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Evidence for Suprachiasmatic Vasopressin Neurones Innervating Kisspeptin Neurones in the Rostral Periventricular Area of the Mouse Brain: Regulation by Oestrogen
Open accessAbstract
In rodents, a circadian signal from the suprachiasmatic nucleus (SCN) is essential for the pro‐oestrous surge of gonadotrophin‐releasing hormone (GnRH), which, in turn, induces luteinising hormone (LH) surge and ovulation. We hypothesised that kisspeptin (KP) neurones in the anteroventral periventricular and periventricular preoptic nuclei (AVPV/PeN) form part of the communication pathway between the SCN and GnRH neurones. In anterograde track tracing studies, we first identified vasopressin (VP)‐containing axons of SCN origin in apposition to KP‐immunoreactive (IR) neurones. Studies to quantify this input relied on the observation that VP‐synthesising neurones in the SCN differ from other VP systems in their lack of galanin expression. In ovariectomised mice, 30.79 ± 1.63% of KP‐IR perikarya and proximal dendrites within the AVPV/PeN received galanin‐negative VP‐IR varicosities. Oestrogen‐treatment significantly increased the number of KP‐IR neurones, with their percentage apposed by galanin‐negative VP‐IR varicosities (46.95 ± 1.88%) and the number of VP‐IR appositions on individual KP‐IR neurones. At the ultrastructural level, the VP‐IR terminals formed symmetric synapses with KP‐IR neurones, which was in accordance with the morphology of inhibitory synapses established by SCN neurones. By contrast to VP, vasoactive intestinal polypeptide (VIP), which is synthesised by a distinct subset of SCN neurones, occurred only rarely in axons apposed to KP‐IR neurones. Altogether, our results are consistent with the hypothesis that KP neurones located in the mouse AVPV/PeN receive circadian information from the SCN via a vasopressinergic monosynaptic pathway, which is enhanced by oestrogen.
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“However, E2 restores AVP-induced activation of kisspeptin neurons in the AVPV/PeN in ovariectomized (OVX) female mice49,50”
From Emerging insights into hypothalamic‐pituitary‐gonadal axis regulation and interaction with stress signalling (2018) · cites this paper as [50]
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Regulation of Kiss1 gene expression in the brain of the female mouse
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Multimodal Influence of Estrogen upon Gonadotropin-Releasing Hormone Neurons
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Wintermantel, T. M., Campbell, R. E., Porteous, R. W., Bock, D., Gröne, H., Todman, M. G., Korach, K. S., Greiner, E. F., Pérez, C. A., Schütz, G., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.023 · Cited by 598
ADACHI, S., YAMADA, S., TAKATSU, Y., MATSUI, H., KINOSHITA, M., TAKASE, K., SUGIURA, H., OHTAKI, T., MATSUMOTO, H., UENOYAMA, Y., et al. (2007) · Journal of Reproduction and Development · doi:10.1262/jrd.18146 · Cited by 580
GABA is the principal neurotransmitter of the circadian system
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Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
Pinilla, L., Aguilar, E., Diéguez, C., Millar, R. P., & Tena‐Sempere, M. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2010 · Cited by 843
Control of puberty onset and fertility by gonadotropin-releasing hormone neurons
Herbison, A. E. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.70 · Cited by 515
Sex differences in circadian timing systems: implications for disease
Bailey, M., & Silver, R. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.003 · Cited by 348
Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018) · Journal of neuroendocrinology · doi:10.1111/jne.12590 · Cited by 298
Physiology of the Adult Gonadotropin-Releasing Hormone Neuronal Network
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Metadata
- Authors
- Vida, B., Deli, L., Hrabovszky, E., Kalamatianos, T., Caraty, A., Coen, C. W., Liposits, Z., & Kalló, I.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- Physiologie de la Reproduction et des Comportements (FR)
- King's College London (GB)
- Pázmány Péter Catholic University (HU)
- Corresponding author
- Kalló, I.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2010-08-19
- Volume
- 22
- Issue
- 9
- Pages
- 1032-1039
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2165214665
- Cited by
- 156
- References
- 50
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 10 · 2021: 20 · 2020: 8 · 2019: 12 · 2018: 9 · 2017: 8 · 2016: 9 · 2015: 14 · 2014: 9 · 2013: 20 · 2012: 11
- FWCI
- 16.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Science Foundation
- Wellcome Trust (060202)
- European Commission (LSHM‐CT‐2003‐503041)
- Hungarian Scientific Research Fund
- Biotechnology and Biological Sciences Research Council (BB/D523186/1)
- National Institute of Neurological Disorders and Stroke
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- suprachiasmatic nucleus, kisspeptin neurons, vasopressin, estrogen, circadian regulation, GnRH surge, galanin, vasoactive intestinal peptide, inhibitory synapses, monosynaptic pathway, ovariectomy
- MeSH terms
- Animals, Brain, Estradiol, Female, Male, Neurons, Phytohemagglutinins, Suprachiasmatic Nucleus, Synapses, Vasopressins, Intralaminar Thalamic Nuclei, Tumor Suppressor Proteins, Mice, Kisspeptins
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