017) · Nature Neuroscience · doi:10.1038/nn.4477 · Cited by 534 · see citing works
Self-citationSlavich, G. M. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045159 · Cited by 502 · see citing works
“These regions in turn project to the brainstem nuclei, hypothalamus, and forebrain,which integrate visceral sensory information and coordinate autonomic and behavioral responses (Pavlov & Tracey 2012).”
BackgroundHeart Rate Variability in Psychology: A Review of HRV Indices and an Analysis Tutorial
Pham, T., Lau, Z. J., Chen, S. A., & Makowski, D. (2021) · Sensors · doi:10.3390/s21123998 · Cited by 486 · see citing works
Molecular and functional neuroscience in immunity
Pavlov, V. A., Chavan, S. S., & Tracey, K. J. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053158 · Cited by 444 · see citing works
Self-citationAn Atlas of Vagal Sensory Neurons and Their Molecular Specialization
Kupari, J., Häring, M., Agirre, E., Castelo‐Branco, G., & Ernfors, P. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.096 · Cited by 445 · see citing works
Association of Stress-Related Disorders With Subsequent Autoimmune Disease
Song, H., Fang, F., Tómasson, G., Arnberg, F. K., Mataix‐Cols, D., de la Cruz, L. F., Almqvist, C., Fall, K., & Valdimarsdóttir, U. A. (2018) · JAMA · doi:10.1001/jama.2018.7028 · Cited by 438 · see citing works
The resolution of inflammation: Principles and challenges
Headland, S. E., & Norling, L. V. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.014 · Cited by 415 · see citing works
Macrophage Activation and Polarization as an Adaptive Component of Innate Immunity
Locati, M., Mantovani, A., & Sica, A. (2013) · Advances in immunology · doi:10.1016/b978-0-12-417028-5.00006-5 · Cited by 405 · see citing works
Howland, R. H. (2014) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-014-0010-5 · Cited by 405 · see citing works
Zhu, X., Chen, Z., Shen, W., Huang, G., Sedivy, J. M., Wang, H., & Ju, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00646-9 · Cited by 410 · see citing works
Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity
Colonna, M. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.013 · Cited by 397 · see citing works
Brain–gut–microbiota axis in depression: A historical overview and future directions
Chang, L., Wei, Y., & Hashimoto, K. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.004 · Cited by 382 · see citing works
Vagus Nerve and Vagus Nerve Stimulation, a Comprehensive Review: Part III
Yuan, H., & Silberstein, S. D. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12649 · Cited by 381 · see citing works
Chronic kidney disease and premature ageing
Kooman, J. P., Kotanko, P., Schols, A. M. W. J., Shiels, P. G., & Stenvinkel, P. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.185 · Cited by 383 · see citing works
Heart rate variability and inflammation: A meta-analysis of human studies
Williams, D. P., Koenig, J., Carnevali, L., Sgoifo, A., Jarczok, M. N., STERNBERG, E. M., & Thayer, J. F. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.03.009 · Cited by 366 · see citing works
Farmer, A. D., Strzelczyk, A., Finisguerra, A., Gourine, A. V., Gharabaghi, A., Hasan, A., Burger, A. M., Jaramillo, A. M., Mertens, A., Majid, A., et al. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.568051 · Cited by 361 · see citing works
Silva, N. M. L. E., Gonçalves, R. A., Pascoal, T. A., Lima‐Filho, R. A. S., Resende, E. D. P. F., Vieira, É. L. M., Teixeira, A. L., de Souza, L. C., Peny, J. A., Fortuna, J. T. S., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01349-z · Cited by 352 · see citing works
Effective weight control via an implanted self-powered vagus nerve stimulation device
Yao, G., Kang, L., Li, J., Long, Y., Wei, H., Ferreira, C. A., Jeffery, J. J., Lin, Y., Cai, W., & Wang, X. (2018) · Nature Communications · doi:10.1038/s41467-018-07764-z · Cited by 348 · see citing works
Vagal neurocircuitry and its influence on gastric motility
