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A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K‐12 chromosome

Mills, Debra M., Bajaj, Vivek, Lee, Catherine A.·1995·Molecular Microbiology

Abstract

Summary: Many Salmonella typhimurium genes are required for bacterial entry into host cells. P22 transduction analysis has localized several invasion loci near minute 59 on the S. typhimurium chromosome. To further characterize the 59–60 min chromosomal region, we determined the physical and genetic map of 85 kb of S. typhimurium DNA between srl and cysC. It was previously shown that some of the invasion genes from this region are not present in Escherichia coli K‐12. We examined whether other S. typhimurium genes on the 85 kb of DNA were similarly absent from E. coli We found that a contiguous 40 kb fragment of the S. typhimurium chromosome which encodes invasion genes is absent from the corresponding region of the E. coli K‐12 chromosome and may represent a pathogenicity island. We speculate that acquisition of the 40 kb region must have significantly advanced the evolution of Salmonella as a pathogen.

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Metadata

Authors
Mills, D. M., Bajaj, V., & Lee, C. A.
Venue
Molecular Microbiology
Publisher
Wiley
Published
1995-02
Volume
15
Issue
4
Pages
749-759
ISSN
  • 0950-382X (ISSN-L)
  • 1365-2958
OpenAlex
W2043623479
Cited by
356
References
0
FWCI
12.17
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K‐12 chromosome. https://app.cochat.ai/papers/10.1111/j.1365-2958.1995.tb02382.x
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Mills, D. M., Bajaj, V., & Lee, C. A. (1995). A 40 kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K‐12 chromosome. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1995.tb02382.x

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