Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
Open accessAbstract
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as pattern separation, and in the behavioural effects of stress and antidepressants. Young adult-born neurons have been shown to inhibit the overall activity of the dentate gyrus by recruiting local interneurons, which may result in sparse contextual representations and improved pattern separation. We propose that neurogenesis-mediated inhibition also reduces memory interference and enables reversal learning both in neutral situations and in emotionally charged ones. Such improved cognitive flexibility may in turn help to decrease anxiety-like and depressive-like behaviour.
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Findings in mood disorders reveal alterations at the levels of intracellular signaling, gene expression, neurotrophic factors, neurogenesis, neuroinflammation, excitatory and inhibitory neurotransmission, and synaptic number and function in several brain regions implicated in depression.
“These findings reveal alterations at the levels of intracellular signaling, gene expression, neurotrophic factors, neurogenesis, neuroinflammation, excitatory and inhibitory neurotransmission, and synaptic number and function, and have been described in several brain regions implicated in depression 13-22 .”
From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [19]
The section on antidepressant effects of neurogenesis discusses hippocampal neurogenesis, neurotrophic signalling and inhibitory activity in the dentate gyrus. The section on targetable endophenotypes also describes depression as biologically heterogeneous. Neither passage supports the full list of alterations—particularly neuroinflammation and synaptic number and function—or establishes that they occur across several brain regions implicated in depression. Page numbers are unavailable in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredHippocampal neurogenesis-mediated inhibition has been proposed as a mechanism to reduce memory interference-enabling cognitive flexibility in tasks such as reversal learning.
“Hippocampal neurogenesis-mediated inhibition has been proposed as a mechanism to reduce memory interference—enabling cognitive flexibility in tasks such as reversal learning [76], which we have previously shown is sensitive to reductions of Cyfip1 in the rat [11].”
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- Authors
- Anacker, C., & Hen, R.
- Affiliations
- Research Foundation For Mental Hygiene (US)
- Corresponding author
- Anacker, Christoph
- Hen, René
- Venue
- Nature Reviews Neuroscience
- Published
- 2017-05-04
- Volume
- 18
- Issue
- 6
- Pages
- 335-346
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC6261347
- OpenAlex
- W2610621727
- Cited by
- 1,014
- References
- 191
- Citations by year
- 2026: 89 · 2025: 114 · 2024: 104 · 2023: 133 · 2022: 142 · 2021: 125 · 2020: 126 · 2019: 93 · 2018: 64 · 2017: 21 · 2016: 1 · 2012: 1
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (CDP 13-003)
- National Institute on Aging (R01AG043688)
- National Institute of Mental Health (R37MH068542, R01MH083862, K99MH108719)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult hippocampal neurogenesis, dentate gyrus, cognitive flexibility, pattern separation, mood disorders, local interneurons, context representation, memory interference, reversal learning, stress, antidepressants, anxiety-like behavior, depression-like behavior
- MeSH terms
- Affect, Animals, Cognition, Hippocampus, Humans, Memory, Mice, Rats, Neurogenesis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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