Travagli, R. A., & Anselmi, L. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.76 · Cited by 323 · see citing works
The gut microbiota-immune-brain axis: therapeutic implications
O’Riordan, K. J., Moloney, G. M., Keane, L., Clarke, G., & Cryan, J. F. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101982 · Cited by 333 · see citing works
Current Directions in the Auricular Vagus Nerve Stimulation I – A Physiological Perspective
Kaniušas, E., Kampusch, S., Tittgemeyer, M., Panetsos, F., Gines, R. F., Papa, M., Kiss, A., Podesser, B. K., Cassara, A. M., Tanghe, E., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00854 · Cited by 331 · see citing works
A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications
Changeux, J., Amoura, Z., Rey, F. A., & Miyara, M. (2020) · Comptes Rendus Biologies · doi:10.5802/crbiol.8 · Cited by 302 · see citing works
Koenig, J., Kemp, A. H., Beauchaine, T. P., Thayer, J. F., & Kaess, M. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.04.013 · Cited by 285 · see citing works
Salliss, M. E., Farland, L. V., Mahnert, N. D., & Herbst‐Kralovetz, M. M. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab035 · Cited by 287 · see citing works
Neural Regulation of Hematopoiesis, Inflammation, and Cancer
Hanoun, M., Maryanovich, M., Arnal-Estapé, A., & Frenette, P. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.026 · Cited by 265 · see citing works
Young, H. A., & Benton, D. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000383 · Cited by 249 · see citing works
Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors
Zoli, M., Pucci, S., Vilella, A., & Gotti, C. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170912110450 · Cited by 260 · see citing works
Pavlov, V. A., & Tracey, K. J. (2015) · Immunologic Research · doi:10.1007/s12026-015-8718-1 · Cited by 254 · see citing works
Self-citationFatigue, Sleep, and Autoimmune and Related Disorders
Zielinski, M. R., Systrom, D. M., & Rose, N. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01827 · Cited by 266 · see citing works
Neuroinflammation, Sleep, and Circadian Rhythms
Zielinski, M. R., & Gibbons, A. J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.853096 · Cited by 260 · see citing works
Liu, R. T., Rowan-Nash, A. D., Sheehan, A. E., Walsh, R. F. L., Sanzari, C. M., Korry, B. J., & Belenky, P. A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.03.026 · Cited by 244 · see citing works
Inflammatory pathways of seizure disorders
Marchi, N., Granata, T., & Janigro, D. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.11.002 · Cited by 241 · see citing works
Regulation of energy balance by a gut–brain axis and involvement of the gut microbiota
Bauer, P. V., Hamr, S. C., & Duca, F. A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2083-z · Cited by 217 · see citing works
Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation
Cotero, V. E., Fan, Y., Tsaava, T., Kressel, A. M., Hancu, I., Fitzgerald, P. B., Wallace, K. D., Kaanumalle, S., Graf, J. F., Rigby, W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08750-9 · Cited by 217 · see citing works
Self-citationVagal nerve stimulation for treatment-resistant depression
Carreno, F. R., & Frazer, A. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0537-8 · Cited by 208 · see citing works
Central cholinergic activation of a vagus nerve - to spleen circuit alleviates experimental colitis
Ji, H., Rabbi, M. F., Labis, B., Pavlov, V. A., Tracey, K., & Ghia, J. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.52 · Cited by 197 · see citing works
Self-citationIdentification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity
Zanos, T. P., Silverman, H. A., Levy, T. J., Tsaava, T., Battinelli, E., Lorraine, P. W., Ashe, J. M., Chavan, S. S., Tracey, K. J., & Bouton, C. E. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719083115 · Cited by 196 · see citing works
Self-citationThe crosstalk between autonomic nervous system and blood vessels.
