The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Nitrate regulation of anaerobic respiratory gene expression in Escherichia coli
Abstract
Synthesis of most anaerobic respiratory pathways is subject to dual regulation by anaerobiosis and nitrate. Anaerobic induction is mediated by the FNR protein. Dual interacting two-component regulatory systems mediate nitrate induction and repression. The response regulator protein NARL binds DNA to control nitrate induction and repression of genes encoding nitrate respiration enzymes and alternate anaerobic respiratory enzymes, respectively. The homologous protein NARP controls nitrite induction of at least two operons. Nitrate and nitrite signalling are both mediated by the homologous sensor proteins NARX and NARQ. Recent mutational analyses have defined a heptamer sequence necessary for specific DNA binding by the NARL protein. These heptamers are located at different positions in the control regions of different operons. The NARL protein-binding sites in the narG (nitrate reductase) and narK (nitrate-nitrite antiporter) operon control regions are located approximately 200bp upstream of the transcription initiation site. The integration host factor (IHF) greatly stimulates nitrate induction of these operons, indicating that a specific DNA loop brings NARL protein, bound at the upstream region, into the proximity of the promoter for transcription activation. Other NARL protein-dependent opersons do not require IHF for nitrate induction, and the arrangement of NARL heptamer sequences in these control regions is quite different. This complexity of signal transduction pathways, coupled with the diversity of control region architecture, combine to provide many interesting areas for future investigation. An additional challenge is to determine how or if the FNR and NARL proteins interact to mediate dual positive control of transcription initiation.
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“Comparatively, while the DNRA nitrate reductase, nap, shares some regulatory elements with nar such as the oxygen-dependent FNR[77,256,261–264]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [262]
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Cites
COMMUNICATION MODULES IN BACTERIAL SIGNALING PROTEINS
Parkinson, J. S., & Kofoid, E. (1992) · Annual Review of Genetics · doi:10.1146/annurev.ge.26.120192.000443 · Cited by 1,450
Integration host factor: A protein for all reasons
Friedman, D. I. (1988) · Cell · doi:10.1016/0092-8674(88)90213-9 · Cited by 492
Nitrate respiration in relation to facultative metabolism in enterobacteria
Stewart, V. J. (1988) · Microbiological Reviews · doi:10.1128/mr.52.2.190-232.1988 · Cited by 438
FNR and its role in oxygen-regulated gene expression in Escherichia coli
Spiro, S., & Guest, J. R. (1990) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1990.tb04109.x · Cited by 416
Hoover, T. R., Santero, E., Porter, S. C., & Kustu, S. G. (1990) · Cell · doi:10.1016/0092-8674(90)90284-l · Cited by 359
Rabin, R. S., & Stewart, V. J. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.11.3259-3268.1993 · Cited by 223
RcsA, an unstable positive regulator of capsular polysaccharide synthesis
Stout, V., Torres-Cabassa, A., Maurizi, M. R., Gutnick, D. L., & Gottesman, S. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.5.1738-1747.1991 · Cited by 221
Requirement of Fnr and NarL functions for nitrate reductase expression in Escherichia coli K-12
Stewart, V. J. (1982) · Journal of Bacteriology · doi:10.1128/jb.151.3.1320-1325.1982 · Cited by 177
Role of the RNA polymerase α subunit in transcription activation
Ishihama, A. (1992) · Molecular Microbiology · doi:10.1111/j.1365-2958.1992.tb02196.x · Cited by 175
Stewart, V. J., & Parales, J. V. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.4.1589-1597.1988 · Cited by 170
Cited by
Sorted by citations
Two-Component Signal Transduction
Stock, A., Robinson, V. L., & Goudreau, P. N. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.183 · Cited by 3,653
Merrick, M. J., & Edwards, R. A. (1995) · Microbiological Reviews · doi:10.1128/mr.59.4.604-622.1995 · Cited by 752
Unden, G., & Bongaerts, J. (1997) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(97)00034-0 · Cited by 744
Berks, B. C., Ferguson, S. J., Moir, J. W. B., & Richardson, D. J. (1995) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(95)00092-5 · Cited by 596
DNRA: A short-circuit in biological N-cycling to conserve nitrogen in terrestrial ecosystems
Pandey, C. B., Kumar, U., Kaviraj, M., Minick, K. J., Mishra, A. K., & Singh, J. S. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139710 · Cited by 447
Metadata
- Authors
- Stewart, V.
- Affiliations
- Cornell University (US)
- Corresponding author
- Stewart, Valley
- ORCID
- Stewart, Valley
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1993-08
- Volume
- 9
- Issue
- 3
- Pages
- 425-434
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2099926472
- Cited by
- 176
- References
- 57
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 5
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- nitrate regulation, anaerobic respiration, Escherichia coli, NarL, NARP, NARX network, FNR, two-component systems, nitrate reductase, integration host factor, transcriptional regulation, dual regulation
- MeSH terms
- Nitrate Transporters, Anaerobiosis, Bacterial Proteins, Carrier Proteins, DNA-Binding Proteins, Escherichia coli, Genes, Bacterial, Iron-Sulfur Proteins, Nitrate Reductases, Nitrates, Oxygen Consumption, Gene Expression Regulation, Bacterial, Anion Transport Proteins, Escherichia coli Proteins, Nitrate Reductase
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