The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works

Embryonic Stem Cell Lines Derived from Human Blastocysts

Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947 · see citing works

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works

The Metabolic and Molecular Bases of Inherited Disease

Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101 · see citing works

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works

Escherichia coli and Salmonella :cellular and molecular biology

Neidhardt, F. C. (1996) · ASM Press eBooks · Cited by 8,230 · see citing works

Principles of biochemistry

(1978) · Biochemical Education · doi:10.1016/0307-4412(78)90049-3 · Cited by 5,073 · see citing works

Regulation of cancer cell metabolism

Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744 · see citing works

Lipopolysaccharide endotoxins

Raetz, C. R. H., & Whitfield, C. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135414 · Cited by 4,404 · see citing works

Interplay between Cortical Spreading Depolarization and Seizures

Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,718 · see citing works

An Energy Budget for Signaling in the Grey Matter of the Brain

Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543 · see citing works

Targeting RAS signalling pathways in cancer therapy

Downward, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc969 · Cited by 3,262 · see citing works

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927 · cited 2× · see citing works

Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR

Ardenkjær‐Larsen, J. H., Fridlund, B., Gram, A., Hansson, G., Hansson, L., Lerche, M. H., Servin, R., Thaning, M., & Golman, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1733835100 · Cited by 2,870 · see citing works

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820 · see citing works

Sickle-cell disease

Rees, D. C., Williams, T. N., & Gladwin, M. T. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61029-x · Cited by 2,504 · see citing works

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works

Mitochondria and cancer

Wallace, D. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3365 · Cited by 2,404 · see citing works

Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313 · see citing works

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020 · see citing works

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019 · see citing works

Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity

Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796 · see citing works

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003428107 · Cited by 1,742 · see citing works

Metabolism and functions of glutathione in brain

Dringen, R. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00060-x · Cited by 1,702 · see citing works

Glucose-6-phosphate dehydrogenase deficiency

Cappellini, M., & Fiorelli, G. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60073-2 · Cited by 1,590 · see citing works

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

Pavlides, S., Whitaker-Menezes, D., Castello-Cros, R., Flomenberg, N., Witkiewicz, A. K., Frank, P. G., Casimiro, M. C., Wang, C., Fortina, P., Addya, S., et al. (2009) · Cell Cycle · doi:10.4161/cc.8.23.10238 · Cited by 1,391 · see citing works

THE SHIKIMATE PATHWAY

Herrmann, K. M., & Weaver, L. M. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.473 · Cited by 1,343 · see citing works

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1- 13 C]Pyruvate

Nelson, S. J., Kurhanewicz, J. V., Vigneron, D. B., Larson, P. E. Z., Harzstark, A. L., Ferrone, M., Criekinge, M. V., Chang, J. W., Bok, R., Park, I., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006070 · Cited by 1,289 · see citing works

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

Levine, A. J., & Puzio-Kuter, A. M. (2010) · Science · doi:10.1126/science.1193494 · Cited by 1,243 · see citing works

Mitochondria and neuronal survival

Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243 · see citing works

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Anastasiou, D., Poulogiannis, G., Asara, J. M., Boxer, M. B., Jiang, J., Shen, M., Bellinger, G., Sasaki, A. T., Locasale, J. W., Auld, D. S., et al. (2011) · Science · doi:10.1126/science.1211485 · Cited by 1,196 · see citing works

Glucose-6-phosphate Dehydrogenase

Löhr, G. W., & Waller, H. D. (1974) · Elsevier eBooks · doi:10.1016/b978-0-12-091302-2.50026-8 · Cited by 1,191 · see citing works

Quantitative flux analysis reveals folate-dependent NADPH production

Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., & Rabinowitz, J. D. (2014) · Nature · doi:10.1038/nature13236 · Cited by 1,114 · see citing works

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

Schafer, Z. T., Grassian, A. R., Song, L., Jiang, Z., Gerhart-Hines, Z., Irie, H. Y., Gao, S., Puigserver, P., & Brugge, J. S. (2009) · Nature · doi:10.1038/nature08268 · Cited by 1,031 · see citing works

Brick by brick: metabolism and tumor cell growth

DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.02.003 · Cited by 1,018 · see citing works

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

Folmes, C. D. L., Nelson, T. J., Martinez‐Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y., Pérez-Terzic, C. M., & Terzic, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.011 · Cited by 980 · see citing works

Mitochondria take center stage in aging and neurodegeneration

Beal, M. F. (2005) · Annals of Neurology · doi:10.1002/ana.20624 · Cited by 957 · see citing works

Mitochondria and neuronal activity

Kann, O., & Kovács, R. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00222.2006 · Cited by 847 · see citing works

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1

Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009) · Nature Cell Biology · doi:10.1038/ncb1881 · Cited by 844 · see citing works

The oxidative pentose phosphate pathway: structure and organisation

Kruger, N. J., & von Schaewen, A. (2003) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(03)00039-6 · Cited by 838 · see citing works

