The regulation of seasonal changes in food intake and body weight
Open accessAbstract
Seasonal rhythms of body weight, reflecting altered food intake, energy storage and expenditure, are a common feature of mammals inhabiting temperate and arctic latitudes. They have evolved so that predictable annual changes in the external environment can be anticipated and animals can adjust their physiology and behaviour in preparation for the changing demands of the seasons. These long-term changes in energy balance are not simply effected by the brain centres and peptidergic pathways known to underlie short-term homeostatic regulation. Screens of altered gene expression in Siberian hamsters comparing the anabolic summer state in long photoperiods and the catabolic 'winter' state in short photoperiods have identified differential gene expression in the hypothalamus. The majority of gene expression changes are confined to two restricted areas: the dorsomedial posterior arcuate nucleus, and the ventral ependymal layer of the third ventricle. Functions encoded by these 'seasonal' genes include thyroid hormone metabolism, retinoic acid and histaminergic signalling, and VGF and secretogranin production. The changes in thyroid hormone availability that are brought about by differential activity of deiodinase enzymes are of particular importance because experimental manipulation of central thyroid levels can prevent seasonal cyclicity. Given the importance of thyroid hormone in the initial development of the brain, we hypothesise that thyroid hormone-dependent plasticity of hypothalamic connections and neurogenesis underlie seasonal cycles of food intake and body weight.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Animals regulate development and reproduction according to environmental cues such as season, temperature, moon phase, and food availability.
“Animals regulate development and reproduction according to environmental cues such as season, temperature, moon phase, and food availability (1–5).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [3]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
The role of histamine and the tuberomamillary nucleus in the nervous system
Haas, H. L., & Panula, P. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1034 · Cited by 914 · see citing works
Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance
Kokoeva, M. V., Yin, H., & Flier, J. S. (2005) · Science · doi:10.1126/science.1115360 · Cited by 704 · see citing works
Thyroid hormone receptors in brain development and function
Bernal, J. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0424 · Cited by 696 · see citing works
Seasonal Breeding: Nature's Contraceptive
Lincoln, G. A., & Short, R. V. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-571136-4.50007-3 · Cited by 612 · see citing works
Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds
Yoshimura, T., Yasuo, S., Watanabe, M., Iigo, M., Yamamura, T., Hirunagi, K., & Ebihara, S. (2003) · Nature · doi:10.1038/nature02117 · Cited by 561 · see citing works
Unraveling the central nervous system pathways underlying responses to leptin
Elmquist, J. K., Maratos-Flier, E., Saper, C. B., & Flier, J. S. (1998) · Nature Neuroscience · doi:10.1038/2164 · Cited by 520 · see citing works
Hypothalamic tanycytes: a key component of brain-endocrine interaction
RODRIGUEZ, E., BLAZQUEZ, J., PASTOR, F., PELAEZ, B., PENA, P., PERUZZO, B., & AMAT, P. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)47003-5 · Cited by 475 · see citing works
Barrett, P., Ebling, F. J. P., Schuhler, S., Wilson, D., Ross, A. W., Warner, A., Jethwa, P., Boelen, A., Visser, T. J., Ozanne, D. M., et al. (2007) · Endocrinology · doi:10.1210/en.2007-0316 · Cited by 286 · see citing works
Self-citationRheostasis; the physiology of change
(1991) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(91)90337-c · Cited by 203 · see citing works
Prévot, V., Croix, D., Bouret, S. G., Dutoit, S., Tramu, G., Stefano, G. B., & Beauvillain, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00383-8 · Cited by 198 · see citing works
