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The arcB gene of Escherichia coli encodes a sensor‐regulator protein for anaerobic repression of the arc modulon
Abstract
Summary: The arcA (dye) and arcB genes of Escherichia coli are responsible for anaerobic repression of target operons and regulons of aerobic function (the arc modulon). The amino acid sequence of ArcA (Dye) indicated that it is the regulator protein of a two‐component control system. Here we show that ArcB is a membrane sensor protein on the basis of its deduced amino acid sequence (778 residues), hydropathicity profile, and cellular distribution. On the carboxyl end of the ArcB sequence there is an additional domain showing homology with conserved regions of regulator proteins. Deletion into this domain destroyed ArcB function. ArcB conserved a histidine residue for autophosphorylation of the sensor proteins, and aspartic residues important for the regulator proteins.
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Cited by
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Chang, C., Kwok, S. F., Bleecker, A. B., & Meyerowitz, E. M. (1993) · Science · doi:10.1126/science.8211181 · Cited by 1,521
Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases
Mascher, T., Helmann, J. D., & Unden, G. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00020-06 · Cited by 721
Quinones as the Redox Signal for the Arc Two-Component System of Bacteria
Georgellis, D., Kwon, O., & Lin, E. C. C. (2001) · Science · doi:10.1126/science.1059361 · Cited by 465
Self-citationThe Histidine Protein Kinase Superfamily
Grebe, T. W., & Stock, J. B. (1999) · Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60167-8 · Cited by 379
Metadata
- Authors
- Iuchi, S., Matsuda, Z., Fujiwara, T., & Lin, E. C. C.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1990-05
- Volume
- 4
- Issue
- 5
- Pages
- 715-727
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2130904512
- Cited by
- 185
- References
- 0
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The arcB gene of Escherichia coli encodes a sensor‐regulator protein for anaerobic repression of the arc modulon. https://app.cochat.ai/papers/10.1111/j.1365-2958.1990.tb00642.x
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- Iuchi, S., Matsuda, Z., Fujiwara, T., & Lin, E. C. C. (1990). The arcB gene of Escherichia coli encodes a sensor‐regulator protein for anaerobic repression of the arc modulon. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1990.tb00642.x
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