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

Wang, J.-B., Erickson, J. W., Fuji, R., Ramachandran, S., Gao, P., Dinavahi, R., Wilson, K. F., Ambrosio, A. L. B., Dias, S. M. G., Dang, C. V., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.08.009 · Cited by 821 · see citing works

Pyruvate kinase type M2 and its role in tumor growth and spreading

Mazurek, S., Boschek, C. B., Hugo, F., & Eigenbrodt, E. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.04.009 · Cited by 812 · see citing works

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

Jiang, P., Du, W., Wang, X., Mancuso, A., Gao, X., Wu, M., & Yang, X. (2011) · Nature Cell Biology · doi:10.1038/ncb2172 · Cited by 798 · see citing works

Towards industrial pentose-fermenting yeast strains

Hahn‐Hägerdal, B., Karhumaa, K., Fonseca, C., Spencer‐Martins, I., & Gorwa‐Grauslund, M. F. (2007) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0827-2 · Cited by 784 · see citing works

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

Hitosugi, T., Kang, S., Vander Heiden, M. G., Chung, T.-W., Elf, S., Lythgoe, K., Dong, S., Lonial, S., Wang, X., Chen, G. Z., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000431 · Cited by 784 · see citing works

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

Yoshida, Y., Takahashi, K., Okita, K., Ichisaka, T., & Yamanaka, S. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.08.001 · Cited by 757 · see citing works

Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis

Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R., & Webb, W. W. (2004) · Science · doi:10.1126/science.1096485 · Cited by 742 · see citing works

Regional aerobic glycolysis in the human brain

Vaishnavi, S. N., Vlassenko, A. G., Rundle, M. M., Snyder, A. Z., Mintun, M. A., & Raichle, M. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010459107 · Cited by 738 · see citing works

The power to reduce: pyridine nucleotides—small molecules with a multitude of functions

Pollak, N., Dölle, C., & Ziegler, M. (2007) · Biochemical Journal · doi:10.1042/bj20061638 · Cited by 730 · see citing works

The global prevalence of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis

Nkhoma, E. T., Poole, C., Vannappagari, V. X., Hall, S. A., & Beutler, E. (2009) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2008.12.005 · Cited by 709 · see citing works

Glucose‐6‐phosphate dehydrogenase, NADPH, and cell survival

Stanton, R. C. (2012) · IUBMB Life · doi:10.1002/iub.1017 · Cited by 706 · see citing works

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research

Kurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia · doi:10.1593/neo.101102 · Cited by 681 · see citing works

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

Yi, W., Clark, P. M., Mason, D. E., Keenan, M. C., Hill, C., Goddard, W. A., Peters, E. C., Driggers, E. M., & Hsieh‐Wilson, L. C. (2012) · Science · doi:10.1126/science.1222278 · Cited by 680 · see citing works

Evolutionary dynamics of carcinogenesis and why targeted therapy does not work

Gillies, R. J., Verduzco, D., & Gatenby, R. A. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3298 · Cited by 677 · see citing works

The genetics of the p53 pathway, apoptosis and cancer therapy

Vázquez, A., Bond, E. E., Levine, A. J., & Bond, G. L. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2656 · Cited by 674 · see citing works

Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts

Varum, S., Rodrigues, A. S., Moura, M. B., Momcilovic, O., Easley, C. A., Ramalho-Santos, J., Van Houten, B., & Schatten, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020914 · Cited by 671 · see citing works

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

Folmes, C. D. L., Dzeja, P. P., Nelson, T. J., & Terzic, A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.10.002 · Cited by 664 · see citing works

Metabolic networks in motion: 13C‐based flux analysis

Sauer, U. (2006) · Molecular Systems Biology · doi:10.1038/msb4100109 · Cited by 664 · see citing works

CNS energy metabolism as related to function

Ames, A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00038-2 · Cited by 663 · see citing works

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Chaneton, B., Hillmann, P., Zheng, L., Martin, A. C. L., Maddocks, O. D. K., Chokkathukalam, A., Coyle, J. E., Jankevics, A., Holding, F. P., Vousden, K. H., et al. (2012) · Nature · doi:10.1038/nature11540 · Cited by 661 · see citing works

Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds

Zhu, S., Li, W., Zhou, H., Wei, W., Ambasudhan, R., Lin, T., Kim, J., Zhang, K., & Ding, S. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.11.015 · Cited by 656 · see citing works

Uncovering transcriptional regulation of metabolism by using metabolic network topology

Patil, K. R., & NIELSEN, J. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406811102 · Cited by 649 · see citing works

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type

Yuneva, M. O., Fan, T. W. M., Allen, T. D., Higashi, R. M., Ferraris, D. V., Tsukamoto, T., Matés, J. M., Alonso, F. J., Wang, C., Seo, Y., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.015 · Cited by 639 · see citing works

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

Heiden, M. G. V., Locasale, J. W., Swanson, K. D., Sharfi, H., Heffron, G. J., Amador‐Noguez, D., Christofk, H. R., Wagner, G., Rabinowitz, J. D., Asara, J. M., et al. (2010) · Science · doi:10.1126/science.1188015 · Cited by 635 · see citing works

