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Cited by 243

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The PTR family: a new group of peptide transporters

Open access
Steiner, Henry‐York, Naider, Fred, Becker, Jeffrey M.·1995·Molecular Microbiology

Abstract

Summary: The transport of peptides into cells is a well‐documented biological phenomenon which is accomplished by specific, energy‐dependent transporters found in a number of organisms as diverse as bacteria and humans. Until recently, the majority of peptide transporters cloned and characterized were found to be proteins of the ATP‐binding cassette (ABC) family. We report the identification of a new family of peptide transporters, which we call the PTR family. This group of proteins, distinct from the ABC‐type peptide transporters, was uncovered by sequence analyses of a number of recently discovered peptide transport proteins. Alignment of these proteins demonstrated a high number of identical and similar residues and identified conserved glycosylation and phosphorylation sites, as well as a structural motif unique to this group of proteins. Cluster analysis among the proteins indicated these sequences were indeed related and could be further divided into two subfamilies. A phylogenetic analysis of these new peptide transport sequences, compared to over 50 other peptide and membrane‐bound transporters, showed that these proteins comprise a distinct, separate group of proteins.

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Crossref · 10.1111/j.1365-2958.1995.tb02310.x

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Metadata

Authors
Steiner, H., Naider, F., & Becker, J. M.
Venue
Molecular Microbiology
Publisher
Wiley
Published
1995-06
Volume
16
Issue
5
Pages
825-834
ISSN
  • 0950-382X (ISSN-L)
  • 1365-2958
OpenAlex
W2061110447
Cited by
243
References
4
FWCI
4.42
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The PTR family: a new group of peptide transporters. https://app.cochat.ai/papers/10.1111/j.1365-2958.1995.tb02310.x
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Steiner, H., Naider, F., & Becker, J. M. (1995). The PTR family: a new group of peptide transporters. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1995.tb02310.x

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.