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Brief Treatment With the Glucocorticoid Receptor Antagonist Mifepristone Normalises the Corticosterone‐Induced Reduction of Adult Hippocampal Neurogenesis
Abstract
The glucocorticoid receptor antagonist mifepristone has been shown to rapidly and effectively ameliorate symptoms of psychotic major depression. To better understand its mechanism, we investigated mifepristone's cellular effects, and found that it rapidly reversed a chronic corticosterone‐induced reduction of adult neurogenesis in rats. Unlike other antidepressants, mifepristone is particularly potent in a high corticosterone environment. These data indicate that similarly to its clinical efficacy, mifepristone's effects on adult neurogenesis are rapid and positive, and may therefore be important for its mechanism of action.
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Cites
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Adult brain neurogenesis and psychiatry: a novel theory of depression
Jacobs, B. L., van Praag, H., & Gage, F. H. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000712 · Cited by 964
Young, A. H., Gallagher, P., Watson, S., Del-Estal, D., Owen, B. M., & Nicol Ferrier, I. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300471 · Cited by 318
Clinical and Biological Effects of Mifepristone Treatment for Psychotic Depression
Flores, B. H., Kenna, H., Keller, J., Solvason, H. B., & Schatzberg, A. F. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300884 · Cited by 203
Cited by
Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Anacker, C., & Hen, R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.45 · Cited by 1,014
The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?
Anacker, C., Zunszain, P. A., Carvalho, L. A., & Pariante, C. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.007 · Cited by 592
Stress Hormone Regulation: Biological Role and Translation into Therapy
Holsboer, F., & Ising, M. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100321 · Cited by 473
Structural Plasticity and Hippocampal Function
Leuner, B., & Gould, E. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100359 · Cited by 455
Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Fuchs, E., Oomen, C. A., & Czéh, B. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.08.003 · Cited by 449
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Metadata
- Authors
- Mayer, J. L., Klumpers, L., Maslam, S., De Kloet, E. R., Joëls, M., & Lucassen, P. J.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2006-06-21
- Volume
- 18
- Issue
- 8
- Pages
- 629-631
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2110552899
- Cited by
- 181
- References
- 4
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mayer, J. L., Klumpers, L., Maslam, S., De Kloet, E. R., Joëls, M., & Lucassen, P. J. (2006). Brief Treatment With the Glucocorticoid Receptor Antagonist Mifepristone Normalises the Corticosterone‐Induced Reduction of Adult Hippocampal Neurogenesis. Journal of Neuroendocrinology. https://doi.org/10.1111/j.1365-2826.2006.01455.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