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

Haschemi, A., Kosma, P., Gille, L., Evans, C. R., Burant, C. F., Starkl, P., Knapp, B., Haas, R., Schmid, J. A., Jandl, C., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.023 · Cited by 635 · see citing works

Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress

Ralser, M., Wamelink, M. M. C., Kowald, A., Gerisch, B., Heeren, G., Struys, E. A., Klipp, E., Jakobs, C., Breitenbach, M., Lehrach, H. R., et al. (2007) · Journal of Biology · doi:10.1186/jbiol61 · Cited by 627 · see citing works

Astrocyte glycogen and brain energy metabolism

Brown, A. M., & Ransom, B. R. (2007) · Glia · doi:10.1002/glia.20557 · Cited by 626 · see citing works

The Senescence‐Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells

Prigione, A., Fauler, B., Lurz, R., Lehrach, H., & Adjaye, J. (2010) · Stem Cells · doi:10.1002/stem.404 · Cited by 617 · see citing works

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

Rohwer, N., & Cramer, T. (2011) · Drug Resistance Updates · doi:10.1016/j.drup.2011.03.001 · Cited by 608 · see citing works

Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry

Bajad, S. U., Lu, W., Kimball, E., Yuan, J., Peterson, C. N., & Rabinowitz, J. D. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.05.019 · Cited by 593 · see citing works

EXPANDING THE GENETIC CODE

Wang, L., Xie, J., & Schultz, P. G. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.101105.121507 · Cited by 584 · see citing works

Yap1 and Skn7 Control Two Specialized Oxidative Stress Response Regulons in Yeast

Lee, J., Godon, C., Lagniel, G., Spector, D., Garin, J., Labarre, J., & Tolédano, M. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16040 · Cited by 567 · see citing works

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

Lewis, C. A., Parker, S. J., Fiske, B. P., McCloskey, D., Gui, D. Y., Green, C. R., Vokes, N. I., Feist, A. M., Vander Heiden, M. G., & Metallo, C. M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.008 · Cited by 562 · see citing works

Glucose‐6‐phosphate dehydrogenase: a “housekeeping” enzyme subject to tissue‐specific regulation by hormones, nutrients, and oxidant stress

Kletzien, R. F., Harris, P. K. W., & Foellmi, L. A. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.2.8119488 · Cited by 551 · see citing works

Targeted disruption of the housekeeping gene encoding glucose 6‐phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress.

Pandolfi, P. P., Sonati, F., Rivi, R., Mason, P. J., Grosveld, F. G., & Luzzatto, L. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00205.x · Cited by 547 · see citing works

Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo

Marin-Valencia, I., Yang, C., Mashimo, T., Cho, S., Baek, H., Yang, X.-L., Rajagopalan, K. N., Maddie, M., Vemireddy, V., Zhao, Z., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.05.001 · Cited by 529 · see citing works

HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo

Gao, P., Zhang, H., Dinavahi, R., Li, F., Xiang, Y., Raman, V., Bhujwalla, Z. M., Felsher, D. W., Cheng, L., Pevsner, J., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.004 · Cited by 523 · see citing works

Metabolic oxidation regulates embryonic stem cell differentiation

Yanes, Ó., Clark, J., Wong, D. M., Patti, G. J., Sánchez‐Ruiz, A., Benton, H. P., Trauger, S. A., Desponts, C., Ding, S., & Siuzdak, G. E. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.364 · Cited by 506 · see citing works

Metabolomic Analysis via Reversed-Phase Ion-Pairing Liquid Chromatography Coupled to a Stand Alone Orbitrap Mass Spectrometer

Lu, W., Clasquin, M. F., Melamud, E., Amador‐Noguez, D., Caudy, A. A., & Rabinowitz, J. D. (2010) · Analytical Chemistry · doi:10.1021/ac902837x · Cited by 504 · see citing works

Metabolic engineering for improved fermentation of pentoses by yeasts

Jeffries, T. W., & Jin, Y. (2004) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1450-0 · Cited by 501 · see citing works

The Calvin cycle revisited

Raines, C. A. (2003) · Photosynthesis Research · doi:10.1023/a:1022421515027 · Cited by 494 · see citing works

The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex

Lovatt, D., Sonnewald, U., Waagepetersen, H. S., Schousboe, A., He, W., Lin, J. H.-C., Han, X., Takano, T., Wang, S., Sim, F. J., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3404-07.2007 · Cited by 488 · see citing works

Brain lactate metabolism: the discoveries and the controversies

Dienel, G. A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.175 · Cited by 479 · see citing works

The central nervous system in childhood leukemia.II. Subacute leukoencephalopathy

Price, R. A., & Jamieson, P. A. (1975) · Cancer · doi:10.1002/1097-0142(197502)35:2 · Cited by 479 · see citing works