Malpaux, B., Daveau, A., Maurice, F., Duarte, G. A., & Chemineau, P. (1998) · Endocrinology · doi:10.1210/endo.139.4.5879 · Cited by 191 · see citing works
The Road We Travelled: Discovery, Choreography, and Significance of Brain Replaceable Neurons
Nottebohm, F. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1298.027 · Cited by 170 · see citing works
Steinlechner, S., Heldmaier, G., & Becker, H. F. (1983) · Oecologia · doi:10.1007/bf00376859 · Cited by 149 · see citing works
Maywood, E. S., & Hastings, M. H. (1995) · Endocrinology · doi:10.1210/endo.136.1.7828525 · Cited by 145 · see citing works
Follett, B. K., & Nicholls, T. J. (1985) · Journal of Endocrinology · doi:10.1677/joe.0.1070211 · Cited by 124 · see citing works
Maywood, E. S., Bittman, E. L., & Hastings, M. H. (1996) · Biology of Reproduction · doi:10.1095/biolreprod54.2.470 · Cited by 123 · see citing works
Reddy, A. B., Cronin, A. S., Ford, H., & Ebling, F. J. P. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00746.x · Cited by 117 · see citing works
Self-citationDruce, M. R. (2005) · Archives of Disease in Childhood · doi:10.1136/adc.2005.073759 · Cited by 113 · see citing works
Barrett, P., Ivanova, E., Graham, E. S., Ross, A., Wilson, D., Plé, H., Mercer, J. G., Ebling, F. J. P., Schuhler, S., Dupré, S. M., et al. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06929 · Cited by 111 · see citing works
Self-citationJansen, H. T., Cutter, C., Hardy, S. L., Lehman, M. N., & Goodman, R. L. (2003) · Endocrinology · doi:10.1210/en.2002-0188 · Cited by 108 · see citing works
Yasuo, S., Nakao, N., Ohkura, S., Iigo, M., Hagiwara, S., Goto, A., Andō, H., Yamamura, T., Watanabe, M., Watanabe, T., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0507 · Cited by 106 · see citing works
Role of Thyroid Hormone Deiodination in the Hypothalamus
Lechan, R. M., & Fekete, C. (2005) · Thyroid · doi:10.1089/thy.2005.15.883 · Cited by 104 · see citing works
Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist
Hancock, A. A., Bennani, Y. L., Bush, E. N., et al. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.01.015 · Cited by 99 · see citing works
Friesema, E. C. H., Jansen, J., & Visser, T. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330228 · Cited by 97 · see citing works
Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse
Ivanova, E. A., Bechtold, D. A., Dupré, S. M., Brennand, J. C., Barrett, P., Luckman, S. M., & Loudon, A. S. I. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00199.2007 · Cited by 97 · see citing works
Self-citationRousseau, K., Atcha, Z., Cagampang, F. R. A., Rouzic, P. L., Stirland, J. A., Ivanov, T. R., Ebling, F. J. P., Klingenspor, M., & Loudon, A. S. I. (2002) · Endocrinology · doi:10.1210/endo.143.8.8967 · Cited by 96 · see citing works
Self-citationRegional differences in fat pad responses to short days in Siberian hamsters
Bartness, T. J., Hamilton, J. M., Wade, G. N., & Goldman, B. D. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.257.6.r1533 · Cited by 95 · see citing works
Mercer, J. G., & Speakman, J. R. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00053-1 · Cited by 94 · see citing works
Mercer, J. G., Moar, K. M., Logie, T. J., Findlay, P. A., Adam, C. L., & Morgan, P. J. (2001) · Endocrinology · doi:10.1210/endo.142.10.8454 · Cited by 94 · see citing works
Lincoln, G. A., Andersson, H., & Hazlerigg, D. G. (2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.00990.x · Cited by 92 · see citing works
Ross, A., Webster, C. A., Mercer, J. G., Moar, K. M., Ebling, F. J. P., Schuhler, S., Barrett, P., & Morgan, P. J. (2003) · Endocrinology · doi:10.1210/en.2003-0838 · Cited by 92 · see citing works
Self-citationEbling, F. J. P. (1994) · General and Comparative Endocrinology · doi:10.1006/gcen.1994.1147 · Cited by 91 · see citing works
Self-citationRheostasis; the physiology of change
(1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90603-4 · Cited by 91 · see citing works
The Selenoenzyme Family of Deiodinase Isozymes Controls Local Thyroid Hormone Availability