Sheng, Y., & Zhu, L. (2018) · PubMed Central · Cited by 196 · see citing works
de Melo, Nunes, S. O. V., Anderson, G., Vargas, H. O., Barbosa, D. S., Gałecki, P., Carvalho, A. F., & Maes, M. H. J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.027 · Cited by 189 · see citing works
Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity
Halder, N., & Lal, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660342 · Cited by 186 · see citing works
Peripheral and central mechanisms of stress resilience
Pfau, M. L., & Russo, S. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.004 · Cited by 170 · see citing works
Learning and memory … and the immune system
Marin, I., & Kipnis, J. (2013) · Learning & Memory · doi:10.1101/lm.028357.112 · Cited by 166 · see citing works
Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission
Rao, S., Schieber, A. M. P., O’Connor, C. P., Leblanc, M., Michel, D., & Ayres, J. S. (2017) · Cell · doi:10.1016/j.cell.2017.01.006 · Cited by 167 · see citing works
Dalli, J., Colas, R. A., Arnardottir, H. H., & Serhan, C. N. (2017) · Immunity · doi:10.1016/j.immuni.2016.12.009 · Cited by 161 · see citing works
Dysregulation of Inflammation, Neurobiology, and Cognitive Function in PTSD: An Integrative Review
Quinones, M., Gallegos, A. M., Lin, F., & Heffner, K. (2020) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-020-00782-9 · Cited by 85 · see citing works
Enteroendocrine cell signalling via the vagus nerve
Dockray, G. J. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.09.007 · Cited by 154 · see citing works
The effects of vitamin B on the immune/cytokine network and their involvement in depression
Mikkelsen, K., Stojanovska, L., Prakash, M. D., & Apostolopoulos, V. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.11.012 · Cited by 153 · see citing works
Neurobiology of resilience in depression: immune and vascular insights from human and animal studies
Dudek, K., Dion‐Albert, L., Kaufmann, F. N., Tuck, E., Lebel, M., & Ménard, C. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14547 · Cited by 156 · see citing works
Drug-Resistant Epilepsy and Surgery
Sheng, J., Shui, L., Qin, H., Li, B., & Zhang, X. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170504123316 · Cited by 151 · see citing works
Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system
Montgomery, K. L., Iyer, S. M., Christensen, A. J., Deisseroth, K., & Delp, S. L. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7577 · Cited by 147 · see citing works
Heart rate variability (HRV): From brain death to resonance breathing at 6 breaths per minute
Schwerdtfeger, A. R., Schwarz, G., Pfurtscheller, K., Thayer, J. F., Jarczok, M. N., & Pfurtscheller, G. (2019) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.11.013 · Cited by 147 · see citing works
Iron, Neuroinflammation and Neurodegeneration
Ward, R. J., Dexter, D. T., & Crichton, R. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137267 · Cited by 140 · see citing works
Brainstem dysfunction in critically ill patients
Benghanem, S., Mazeraud, A., Azabou, É., Chhor, V., Righy, C., Claassen, J., Rohaut, B., & Sharshar, T. (2020) · Critical Care · doi:10.1186/s13054-019-2718-9 · Cited by 138 · see citing works
The vagus nerve: An old but new player in brain-body communication.
Ma, L., Wang, H.-B., & Hashimoto, K. (2024) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2024.11.023 · Cited by 135 · see citing works
Systematic review of olfactory shifts related to obesity
Peng, M., Coutts, D., Wang, T., & Çakmak, Y. Ö. (2018) · Obesity Reviews · doi:10.1111/obr.12800 · Cited by 132 · see citing works
Brain-spleen axis in health and diseases: A review and future perspective
Wei, Y., Wang, T., Liao, L., Fan, X., Chang, L., & Hashimoto, K. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.008 · Cited by 134 · see citing works