Lipopolysaccharide: Biosynthetic pathway and structure modification

Wang, X., & Quinn, P. J. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.06.002 · Cited by 472 · see citing works

Predicting selective drug targets in cancer through metabolic networks

Folger, O., Jerby‐Arnon, L., Frezza, C., Gottlieb, E., Ruppin, E., & Shlomi, T. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.35 · Cited by 469 · see citing works

Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal

Zhang, J., Nuebel, E., Daley, G. Q., Koehler, C. M., & Teitell, M. A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.10.005 · Cited by 465 · see citing works

Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography–mass spectrometry

Luo, B., Groenke, K., Takors, R., Wandrey, C., & Oldiges, M. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.02.034 · Cited by 461 · see citing works

Aerobic glycolysis in the human brain is associated with development and neotenous gene expression

Goyal, M. S., Hawrylycz, M., Miller, J. A., Snyder, A. Z., & Raichle, M. E. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.020 · Cited by 459 · see citing works

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

Zala, D., Hinckelmann, M.-V., Yu, H., da Cunha, M. M. L., Liot, G., Cordelières, F. P., Marco, S., & Saudou, F. (2013) · Cell · doi:10.1016/j.cell.2012.12.029 · Cited by 459 · see citing works

A method for the determination of changes of glycolytic metabolites in yeast on a subsecond time scale using extraction at neutral pH

Koning, W. J. D., & DAM, K. V. (1992) · Analytical Biochemistry · doi:10.1016/0003-2697(92)90149-2 · Cited by 457 · see citing works

ATM activates the pentose phosphate pathway promoting anti‐oxidant defence and DNA repair

Cosentino, C., Grieco, D., & Costanzo, V. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.330 · Cited by 436 · see citing works

Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain

Bittar, P. G., Charnay, Y., Pellerin, L., Bouras, C., & Magistretti, P. J. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199611000-00001 · Cited by 423 · see citing works

Life on the inside: the intracellular lifestyle of cytosolic bacteria

Ray, K., Marteyn, B., Sansonetti, P. J., & Tang, C. M. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2112 · Cited by 423 · see citing works

Different Responses of Astrocytes and Neurons to Nitric Oxide: The Role of Glycolytically Generated ATP in Astrocyte Protection

Almeida, A., Almeida, J., Bolaños, J. P., & Moncada, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261560998 · Cited by 423 · see citing works

Cytosolic NADP+-dependent isocitrate dehydrogenase status modulates oxidative damage to cells

Lee, S. M., Koh, H., Park, D., Song, B. J., Huh, T., & Park, J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00815-8 · Cited by 422 · see citing works

Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues

Hue, L., & Rider, M. H. (1987) · Biochemical Journal · doi:10.1042/bj2450313 · Cited by 421 · see citing works

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate

Riganti, C., Gazzano, E., Polimeni, M., Aldieri, E., & Ghigo, D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.006 · Cited by 408 · see citing works

Streptomyces in Nature and Medicine

Hopwood, D. A. (2007) · doi:10.1093/oso/9780195150667.001.0001 · Cited by 406 · see citing works

Synthetic non-oxidative glycolysis enables complete carbon conservation

Bogorad, I. W., Lin, T., & Liao, J. C. (2013) · Nature · doi:10.1038/nature12575 · Cited by 403 · see citing works

Carbon metabolism of intracellular bacterial pathogens and possible links to virulence

Eisenreich, W., Dandekar, T., Heesemann, J., & Goebel, W. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2351 · Cited by 397 · see citing works

The Use of C14O2 Yields from Glucose-1- and -6-C14 for the Evaluation of the Pathways of Glucose Metabolism

Katz, J. J., & Wood, H. G. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81292-3 · Cited by 375 · see citing works

Biosynthesis of isoprenoids (carotenoids, sterols, prenyl side-chains of chlorophylls and plastoquinone) via a novel pyruvate/glyceraldehyde 3-phosphate non-mevalonate pathway in the green alga <i>Scenedesmus obliquus</i>

SCHWENDER, J., SEEMANN, M., LICHTENTHALER, H. K., & ROHMER, M. (1996) · Biochemical Journal · doi:10.1042/bj3160073 · Cited by 370 · see citing works

Mitochondrial Regulation in Pluripotent Stem Cells

Xu, X., Duan, S., Yi, F., Ocampo, A., Liu, G., & Belmonte, J. C. I. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.005 · Cited by 370 · see citing works

Three‐dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution.

Lindqvist, Y., Schneider, G., Ermler, U., et al. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05301.x · Cited by 368 · see citing works

Multimolecular Forms of Pyruvate Kinase from Rat and Other Mammalian Tissues*

Imamura, K., & Tanaka, T. (1972) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a129852 · Cited by 364 · see citing works

Perfection in enzyme catalysis: the energetics of triosephosphate isomerase

Knowles, J. R., & Albery, W. J. (1977) · Accounts of Chemical Research · doi:10.1021/ar50112a001 · Cited by 364 · see citing works

Glycolysis: a bioenergetic or a survival pathway?

