Selective Oestrogen Receptor Modulators Differentially Potentiate Brain Mitochondrial Function

Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer’s disease

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Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

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Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

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Pyrazole Ligands: Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists

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Estrogen Receptor-β Potency-Selective Ligands: Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues

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Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

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Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

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Mitochondrial localization of estrogen receptor β

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Distribution of estrogen receptor β immunoreactivity in the rat central nervous system

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Novel Actions of Estrogen Receptor-β on Anxiety-Related Behaviors

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Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

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The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications

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Estrogen Increases Mitochondrial Efficiency and Reduces Oxidative Stress in Cerebral Blood Vessels

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Estrogen-induced plasticity from cells to circuits: predictions for cognitive function

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An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation

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Progesterone and Estrogen Regulate Oxidative Metabolism in Brain Mitochondria

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Mechanism of estrogen-mediated neuroprotection: Regulation of mitochondrial calcium and Bcl-2 expression

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Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons

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Neuroprotection mediated through estrogen receptor-α in astrocytes

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Response-Specific and Ligand Dose-Dependent Modulation of Estrogen Receptor (ER) α Activity by ERβ in the Uterus

Frasor, J. M., Barnett, D., Danes, J. M., Hess, R., Parlow, A. F., & Katzenellenbogen, B. S. (2003) · Endocrinology · doi:10.1210/en.2002-0143 · Cited by 232 · see citing works

Estrogen Receptor Protein Interaction with Phosphatidylinositol 3-Kinase Leads to Activation of Phosphorylated Akt and Extracellular Signal-Regulated Kinase 1/2 in the Same Population of Cortical Neurons: A Unified Mechanism of Estrogen Action

Mannella, P., & Brinton, R. D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1443-06.2006 · Cited by 213 · see citing works

Cellular and subcellular localization of estrogen and progestin receptor immunoreactivities in the mouse hippocampus

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Estradiol In Vivo Regulation of Brain Mitochondrial Proteome

Nilsen, J., Irwin, R., Gallaher, T., & Brinton, R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4391-07.2007 · Cited by 177 · see citing works

Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function

Nilsen, J., Chen, S., Irwin, R. W., Iwamoto, S. J., & Brinton, R. D. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-74 · Cited by 175 · see citing works

Mitochondria as Therapeutic Targets of Estrogen Action in the Central Nervous System

Nilsen, J., & Brinton, R. D. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337193 · Cited by 166 · see citing works

Binding of MCF‐7 cell mitochondrial proteins and recombinant human estrogen receptors α and β to human mitochondrial dna estrogen response elements

Chen, J. Q., Eshete, M., Alworth, W. L., & Yager, J. D. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20178 · Cited by 142 · see citing works

Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid

Yao, J., Irwin, R. W., Chen, S., Hamilton, R., Cadenas, E., & Brinton, R. D. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.001 · Cited by 133 · see citing works

17β-estradiol induces Ca2+ influx, dendritic and nuclear Ca2+ rise and subsequent cyclic AMP response element-binding protein activation in hippocampal neurons: A potential initiation mechanism for estrogen neurotrophism

Zhao, L.-Q., Chen, S.-H., Wang, M. J., & Brinton, R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.11.054 · Cited by 129 · see citing works

Distribution and localization patterns of estrogen receptor‐β and insulin‐like growth factor‐1 receptors in neurons and glial cells of the female rat substantia nigra: Localization of ERβ and IGF‐1R in substantia nigra

Quesada, A., Romeo, H. E., & Micevych, P. E. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21358 · Cited by 118 · see citing works

Cell surface oxygen consumption by mitochondrial gene knockout cells

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Regulation of specific target genes and biological responses by estrogen receptor subtype agonists

Leitman, D. C., Paruthiyil, S., Vivar, O. I., Saunier, E. F., Herber, C. B., Cohen, I. V., Tagliaferri, M. A., & Speed, T. P. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.09.009 · Cited by 105 · see citing works

Activation of estrogen receptor α increases and estrogen receptor β decreases apolipoprotein E expression in hippocampus in vitro and in vivo

Wang, J. M., Irwin, R. W., & Brinton, R. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608128103 · Cited by 103 · see citing works

Mitochondria and Neurodegeneration

Beal, M. F. (2007) · Novartis Foundation symposium · doi:10.1002/9780470725207.ch13 · Cited by 98 · see citing works

A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo.

Zhao, L.-Q., Mao, Z.-S., & Brinton, R. (2009) · Endocrinology · doi:10.1210/en.2008-0715 · Cited by 96 · see citing works

Estrogen and Mitochondria: A New Paradigm for Vascular Protection?

DUCKLES, S. P. (2006) · Molecular Interventions · doi:10.1124/mi.6.1.6 · Cited by 95 · see citing works

Estrogen induces rapid translocation of estrogen receptor β, but not estrogen receptor α, to the neuronal plasma membrane

Sheldahl, L. C., Shapiro, R. A., Bryant, D. N., Koerner, I. P., & Dorsa, D. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.035 · Cited by 77 · see citing works

Menopausal vasomotor symptoms: a review of causes, effects and evidence-based treatment options.

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Medroxyprogesterone Acetate Antagonizes Estrogen Up-Regulation of Brain Mitochondrial Function

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Nuclear and Extranuclear Estrogen Binding Sites in the Rat Forebrain and Autonomic Medullary Areas

Milner, T. A., Lubbers, L. S., Alves, S. E., & McEwen, B. S. (2008) · Endocrinology · doi:10.1210/en.2008-0307 · Cited by 57 · see citing works

Estrogen Selectively Up-Regulates the Phospholipid Hydroperoxide Glutathione Peroxidase in the Oviducts

Lapointe, J., Kimmins, S., MacLaren, L. A., & Bilodeau, J. (2005) · Endocrinology · doi:10.1210/en.2004-1373 · Cited by 56 · see citing works

Estrogen receptor β-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause

Zhao, L., Mao, Z., Schneider, L. S., & Brinton, R. D. (2011) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3182175b66 · Cited by 40 · see citing works

Estrogen Receptor β: Switching to a New Partner and Escaping from Estrogen

Leung, Y., & Ho, S. (2011) · Science Signaling · doi:10.1126/scisignal.2001991 · Cited by 23 · see citing works

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Major depressive disorder: hypothesis, mechanism, prevention and treatment

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Age, APOE and sex: triad of risk of Alzheimer’s disease.

Riedel, B. C., Thompson, P. M., & Brinton, R. D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.012 · Cited by 627 · see citing works

Mechanisms of sex differences in Alzheimer’s disease

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Effect of Sex Differences on Brain Mitochondrial Function and Its Suppression by Ovariectomy and in Aged Mice

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Platelet bioenergetics correlate with muscle energetics and are altered in older adults

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Assessing Mitochondrial Bioenergetics in Isolated Mitochondria from Mouse Heart Tissues Using Oroboros 2k-Oxygraph

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