Itch: A Paradigm of Neuroimmune Crosstalk
Wang, F., & Kim, B. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.008 · Cited by 130 · see citing works
The Biology of Physiological Health
Ayres, J. S. (2020) · Cell · doi:10.1016/j.cell.2020.03.036 · Cited by 129 · see citing works
The Microbiome-Gut-Brain Axis and Resilience to Developing Anxiety or Depression under Stress
Bear, T., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2021) · Microorganisms · doi:10.3390/microorganisms9040723 · Cited by 132 · see citing works
Stress-sensitive neural circuits change the gut microbiome via duodenal glands
Chang, H., Perkins, M. H., Novaes, L. S., Qian, F., Zhang, T., Neckel, P. H., Scherer, S., Ley, R. E., Han, W., & de Araújo, I. E. (2024) · Cell · doi:10.1016/j.cell.2024.07.019 · Cited by 133 · see citing works
Hu, P., Lü, Y., Pan, B., & Zhang, W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911076 · Cited by 125 · see citing works
Infection drives meningeal engraftment by inflammatory monocytes that impairs CNS immunity
Rua, R., Lee, J. Y., Silva, A. B., Swafford, I. S., Maric, D., Johnson, K. R., & McGavern, D. B. (2019) · Nature Immunology · doi:10.1038/s41590-019-0344-y · Cited by 123 · see citing works
The embodied mind: A review on functional genomic and neurological correlates of mind-body therapies
Muehsam, D. J., Lutgendorf, S. K., Mills, P. J., Rickhi, B., Chevalier, G., Bat, N., Chopra, D., & Gurfein, B. T. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.027 · Cited by 123 · see citing works
Mental Stress and Its Effects on Vascular Health
Sara, J. D. S., Toya, T., Ahmad, A., Clark, M. M., Gilliam, W. P., Lerman, L. O., & Lerman, A. (2022) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2022.02.004 · Cited by 135 · see citing works
The neuroscience of sadness: A multidisciplinary synthesis and collaborative review
Arias-López, J. A., Williams, C., Raghvani, R., Aghajani, M., Báez, S., Belzung, C., Booij, L., Busatto, G. F., Chiarella, J., Fu, C. H. Y., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.01.006 · Cited by 132 · see citing works
Obesity-induced inflammation: connecting the periphery to the brain
Le Thuc, O., & García-Cáceres, C. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01079-8 · Cited by 125 · see citing works
Exercise in Regulation of Inflammation-Immune Axis Function in Cancer Initiation and Progression.
Koelwyn, G. J., Wennerberg, E., Demaria, S., & Jones, L. W. (2015) · PubMed · Cited by 120 · see citing works
Microbiota in obesity: interactions with enteroendocrine, immune and central nervous systems
Mulders, R. J., de Git, K. C. G., Schéle, E., Dickson, S. L., Sanz, Y., & Adan, R. A. H. (2018) · Obesity Reviews · doi:10.1111/obr.12661 · Cited by 118 · see citing works
Systemic inflammation in traumatic spinal cord injury
Bloom, O., Herman, P. E., & Spungen, A. M. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113143 · Cited by 120 · see citing works
Neurobiology and systems biology of stress resilience
Kalisch, R., Russo, S. J., & Müller, M. B. (2024) · Physiological Reviews · doi:10.1152/physrev.00042.2023 · Cited by 135 · see citing works
Azabou, É., Navarro, V., Kubis, N., Gavaret, M., Heming, N., Cariou, A., Annane, D., Lofaso, F., Naccache, L., & Sharshar, T. (2018) · Critical Care · doi:10.1186/s13054-018-2104-z · Cited by 119 · see citing works
Schmalenberger, K., Eisenlohr-Moul, T., Würth, L., Schneider, E., Thayer, J., Ditzen, B., & Jarczok, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111946 · Cited by 104 · see citing works
Heart-rate-variability (HRV), predicts outcomes in COVID-19
Mol, M. B. A., Strous, M. T. A., van Osch, F., Vogelaar, F. J., Barten, D. G., Farchi, M. U., Foudraine, N. A., & Gidron, Y. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258841 · Cited by 118 · see citing works
Dynamics of T cell responses after stroke.