Bolaños, J. P., Almeida, Á., & Moncada, S. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.10.006 · Cited by 359 · see citing works

Mitochondria in Neurodegeneration: Acute Ischemia and Chronic Neurodegenerative Diseases

Fiskum, G. M., Murphy, A. N., & Beal, M. F. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199904000-00001 · Cited by 351 · see citing works

Ultrahigh Performance Liquid Chromatography−Tandem Mass Spectrometry Method for Fast and Robust Quantification of Anionic and Aromatic Metabolites

Buescher, J. M., Moco, S., Sauer, U., & Zamboni, N. (2010) · Analytical Chemistry · doi:10.1021/ac100101d · Cited by 341 · see citing works

The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: A review

Wamelink, M. M. C., Struys, E. A., & Jakobs, C. (2008) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-008-1015-6 · Cited by 330 · see citing works

Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae

Shenton, D., & Grant, C. M. (2003) · Biochemical Journal · doi:10.1042/bj20030414 · Cited by 326 · see citing works

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

Ditch, S., & Paull, T. T. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.10.002 · Cited by 325 · see citing works

Carbohydrate Metabolism in Archaea: Current Insights into Unusual Enzymes and Pathways and Their Regulation

Bräsen, C., Esser, D., Rauch, B., & Siebers, B. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00041-13 · Cited by 321 · see citing works

Tolerance to furfural-induced stress is associated with pentose phosphate pathway genes ZWF1, GND1, RPE1, and TKL1 in Saccharomyces cerevisiae

Gorsich, S. W., Dien, B. S., Nichols, N. N., et al. (2005) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-005-0142-3 · Cited by 321 · see citing works

Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress#

Wang, Y., Zhou, L., Zhao, Y., Wang, S., Chen, L.-L., Liu, L., Ling, Z., Hu, F., Sun, Y.-P., Zhang, J., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201387224 · Cited by 320 · see citing works

A High Proliferation Rate Is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity

Ruiz, S., Panopoulos, A. D., Herrerias, A., Bissig, K., Lutz, M. K., Berggren, W. T., Verma, I. M., & Belmonte, J. C. I. (2010) · Current Biology · doi:10.1016/j.cub.2010.11.049 · Cited by 317 · see citing works

Microbial Metabolomics with Gas Chromatography/Mass Spectrometry

Koek, M. M., Muilwijk, B., WERF, M. J. V. D., & Hankemeier, T. (2006) · Analytical Chemistry · doi:10.1021/ac051683+ · Cited by 316 · see citing works

Redox and antioxidant systems of the malaria parasite Plasmodium falciparum

Müller, S. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04257.x · Cited by 307 · see citing works

Metabolic Pathway Alterations that Support Cell ProliferationPreprint

Heiden, M. G. V., Lunt, S. Y., Dayton, T. L., Fiske, B. P., Israelsen, W. J., Mattaini, K. R., Vokes, N. I., Stephanopoulos, G. N., Cantley, L. C., Metallo, C. M., et al. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2012.76.010900 · Cited by 300 · see citing works

Energy metabolism in mammalian brain during development

Erecińska, M., Cherian, S., & Silver, I. A. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.003 · Cited by 299 · see citing works

Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia <i>in vitro</i> and on glucose utilization by brain <i>in vivo</i>

Itoh, Y., Esaki, T., Shimoji, K., Cook, M., Law, M. J., Kaufman, E., & Sokoloff, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831078100 · Cited by 297 · see citing works

Insights into the evolution of Archaea and eukaryotic protein modifier systems revealed by the genome of a novel archaeal group

Nunoura, T., Takaki, Y., Kakuta, J., Nishi, S., Sugahara, J., Kazama, H., Chee, G.-J., Hattori, M., Kanai, A., Atomi, H., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1228 · Cited by 291 · see citing works

Coming Full Circle—From Endless Complexity to Simplicity and Back Again

Weinberg, R. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.004 · Cited by 290 · see citing works

Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency

Draper, N., Walker, E. A., Bujalska, I. J., Tomlinson, J. W., Chalder, S. M., Arlt, W., Lavery, G. G., Bedendo, O., Ray, D. W., Laing, I., et al. (2003) · Nature Genetics · doi:10.1038/ng1214 · Cited by 285 · see citing works

A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities

Ronchi, J. A., Figueira, T. R., Ravagnani, F. G., Oliveira, H. C. F., Vercesi, A. E., & Castilho, R. F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.049 · Cited by 283 · see citing works

Cancer metabolism: The Warburg effect today

Ferreira, L. M. R. (2010) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2010.08.006 · Cited by 281 · see citing works

Metabolome in progression to Alzheimer's disease

Orešič, M., Hyötyläinen, T., Herukka, S.-K., Sysi‐Aho, M., Mattila, I. M., Seppänan-Laakso, T., Julkunen, V., Gopalacharyulu, P. V., Hallikainen, M., Koikkalainen, J. R., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.55 · Cited by 280 · see citing works

