The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Redox and antioxidant systems of the malaria parasite Plasmodium falciparum
Abstract
Summary: The malaria parasite Plasmodium falciparum is highly adapted to cope with the oxidative stress to which it is exposed during the erythrocytic stages of its life cycle. This includes the defence against oxidative insults arising from the parasite's metabolism of haemoglobin which results in the formation of reactive oxygen species and the release of toxic ferriprotoporphyrin IX. Central to the parasite's defences are superoxide dismutases and thioredoxin‐dependent peroxidases; however, they lack catalase and glutathione peroxidases. The vital importance of the thioredoxin redox cycle (comprising NADPH, thioredoxin reductase and thioredoxin) is emphasized by the confirmation that thioredoxin reductase is essential for the survival of intraerythrocytic P. falciparum. The parasites also contain a fully functional glutathione redox system and the low‐molecular‐weight thiol glutathione is not only an important intracellular thiol redox buffer but also a cofactor for several redox active enzymes such as glutathione S‐transferase and glutaredoxin. Recent findings have shown that in addition to these cytosolic redox systems the parasite also has an important mitochondrial antioxidant defence system and it is suggested that lipoic acid plays a pivotal part in defending the organelle from oxidative damage.
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Cites
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Structure, mechanism and regulation of peroxiredoxins
Wood, Z. A., Schröder, E., Robin Harris, J., & Poole, L. B. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)00003-8 · Cited by 2,544
Physiological functions of thioredoxin and thioredoxin reductase
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Strategies of antioxidant defense
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Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle
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The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews · doi:10.1111/brv.12140 · Cited by 1,576
Percário, S., Moreira, D., Gomes, B., Ferreira, M., Gonçalves, A., Laurindo, P., Vilhena, T., Dolabela, M., & Green, M. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131216346 · Cited by 363
Metabolic maps and functions of the Plasmodium mitochondrion
van Dooren, G. G., Stimmler, L. M., & McFadden, G. I. (2006) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2006.00027.x · Cited by 271
Metadata
- Authors
- Müller, S.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2004-08-03
- Volume
- 53
- Issue
- 5
- Pages
- 1291-1305
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2160455928
- Cited by
- 310
- References
- 110
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