Gill, D., & Veltkamp, R. (2016) · Current opinion in pharmacology (Print) · doi:10.1016/j.coph.2015.09.009 · Cited by 116 · see citing works
Schneider, N., Chandran, P., Sundby, M., Visioli, F., Gonçalves, F. D. C., Burks, S. R., Paz, A. H. D. R., & Frank, J. A. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.033 · Cited by 117 · see citing works
Effects of dietary restriction on neuroinflammation in neurodegenerative diseases
Fontana, L., Ghezzi, L., Cross, A. H., & Piccio, L. M. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190086 · Cited by 116 · see citing works
Kemp, A. H., Koenig, J., & Thayer, J. F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.006 · Cited by 114 · see citing works
Kalinec, G. M., Lomberk, G. A., Urrutia, R. A., & Kalinec, F. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00192 · Cited by 115 · see citing works
Krishnan, M. L., Van Steenwinckel, J., Schang, A.-L., Yan, J., Arnadottir, J., Le Charpentier, T., Csaba, Z., Dournaud, P., Cipriani, S., Auvynet, C., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00422-w · Cited by 105 · see citing works
Huang, F., Dong, J., Kong, J., Wang, H., Meng, H., Spaeth, R. B., Camhi, S. S., Liao, X., Li, X., Zhai, X., et al. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-203 · Cited by 114 · see citing works
The Involvement of Parasympathetic and Sympathetic Nerve in the Inflammatory Reflex
Pereira, M. R., & Leite, P. E. C. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25307 · Cited by 113 · see citing works
Towards targeting resolution pathways of airway inflammation in asthma
Barnig, C., Frossard, N., & Levy, B. D. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.004 · Cited by 111 · see citing works
Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation
Naznin, F., Toshinai, K., Waise, T. M. Z., NamKoong, C., Moin, A. S. M., Sakoda, H., & Nakazato, M. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0139 · Cited by 102 · see citing works
Autoimmunity in postural orthostatic tachycardia syndrome: Current understanding
Vernino, S., & Stiles, L. E. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.04.005 · Cited by 107 · see citing works
Gut-brain communication and obesity: understanding functions of the vagus nerve
Berthoud, H., Albaugh, V. L., & Neuhuber, W. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143770 · Cited by 106 · see citing works
Silverman, H. A., Dancho, M. E., Regnier‐Golanov, A., Nasim, M. M., Ochani, M., Olofsson, P. S., Ahmed, M., Miller, E. J., Chavan, S. S., Golanov, E. V., et al. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00147 · Cited by 110 · see citing works
Self-citationCerritelli, F., Frasch, M. G., Antonelli, M. C., Viglione, C., Vecchi, S., Chiera, M., & Manzotti, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.721605 · Cited by 108 · see citing works
Zubcevic, J., Jun, J. Y., Kim, S., Perez, P. D., Afzal, A., Shan, Z., Li, W., Santisteban, M. M., Yuan, W., Febo, M., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02722 · Cited by 104 · see citing works
Saccaro, L. F., Schilliger, Z., Dayer, A. G., Perroud, N. A., & Piguet, C. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.017 · Cited by 104 · see citing works
Bioelectronic medicine: Preclinical insights and clinical advances
Pavlov, V. A., & Tracey, K. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.003 · Cited by 106 · see citing works
Self-citationLung innervation in the eye of a cytokine storm: neuroimmune interactions and COVID-19
Virgiliis, F. D., & Giovanni, S. D. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0402-y · Cited by 104 · see citing works
Medina-Rodriguez, E. M., Lowell, J. A., Worthen, R. J., Syed, S. A., & Beurel, E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00547 · Cited by 103 · see citing works
Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression
Bauer, M. E. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00178-w · Cited by 102 · see citing works
- Authors
- Pavlov, V. A., & Tracey, K. J.
- Affiliations
- Feinstein Institute for Medical Research (US)
- Corresponding author
- Pavlov, Valentin A.
- Venue
- Nature Reviews Endocrinology
- Published
- 2012-11-21
- Volume
- 8
- Issue
- 12
- Pages
- 743-754
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- PMC
- PMC4082307
- OpenAlex
- W1981020037
- Cited by
- 1,040
- References
- 148
- Citations by year
- 2026: 149 · 2025: 121 · 2024: 111 · 2023: 87 · 2022: 96 · 2021: 88 · 2020: 82 · 2019: 59 · 2018: 73 · 2017: 60 · 2016: 33 · 2015: 37 · 2014: 25 · 2013: 17 · 2012: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM089807, R01GM057226)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- vagus nerve, cholinergic anti-inflammatory pathway, obesity, chronic inflammation, insulin resistance, type 2 diabetes, metabolic homeostasis, immune activation, vagus nerve stimulation therapy
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Homeostasis, Humans, Inflammation, Obesity, Reflex, Vagus Nerve, Signal Transduction, Metabolic Networks and Pathways
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