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The regulation of transcription initiation by integration host factor
Abstract
Summary: Integration host factor (IHF) of Escherichia coli is an asymmetric histone‐like protein that binds and bends the DNA at specific sequences. IHF functions as an accessory factor in a wide variety of processes including replication, site‐specific recombination and transcription. In many of these processes IHF was shown to act as an architectural element which helps the formation of nucleo‐protein complexes by bending of the DNA at specific sites. This MicroReview shows how such a structural role of IHF can influence the initiation of transcription. In addition, it summarizes the evidence indicating that IHF can stimulate transcription via a direct interaction with RNA polymerase and explores the possibility that the asymmetry of the IHF protein might reflect such an interaction
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Cited by
Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins
Maddocks, S. E., & Oyston, P. C. F. (2008) · Microbiology · doi:10.1099/mic.0.2008/022772-0 · Cited by 891
Crystal Structure of an IHF-DNA Complex: A Protein-Induced DNA U-Turn
Rice, P. A., Yang, S.-W., Mizuuchi, K., & Nash, H. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81824-3 · Cited by 802
Twelve Species of the Nucleoid-associated Protein from Escherichia coli
Azam, T. A., & Ishihama, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.33105 · Cited by 473
Pratt, L. A., Hsing, W., Gibson, K. E., & Silhavy, T. J. (1996) · Molecular Microbiology · doi:10.1111/j.1365-2958.1996.tb02532.x · Cited by 317
SIMULATION OF PROKARYOTIC GENETIC CIRCUITS
McAdams, H. H., & Arkin, A. (1998) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.27.1.199 · Cited by 273
Metadata
- Authors
- Goosen, N., & van de Putte, P.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1995-04
- Volume
- 16
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2052514587
- Cited by
- 236
- References
- 0
- FWCI
- 11.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goosen, N., & van de Putte, P. (1995). The regulation of transcription initiation by integration host factor. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.1995.tb02386.x
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
