The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
SIMULATION OF PROKARYOTIC GENETIC CIRCUITS
Abstract
▪ Abstract Biochemical and genetic approaches have identified the molecular mechanisms of many genetic reactions, particularly in bacteria. Now a comparably detailed understanding is needed of how groupings of genes and related protein reactions interact to orchestrate cellular functions over the cell cycle, to implement preprogrammed cellular development, or to dynamically change a cell's processes and structures in response to environmental signals. Simulations using realistic, molecular-level models of genetic mechanisms and of signal transduction networks are needed to analyze dynamic behavior of multigene systems, to predict behavior of mutant circuits, and to identify the design principles applicable to design of genetic regulatory circuits. When the underlying design rules for regulatory circuits are understood, it will be far easier to recognize common circuit motifs, to identify functions of individual proteins in regulation, and to redesign circuits for altered functions.
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Cites
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Self-citationRobustness in simple biochemical networks
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Modeling and Simulation of Genetic Regulatory Systems: A Literature Review
de Jong, H. (2002) · Journal of Computational Biology · doi:10.1089/10665270252833208 · Cited by 2,663
Structure and function of the feed-forward loop network motif
Mangan, S., & Alon, U. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2133841100 · Cited by 1,827
Inferring Genetic Networks and Identifying Compound Mode of Action via Expression Profiling
Gardner, T. S., di Bernardo, D., Lorenz, D., & Collins, J. J. (2003) · Science · doi:10.1126/science.1081900 · Cited by 1,117
Synthetic biology: new engineering rules for an emerging discipline
Andrianantoandro, E., Basu, S., Karig, D. K., & Weiss, R. (2006) · Molecular Systems Biology · doi:10.1038/msb4100073 · Cited by 1,081
Genetic circuit design automation
Nielsen, A. A. K., Der, B. S., Shin, J., Vaidyanathan, P., Paralanov, V., Strychalski, E. A., Ross, D., Densmore, D., & Voigt, C. A. (2016) · Science · doi:10.1126/science.aac7341 · Cited by 1,020
Metadata
- Authors
- McAdams, H. H., & Arkin, A.
- Venue
- Annual Review of Biophysics and Biomolecular Structure
- Publisher
- Annual Reviews
- Published
- 1998-06
- Volume
- 27
- Issue
- 1
- Pages
- 199-224
- ISSN
- 1056-8700 (ISSN-L)
- 1545-4266
- OpenAlex
- W2074743596
- Cited by
- 273
- References
- 83
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- McAdams, H. H., & Arkin, A. (1998). SIMULATION OF PROKARYOTIC GENETIC CIRCUITS. Annual Review of Biophysics and Biomolecular Structure. https://doi.org/10.1146/annurev.biophys.27.1.199
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