Köhrle, J. (2000) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1010012419869 · Cited by 89 · see citing works
Barrett, P., Ross, A., Balík, A., et al. (2004) · Endocrinology · doi:10.1210/en.2004-1452 · Cited by 88 · see citing works
Self-citationVGF-Derived Peptide, TLQP-21, Regulates Food Intake and Body Weight in Siberian Hamsters
Jethwa, P. H., Warner, A., Nilaweera, K. N., et al. (2007) · Endocrinology · doi:10.1210/en.2007-0038 · Cited by 86 · see citing works
Xiong, J.-J., Karsch, F. J., & Lehman, M. N. (1997) · Endocrinology · doi:10.1210/endo.138.3.5000 · Cited by 86 · see citing works
Malpaux, B. (1998) · Endocrinology · doi:10.1210/en.139.4.1508 · Cited by 84 · see citing works
Control of torpor and body weight patterns by a seasonal timer in Siberian hamsters
Bartness, T. J., Elliott, J. A., & Goldman, B. D. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.257.1.r142 · Cited by 80 · see citing works
Malmlöf, K., Zaragoza, F., Golozoubova, V., et al. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803036 · Cited by 78 · see citing works
Atcha, Z., Cagampang, F. R. A., Stirland, J. A., Morris, I. D., Brooks, A. N., Ebling, F. J. P., Klingenspor, M., & Loudon, A. S. I. (2000) · Endocrinology · doi:10.1210/endo.141.11.7769 · Cited by 74 · see citing works
Self-citationMercer, J. G., Lawrence, C. B., Beck, B., et al. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.269.5.r1099 · Cited by 73 · see citing works
Ebling, F. J. P., Arthurs, O. J., Turney, B. W., & Cronin, A. S. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00253.x · Cited by 56 · see citing works
Self-citationRobson, A. J., Rousseau, K., Loudon, A. S. I., et al. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00830.x · Cited by 55 · see citing works
Maywood, E. S., Bittman, E. L., Ebling, F. J. P., et al. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00750.x · Cited by 51 · see citing works
Self-citationWhat can we learn from seasonal animals about the regulation of energy balance?
Morgan, P. J., Ross, A., Mercer, J. G., et al. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53019-5 · Cited by 50 · see citing works
D'Costa, A. P., Prevette, D. M., Houenou, L. J., Wang, S., Zackenfels, K., Rohrer, H., Zapf, J., Caroni, P., & Oppenheim, R. W. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19980905)36:3 · Cited by 49 · see citing works
Photoperiodic Signalling Through the Melatonin Receptor Turns Full Circle
Morgan, P. J., & Hazlerigg, D. G. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01724.x · Cited by 46 · see citing works
Horton, T. H., Buxton, O. M., Losee-Olson, S. H., et al. (2000) · Hormones and Behavior · doi:10.1006/hbeh.2000.1592 · Cited by 44 · see citing works
Mercer, J. G., & Tups, A. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.091 · Cited by 41 · see citing works
Schuhler, S., Warner, A., Finney, N. S., Bennett, G. W., Ebling, F. J. P., & Brameld, J. M. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01524.x · Cited by 38 · see citing works
Self-citationXiong, J.-J. (1997) · Endocrinology · doi:10.1210/en.138.3.1240 · Cited by 36 · see citing works
Hypothalamic Thyroid Hormones: Mediators of Seasonal Physiology
Bechtold, D. A., & Loudon, A. S. I. (2007) · Endocrinology · doi:10.1210/en.2007-0596 · Cited by 33 · see citing works
Ebling, F. J. P., Wilson, D. M., Wood, J., Hughes, D. R., Mercer, J. G., Morgan, P. J., & Barrett, P. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01702.x · Cited by 29 · see citing works
Self-citationDecrease of food intake by MC4-R agonist MTII in Siberian hamsters in long and short photoperiods
Schuhler, S., Horan, T. L., Hastings, M. H., Mercer, J. G., Morgan, P. J., & Ebling, F. J. P. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00331.2002 · Cited by 26 · see citing works
Self-citationThyroid hormone regulates the expression of SNAP-25 during rat brain development
Zhang, H., Su, Q., & Luo, M. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9596-1 · Cited by 25 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Morgan PJ Photoperiodic signalling beyond the melatonin receptor. J Neuroendocrinol 2008; 20: in press.
