Cited by 1,014Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood

Open access
Anacker, Christoph, Hen, René·2017·Nature Reviews Neuroscience

Abstract

Adult hippocampal neurogenesis has been implicated in cognitive processes, such as pattern separation, and in the behavioural effects of stress and antidepressants. Young adult-born neurons have been shown to inhibit the overall activity of the dentate gyrus by recruiting local interneurons, which may result in sparse contextual representations and improved pattern separation. We propose that neurogenesis-mediated inhibition also reduces memory interference and enables reversal learning both in neutral situations and in emotionally charged ones. Such improved cognitive flexibility may in turn help to decrease anxiety-like and depressive-like behaviour.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/nrn.2017.45

Cites

191 of 191 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Findings in mood disorders reveal alterations at the levels of intracellular signaling, gene expression, neurotrophic factors, neurogenesis, neuroinflammation, excitatory and inhibitory neurotransmission, and synaptic number and function in several brain regions implicated in depression.

    “These findings reveal alterations at the levels of intracellular signaling, gene expression, neurotrophic factors, neurogenesis, neuroinflammation, excitatory and inhibitory neurotransmission, and synaptic number and function, and have been described in several brain regions implicated in depression 13-22 .”

    From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [19]

    The section on antidepressant effects of neurogenesis discusses hippocampal neurogenesis, neurotrophic signalling and inhibitory activity in the dentate gyrus. The section on targetable endophenotypes also describes depression as biologically heterogeneous. Neither passage supports the full list of alterations—particularly neuroinflammation and synaptic number and function—or establishes that they occur across several brain regions implicated in depression. Page numbers are unavailable in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured
  • Hippocampal neurogenesis-mediated inhibition has been proposed as a mechanism to reduce memory interference-enabling cognitive flexibility in tasks such as reversal learning.

    “Hippocampal neurogenesis-mediated inhibition has been proposed as a mechanism to reduce memory interference—enabling cognitive flexibility in tasks such as reversal learning [76], which we have previously shown is sensitive to reductions of Cyfip1 in the rat [11].”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Anacker, C., & Hen, R.
Affiliations
Research Foundation For Mental Hygiene (US)
Corresponding author
  • Anacker, Christoph
  • Hen, René
Venue
Nature Reviews Neuroscience
Published
2017-05-04
Volume
18
Issue
6
Pages
335-346
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2610621727
Cited by
1,014
References
191
Citations by year
2026: 89 · 2025: 114 · 2024: 104 · 2023: 133 · 2022: 142 · 2021: 125 · 2020: 126 · 2019: 93 · 2018: 64 · 2017: 21 · 2016: 1 · 2012: 1
FWCI
12.57
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Veterans Affairs (CDP 13-003)
  • National Institute on Aging (R01AG043688)
  • National Institute of Mental Health (R37MH068542, R01MH083862, K99MH108719)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
adult hippocampal neurogenesis, dentate gyrus, cognitive flexibility, pattern separation, mood disorders, local interneurons, context representation, memory interference, reversal learning, stress, antidepressants, anxiety-like behavior, depression-like behavior
MeSH terms
Affect, Animals, Cognition, Hippocampus, Humans, Memory, Mice, Rats, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review