Global Network Reorganization During Dynamic Adaptations of Bacillus subtilis Metabolism

Buescher, J. M., Liebermeister, W., Jules, M., Uhr, M., Muntel, J., Botella, E., Heßling, B., Kleijn, R. J., Chat, L. L., Lecointe, F., et al. (2012) · Science · doi:10.1126/science.1206871 · Cited by 277 · see citing works

Role of Transcriptional Regulation in Controlling Fluxes in Central Carbon Metabolism of Saccharomyces cerevisiae

Daran-Lapujade, P. A. S., Jansen, M. L. A., Daran, J.-M. G., van Gulik, W. M., de Winde, J. H., & Pronk, J. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309578200 · Cited by 274 · see citing works

Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose

Rodrigues, T. B., Serrão, E. M., Kennedy, B. W. C., Hu, D., Kettunen, M. I., & Brindle, K. M. (2013) · Nature Medicine · doi:10.1038/nm.3416 · Cited by 274 · see citing works

Role of Helicobacter pylori in the Pathogenesis of Gastritis, Peptic Ulcer and Gastric Cancer

Sipponen, P., & Hyvärinen, H. (1993) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529309098333 · Cited by 271 · see citing works

Glucose-6-phosphate dehydrogenase deficiency and malaria

Ruwende, C., & Hill, A. V. S. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050253 · Cited by 270 · see citing works

Streptomyces in nature and medicine: the antibiotic makers

(2008) · Choice Reviews Online · doi:10.5860/choice.45-3774 · Cited by 270 · see citing works

Principles of transcriptional control in the metabolic network of Saccharomyces cerevisiae

Ihmels, J., Levy, R., & Barkai, N. (2003) · Nature Biotechnology · doi:10.1038/nbt918 · Cited by 265 · see citing works

The Regulation of Glucose Metabolism by HIF-1 Mediates a Neuroprotective Response to Amyloid Beta Peptide

Soucek, T., Cumming, R., Dargusch, R., Maher, P., & Schubert, D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00367-2 · Cited by 258 · see citing works

Properties and functions of the thiamin diphosphate dependent enzyme transketolase

Schenk, G., Duggleby, R. G., & Nixon, P. F. (1998) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(98)00095-8 · Cited by 257 · see citing works

Downregulation of Multiple Stress Defense Mechanisms During Differentiation of Human Embryonic Stem Cells

Saretzki, G. C., Walter, T., Atkinson, S. P., Passos, J. F., Bareth, B., Keith, W. N., Stewart, R., Hoare, S. F., Stojković, M., Armstrong, L., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0628 · Cited by 255 · see citing works

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

Bluemlein, K., Grüning, N., Feichtinger, R. G., Lehrach, H. R., Kofler, B., & Ralser, M. (2011) · Oncotarget · doi:10.18632/oncotarget.278 · Cited by 254 · see citing works

HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1–3 and PKM2

Prigione, A., Rohwer, N., Hoffmann, S., Mlody, B., Drews, K., Bukowiecki, R., Blümlein, K., Wanker, E. E., Ralser, M., Cramer, T., et al. (2013) · Stem Cells · doi:10.1002/stem.1552 · Cited by 252 · see citing works

Tumor imaging using hyperpolarized 13 C magnetic resonance spectroscopy

Brindle, K. M., Bohndiek, S. E., Gallagher, F. A., & Kettunen, M. I. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22999 · Cited by 252 · see citing works

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Yamamoto, T., Takano, N., Ishiwata, K., Ohmura, M., Nagahata, Y., Matsuura, T., Kamata, A., Sakamoto, K., Nakanishi, T., Kubo, A., et al. (2014) · Nature Communications · doi:10.1038/ncomms4480 · Cited by 250 · see citing works

Antioxidant and bioenergetic coupling between neurons and astrocytes

Fernandez-Fernandez, S., Almeida, A., & Bolaños, J. P. (2012) · Biochemical Journal · doi:10.1042/bj20111943 · Cited by 247 · see citing works

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

Cheung, E. C., Ludwig, R. L., & Vousden, K. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206530109 · Cited by 244 · see citing works

Non-Enzymatic Glycolysis and Pentose Phosphate Pathway-Like Reactions in a Plausible Archean Ocean

Keller, M. A., Turchyn, A. V., & Ralser, M. (2014) · Molecular Systems Biology · doi:10.1002/msb.20145228 · Cited by 242 · see citing works

TAp73 enhances the pentose phosphate pathway and supports cell proliferation

Du, W., Jiang, P., Mancuso, A., Stonestrom, A. J., Brewer, M. D., Minn, A. J., Mak, T. W., Wu, M., & Yang, X. (2013) · Nature Cell Biology · doi:10.1038/ncb2789 · Cited by 234 · see citing works

SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions

Keller, K. E., Tan, I. S., & Lee, Y.-S. (2012) · Science · doi:10.1126/science.1224409 · Cited by 228 · see citing works

