Sleep and cognition at baseline and the effects of REM sleep diminution after 1 week of antidepressive treatment in patients with depression
Abstract
It has been hypothesized that non-rapid eye movement (NREM) sleep facilitates declarative memory consolidation, and rapid eye movement (REM) sleep is particularly important in promoting procedural learning. The aim of this study was to examine the effects of pharmacological REM sleep suppression on performance in different neuropsychological tasks. For our baseline, we chose 41 moderately depressed patients (age range 19-44 years), who were not taking antidepressants. In the morning after polysomnography, we tested memory recall and cognitive flexibility by assessment of verbal and figural fluency, a shift of attention task and the Trail Making Test B. After recording baseline values, patients were assigned randomly to one of three treatment groups: medication with citalopram; medication with reboxetine; or exclusive treatment with psychotherapy. Retesting took place 1 week after onset of treatment. The main results were: (1) an association of slow-wave sleep with verbal memory performance at baseline; (2) a suppression of REM sleep in patients taking citalopram and reboxetine; (3) no differences regarding neuropsychological performance within the treatment groups; and (4) no association of REM sleep diminution with decreases in memory performance or cognitive flexibility in patients treated with citalopram or reboxetine. In line with other studies, our results suggest that there are no negative effects of a decrease in REM sleep on memory performance in patients taking antid…
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A systematic clinical study of SSRI citalopram and SNRI reboxetine in moderately depressed patients failed to reveal any association of REM sleep diminution after reuptake inhibitors with decreases in overnight retention of declarative memories (word lists) or procedural skills (mirror tracing).
“Also, a more systematic clinical study of the effects of the SSRI citalopram and the SRNI reboxetine in moderately depressed patients failed to reveal any association of REM sleep diminution after the reuptake inhibitors, with decreases in overnight retention of declarative memories (word lists) or procedural skills (mirror tracing) (466).”
From About Sleep's Role in Memory (2013) · cites this paper as [466]
Cites
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Stickgold, R. (2005) · Nature · doi:10.1038/nature04286 · Cited by 1,857 · see citing works
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Diekelmann, S., Wilhelm, I., & Born, J. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.08.002 · Cited by 566 · cited 14× · see citing works
“Associations of sleep and cognition at baseline There was a significant positive partial correlation (controlled for age) between the duration of SWS at baseline and overnight verbal memory retention (Table 1).”
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Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
- Authors
- GÖDER, R., SEECK-HIRSCHNER, M., STINGELE, K., HUCHZERMEIER, C., KROPP, C., PALASCHEWSKI, M., ALDENHOFF, J., & KOCH, J.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- Corresponding author
- GÖDER, ROBERT
- Venue
- Journal of Sleep Research
- Publisher
- Wiley
- Published
- 2011-02-24
- Volume
- 20
- Issue
- 4
- Pages
- 544-551
- ISSN
- 0962-1105 (ISSN-L)
- OpenAlex
- W1589817293
- Cited by
- 43
- References
- 3
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 3
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Sleep Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- REM sleep suppression, depression, antidepressants, citalopram, reboxetine, cognitive flexibility, verbal memory, slow-wave sleep, procedural learning, memory consolidation, psychotherapy
- MeSH terms
- Reboxetine, Adult, Cognition, Depressive Disorder, Female, Humans, Male, Memory, Morpholines, Neuropsychological Tests, Sleep, Sleep, REM, Citalopram, Polysomnography, Antidepressive Agents, Second-Generation, Young Adult
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