- Bartness TJ, Goldman BD, Bittman EL. Suprachiasmatic nucleus lesions block responses to systemic melatonin infusions in Siberian hamsters. Am J Physiol 1991; 260: R102-R112.
- Ebling FJP, Wilson D, Wilson D, Wood J, Hughes D, Mercer JG, Morgan PJ, Barrett P Localisation of the TRH secretory system in the Siberian hamster. J Neuroendocrinol 2008; 20: 576-586.
- Barrett P, Ivanova E, Graham ES, Ross AW, Wilson D, Ple H, Mercer JG, Ebling FJP, Schuhler S, Dupre SM, Loudon ASI, Morgan PJ. Photoperiodic regulation of GPR50, Nestin and CRBP1 in tanycytes of the third ventri- cle ependymal layer of the Siberian hamster. J Endocr 2006; 191: 687- 698.
- Huang L, De Vries GJ, Bittman EL. Photoperiod regulates neuronal bromodeoxyuridine labeling in the brain of a seasonally breeding mam- mal. J Neurobiol 1998; 36: 410-420.
Cited by
Sorted by citations
Shearer, K. D., Stoney, P. N., Morgan, P. J., & McCaffery, P. J. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.005 · Cited by 152 · see citing works
Daily and seasonal adaptation of the circadian clock requires plasticity of the SCN neuronal network
Meijer, J. H., Michel, S., VanderLeest, H. T., & Rohling, J. H. T. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07522.x · Cited by 119 · see citing works
Acute Induction of Eya3 by Late-Night Light Stimulation Triggers TSHβ Expression in Photoperiodism
Masumoto, K.-H., Ukai-Tadenuma, M., Kasukawa, T., Nagano, M., Uno, K. D., Tsujino, K., Horikawa, K., Shigeyoshi, Y., & Ueda, H. R. (2010) · Current Biology · doi:10.1016/j.cub.2010.11.038 · Cited by 118 · see citing works
Murphy, M., Jethwa, P. H., Warner, A., Barrett, P., Nilaweera, K. N., Brameld, J. M., & Ebling, F. J. P. (2012) · Endocrinology · doi:10.1210/en.2011-1249 · Cited by 107 · see citing works
Self-citationAndreatta, G., Broyart, C., Borghgraef, C., Vadiwala, K., Kozin, V., Polo, A., Bileck, A., Beets, I., Schoofs, L., Gerner, C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910262116 · Cited by 61 · see citing works
Whole Blood Transcriptome Analysis Reveals Footprints of Cattle Adaptation to Sub-Arctic Conditions
Pokharel, K., Weldenegodguad, M., Popov, R., Honkatukia, M., Huuki, H., Lindeberg, H., Peippo, J., Reilas, T., Zarovnyaev, S., & Kantanen, J. (2019) · Animal Genetics · doi:10.1111/age.12783 · Cited by 23 · see citing works
- Authors
- Ebling, F. J. P., & Barrett, P.
- Affiliations
- University of Nottingham (GB)
- University of Aberdeen (GB)
- Corresponding author
- Ebling, F. J. P.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2008-06
- Volume
- 20
- Issue
- 6
- Pages
- 827-833
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2019911667
- Cited by
- 139
- References
- 59
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 18 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 8 · 2015: 6 · 2014: 12 · 2013: 9 · 2012: 15
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission (LSHM‐CT‐2003‐503041)
- Biotechnology and Biological Sciences Research Council (S17106)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- seasonal rhythms, dietary intake, body weight, energy balance, Siberian hamster, photoperiod, hypothalamus, arcuate nucleus, third ventricle, thyroid hormones, deiodinases, retinoic acid, VGF, secretogranin, gene expression
- MeSH terms
- Animals, Body Weight, Circadian Rhythm, Eating, Energy Metabolism, Cricetinae, Homeostasis, Hypothalamus, Neuronal Plasticity, Seasons, Thyroid Hormones, Photoperiod, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