THE ENZYMATIC CONVERSION OF 6-PHOSPHOGLUCONATE TO RIBULOSE-5-PHOSPHATE AND RIBOSE-5-PHOSPHATE

Horecker, B. L., Smyrniotis, P. Z., & Seegmiller, J. E. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52464-4 · Cited by 228 · see citing works

Metabolic reconfiguration is a regulated response to oxidative stress

Grant, C. M. (2008) · Journal of Biology · doi:10.1186/jbiol63 · Cited by 225 · see citing works

Identification of the Mitochondrial NAD+ Transporter in Saccharomyces cerevisiae

Todisco, S., Agrimi, G., Castegna, A., & Palmieri, F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510425200 · Cited by 223 · see citing works

Cancer Cell MetabolismPreprint

Cairns, R. A., Harris, I. S., McCracken, S. A., & Mak, T. W. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.012856 · Cited by 223 · see citing works

Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress

Juhnke, H., Krems, B., Kötter, P., & Entian, K. (1996) · Molecular and General Genetics MGG · doi:10.1007/bf02173011 · Cited by 219 · see citing works

The Yeast Copper/Zinc Superoxide Dismutase and the Pentose Phosphate Pathway Play Overlapping Roles in Oxidative Stress Protection

Slekar, K. H., Kosman, D. J., & Culotta, V. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.28831 · Cited by 216 · see citing works

Pyruvate Kinase Triggers a Metabolic Feedback Loop that Controls Redox Metabolism in Respiring Cells

Grüning, N., Rinnerthaler, M., Bluemlein, K., Mülleder, M., Wamelink, M. M. C., Lehrach, H., Jakobs, C., Breitenbach, M., & Ralser, M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.017 · Cited by 215 · see citing works

PURIFICATION AND PROPERTIES OF d-GLUCOSE-6-PHOSPHATE DEHYDROGENASE

Glaser, L., & Brown, D. H. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52284-0 · Cited by 213 · see citing works

Pathogenesis of Helicobacter pylori Infection

Basso, D., Plebani, M., & Kusters, J. G. (2010) · Helicobacter · doi:10.1111/j.1523-5378.2010.00781.x · Cited by 212 · see citing works

Opportunities and challenges of pluripotent stem cell neurodegenerative disease models

Sandoe, J., & Eggan, K. (2013) · Nature Neuroscience · doi:10.1038/nn.3425 · Cited by 209 · see citing works

Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to Pluripotency

Mathieu, J., Zhou, W., Xing, Y., Sperber, H., Ferreccio, A., Agoston, Z., Kuppusamy, K. T., Moon, R. T., & Ruohola‐Baker, H. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.02.012 · Cited by 209 · see citing works

Revisiting the host as a growth medium

Brown, S. A., Palmer, K. L., & Whiteley, M. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1955 · Cited by 208 · see citing works

Adult-derived neural precursors transplanted into multiple regions in the adult brain

Herrera, D. G., García‐Verdugo, J. M., & Álvarez-Buylla, A. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199912)46:6 · Cited by 204 · see citing works

Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase

Perl, A., Hanczko, R., Caza, T. N., Oaks, Z., & LANDAS, S. K. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.01.014 · Cited by 202 · see citing works

Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth

Liu, H., Huang, D., McArthur, D. L., Boros, L. G., Nissen, N., & Heaney, A. P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4615 · Cited by 201 · see citing works

Glutathione Levels and Sensitivity to Apoptosis Are Regulated by Changes in Transaldolase Expression

Bánki, K., Hutter, E., Colombo, E., Gonchoroff, N. J., & Perl, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32994 · Cited by 200 · see citing works

The Pentose Phosphate Pathway

Horecker, B. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.x200007200 · Cited by 199 · see citing works

Functional Metabolic Screen Identifies 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 as an Important Regulator of Prostate Cancer Cell Survival

R�os, S., Santos, C. R., Moco, S., Baenke, F., Kelly, G. P., Howell, M. T., Zamboni, N., & Schulze, A. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0234 · Cited by 198 · see citing works

NAD Kinase Levels Control the NADPH Concentration in Human Cells

Pollak, N., Niere, M., & Ziegler, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704442200 · Cited by 197 · see citing works

Hereditary Hemolytic Anemia with Triosephosphate Isomerase Deficiency

Schneider, A. S., Valentine, W. N., Hattori, M., et al. (1965) · New England Journal of Medicine · doi:10.1056/nejm196502042720503 · Cited by 195 · see citing works

Isolation and characterization of the ZWF1 gene of Saccharomyces cerevisiae, encoding glucose-6-phosphate dehydrogenase

Nogae, I., & Johnston, M. (1990) · Gene · doi:10.1016/0378-1119(90)90248-p · Cited by 194 · see citing works

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

Cheung, E. C., Athineos, D., Lee, P., Ridgway, R. A., Lambie, W., Nixon, C., Strathdee, D., Blyth, K., Sansom, O. J., & Vousden, K. H. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.05.001 · Cited by 191 · see citing works

