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Cited by 605Thyroid Disorders and TreatmentsBirth, Development, and HealthDown syndrome and intellectual disability research

The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.

Timing of Thyroid Hormone Action in the Developing Brain: Clinical Observations and Experimental Findings

Zoeller, R. T., Rovet, J.·2004·Journal of Neuroendocrinology
DOI 10.1111/j.1365-2826.2004.01243.x
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Abstract

Abstract The original concept of the critical period of thyroid hormone (TH) action on brain development was proposed to identify the postnatal period during which TH supplement must be provided to a child with congenital hypothyroidism to prevent mental retardation. As neuropsychological tools have become more sensitive, it has become apparent that even mild TH insufficiency in humans can produce measurable deficits in very specific neuropsychological functions, and that the specific consequences of TH deficiency depends on the precise developmental timing of the deficiency. Models of maternal hypothyroidism, hypothyroxinaemia and congenital hyperthyroidism have provided these insights. If the TH deficiency occurs early in pregnancy, the offspring display problems in visual attention, visual processing (i.e. acuity and strabismus) and gross motor skills. If it occurs later in pregnancy, children are at additional risk of subnormal visual (i.e. contrast sensitivity) and visuospatial skills, as well as slower response speeds and fine motor deficits. Finally, if TH insufficiency occurs after birth, language and memory skills are most predominantly affected. Although the experimental literature lags behind clinical studies in providing a mechanistic explanation for each of these observations, recent studies confirm that the specific action of TH on brain development depends upon developmental timing, and studies informing us about molecular mechanisms of TH action are generating hypotheses concerning possible mechanisms to account for these pleiotropic actions.

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Crossref · 10.1111/j.1365-2826.2004.01243.x

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Research works printed but not linked: 10

  1. 10.1111/j.1469-8749.1999.tb00561.x · DOI
  2. 10.1037/0012-1649.23.4.490 · DOI
  3. 10.1111/j.1469-8749.1999.tb00652.x · DOI
  4. Ishaik G, 2000, Hypothyroxinemia of prematurity and the development of attention and memory in infants with low risk prematurity. A pilot study, J Devel Behav Pediatr, 21, 172
  5. 10.1111/j.1469-8749.1999.tb00560.x · DOI
  6. 10.1073/pnas.062413299 · DOI
  7. 10.1210/me.15.7.1170 · DOI
  8. 10.1210/en.143.4.1346 · DOI
  9. 10.1210/en.143.4.1554 · DOI
  10. Herzig CTA, 2001, Notch signaling is reduced in fetal rat brain by maternal hypothyroidism, Neurotoxicology, 22, Abstract

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Metadata

Authors
Zoeller, R. T., & Rovet, J.
Affiliations
  • University of Massachusetts Amherst (US)
  • University of Toronto (CA)
Corresponding author
  • Zoeller, R. T.
  • Rovet, J.
ORCID
Venue
Journal of Neuroendocrinology
Publisher
Wiley
Published
2004-10
Volume
16
Issue
10
Pages
809-818
ISSN
  • 0953-8194 (ISSN-L)
  • 1365-2826
DOI
10.1111/j.1365-2826.2004.01243.x
OpenAlex
W2052693888
Cited by
605
References
167
Citations by year
2026: 19 · 2025: 17 · 2024: 22 · 2023: 16 · 2022: 23 · 2021: 31 · 2020: 24 · 2019: 33 · 2018: 33 · 2017: 35 · 2016: 39 · 2015: 32 · 2014: 33 · 2013: 33 · 2012: 44
FWCI
2.48
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 19 d)
Locations
  • Journal of Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • March of Dimes Foundation
  • National Institutes of Health
  • Canadian Institutes of Health Research
  • National Institute of Environmental Health Sciences (ES10026)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Keywords
thyroid hormones, brain development, critical period, congenital hypothyroidism, maternal hypothyroidism, congenital hyperthyroidism, neuropsychological deficits, visual processing, strabismus, visuospatial ability, language and memory, developmental timing
MeSH terms
Animals, Brain, Female, Frontal Lobe, Humans, Pregnancy, Receptors, Thyroid Hormone, Thyroid Hormones

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