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DNA sequence and analysis of the bet genes encoding the osmoregulatory choline—glycine betaine pathway of Escherichia coli
Abstract
Summary: The sequence was determined of 6493 nucleotides encompassing the bet genes of Escherichia coli which encode the osmoregulatory choline—glycine betaine pathway. Four open reading frames were identified: betA encoding choline dehydrogenase, a flavoprotein of 61.9kDa; betB encoding betaine aldehyde dehydrogenase (52.6kDa); betT encoding a proton‐motive‐force‐driven, high‐affinity transport system for choline (75.8kDa); and betl, capable of encoding a protein of 21.8 kDa, implicated as a repressor involved in choline regulation of the bet genes. Identification of the genes was supported by subcloning, physical mapping of λ plac Mu53 insertions, amino acid sequence similarity, or N‐terminal amino acid sequencing. The bet genes are tightly spaced, with bet T located upstream of, and transcribed divergently to, the tandemly linked betlBA genes.
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Cited by
Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
Craciun, S., & Balskus, E. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215689109 · Cited by 701
The physiology of Campylobacter species and its relevance to their role as foodborne pathogens
Park, S. F. (2002) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(01)00678-x · Cited by 451
Engineering of enhanced glycine betaine synthesis improves drought tolerance in maize
Quan, R., Shang, M., Zhang, H., Zhao, Y., & Zhang, J. (2004) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2004.00093.x · Cited by 358
Mykytczuk, N. C. S., Foote, S. J., Omelon, C. R., Southam, G., Greer, C. W., & Whyte, L. G. (2013) · The ISME Journal · doi:10.1038/ismej.2013.8 · Cited by 329
Compatible Solute Engineering in Plants for Abiotic Stress Tolerance - Role of Glycine Betaine
Hussain Wani, S., Brajendra Singh, N., Haribhushan, A., & Iqbal Mir, J. (2013) · Current Genomics · doi:10.2174/1389202911314030001 · Cited by 296
Metadata
- Authors
- Lamark, T., Kaasen, I., Eshoo, M. W., Falkenberg, P., McDougall, J., & Strøm, A. R.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1991-05
- Volume
- 5
- Issue
- 5
- Pages
- 1049-1064
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2034744313
- Cited by
- 262
- References
- 0
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: DNA sequence and analysis of the bet genes encoding the osmoregulatory choline—glycine betaine pathway of Escherichia coli. https://app.cochat.ai/papers/10.1111/j.1365-2958.1991.tb01877.x
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- Lamark, T., Kaasen, I., Eshoo, M. W., Falkenberg, P., McDougall, J., & Strøm, A. R. (1991). DNA sequence and analysis of the bet genes encoding the osmoregulatory choline—glycine betaine pathway of Escherichia coli. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1991.tb01877.x
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