The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Selenocysteine: the 21st amino acid
Abstract
Summary: Great excitement was elicited in the field of selenium biochemistry in 1986 by the parallel discoveries that the genes encoding the selenoproteins glutathione peroxidase and bacterial formate dehydrogenase each contain an in‐frame TGA codon within their coding sequence. We now know that this codon directs the incorporation of selenium, in the form of selenocysteine, into these proteins. Working with the bacterial system has led to a rapid increase in our knowledge of selenocysteine biosynthesis and to the exciting discovery that this system can now be regarded as an expansion of the genetic code. The prerequisites for such a definition are co‐translational insertion into the polypeptide chain and the occurrence of a tRNA molecule which carries selenocysteine. Both of these criteria are fulfilled and, moreover, tRNA Sec even has its own special translation factor which delivers it to the translating ribosome. It is the aim of this article to review the events leading to the elucidation of selenocysteine as being the 21st amino acid.
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Cites
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Glutathione peroxidase: A selenoenzyme
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Self-citationGene for a novel tRNA species that accepts L-serine and cotranslationally inserts selenocysteine
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Self-citationCone, J. E., Del Río, R. M., Davis, J. N., & Stadtman, T. C. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.8.2659 · Cited by 311
Effects of surrounding sequence on the suppression of nonsense codons
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Identification of a selenocysteyl-tRNASer in mammalian cells that recognizes the nonsense codon, UGA
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Reich, H. J., & Hondal, R. J. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00031 · Cited by 923
An Expanded Eukaryotic Genetic Code
Chin, J. W., Cropp, T. A., Anderson, J. C., Mukherji, M., Zhang, Z., & Schultz, P. G. (2003) · Science · doi:10.1126/science.1084772 · Cited by 820
Selenium and Selenoproteins: It’s Role in Regulation of Inflammation
Hariharan, S., & Dharmaraj, S. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00690-x · Cited by 659
On the nature of selenium toxicity and carcinostatic activity
Spallholz, J. E. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90007-8 · Cited by 630
Antioxidant Function of Thioredoxin and Glutaredoxin Systems
Holmgren, A. (2000) · Antioxidants & Redox Signaling · doi:10.1089/ars.2000.2.4-811 · Cited by 502
Metadata
- Authors
- Böck, A., Forchhammer, K., Heider, J., Leinfelder, W., Sawers, G., Veprek, B., & Zinoni, F.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1991-03
- Volume
- 5
- Issue
- 3
- Pages
- 515-520
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2168912171
- Cited by
- 686
- References
- 30
- FWCI
- 24.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Böck, A., Forchhammer, K., Heider, J., Leinfelder, W., Sawers, G., Veprek, B., & Zinoni, F. (1991). Selenocysteine: the 21st amino acid. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1991.tb00722.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