Assessment of the Role of the Glutathione and Pentose Phosphate Pathways in the Protection of Primary Cerebrocortical Cultures from Oxidative Stress

Ben‐Yoseph, O., Boxer, P. A., & Ross, B. D. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062329.x · Cited by 189 · see citing works

Metabolic flux distributions in Penicillium chrysogenum during fed‐batch cultivations

Jørgensen, H., NIELSEN, J. K., Villadsen, J., et al. (1995) · Biotechnology and Bioengineering · doi:10.1002/bit.260460205 · Cited by 186 · see citing works

Host Defense Pathways: Role of Redundancy and Compensation in Infectious Disease Phenotypes

Nish, S. A., & Medzhitov, R. M. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.009 · Cited by 186 · see citing works

Reduced Oxidative Pentose Phosphate Pathway Flux in Recombinant Xylose-Utilizing Saccharomyces cerevisiae Strains Improves the Ethanol Yield from Xylose

Jeppsson, M., Johansson, B., Hahn‐Hägerdal, B., & Gorwa‐Grauslund, M. F. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.4.1604-1609.2002 · Cited by 186 · see citing works

Computational epigenetics

Bock, C., & Lengauer, T. (2008) · Bioinform. · doi:10.1093/bioinformatics/btm546 · Cited by 184 · see citing works

Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose

Lee, W. P., Boros, L. G., Puigjaner, J., Bassilian, S., Lim, S. K., & Cascante, M. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.5.e843 · Cited by 183 · see citing works

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

Morgan, H. P., O’Reilly, F. J., Wear, M. A., O’Neill, J. R., Fothergill‐Gilmore, L. A., Hupp, T. R., & Walkinshaw, M. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217157110 · Cited by 182 · see citing works

Hereditary hemolytic anemia with triosephosphate isomerase deficiency

Valentine, W. N., Schneider, A. S., Baughan, M. A., et al. (1966) · The American Journal of Medicine · doi:10.1016/0002-9343(66)90004-0 · Cited by 182 · see citing works

Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress

Filosa, S., Fico, A., Paglialunga, F., Balestrieri, M., Crooke, A., Verde, P., Abrescia, P., Bautista, J. M., & Martini, G. (2003) · Biochemical Journal · doi:10.1042/bj20021614 · Cited by 181 · see citing works

The Pentose Phosphate Pathway Is a Metabolic Redox Sensor and Regulates Transcription During the Antioxidant Response

Krüger, A., Grüning, N., Wamelink, M. M. C., Kerick, M., Kirpy, A., Parkhomchuk, D., Bluemlein, K., Schweiger, M. R., Soldatov, A. V., Lehrach, H. R., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3797 · Cited by 181 · see citing works

CRYSTALLINE TRANSKETOLASE FROM BAKERS' YEAST: ISOLATION AND PROPERTIES

Haba, G. D. L., Leder, I. G., & Racker, E. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70978-2 · Cited by 180 · see citing works

Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming

Zhao, F., Mancuso, A., Bui, T. V., Tong, X., Gruber, J. J., Swider, C. R., Sanchez, P. V., Lum, J. J., Sayed, N., Melo, J. V., et al. (2010) · Oncogene · doi:10.1038/onc.2010.67 · Cited by 179 · see citing works

Helicobacter pylori causes DNA damage in gastric epithelial cells

Obst, B., Wagner, S., Sewing, K. ‐., et al. (2000) · Carcinogenesis · doi:10.1093/carcin/21.6.1111 · Cited by 179 · see citing works

NADP+‐malate dehydrogenase in C3‐plants: Regulation and role of a light‐activated enzyme

Scheibe, R. (1987) · Physiologia Plantarum · doi:10.1111/j.1399-3054.1987.tb04362.x · Cited by 179 · see citing works

Inborn defects in the antioxidant systems of human red blood cells

van Zwieten, R., Verhoeven, A. J., & Roos, D. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.11.022 · Cited by 179 · see citing works

Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network

Chechik, G., Oh, E., Rando, O. J., Weissman, J. S., Regev, A., & Koller, D. (2008) · Nature Biotechnology · doi:10.1038/nbt.1499 · Cited by 176 · see citing works

Hereditary Hemolytic Anemia Associated with Glucosephosphate Isomerase (GPI) Deficiency— a New Enzyme Defect of Human Erythrocytes

Baughan, M. A., Valentine, W. N., Paglia, D. E., et al. (1968) · Blood · doi:10.1182/blood.v32.2.236.236 · Cited by 175 · see citing works

Evolution of energy metabolism and its compartmentation in Kinetoplastida

Hannaert, V., Bringaud, F., Opperdoes, F. R., & Michels, P. A. M. (2003) · Kinetoplastid Biology and Disease · doi:10.1186/1475-9292-2-11 · Cited by 174 · see citing works

Loss of Complex I due to Mitochondrial DNA Mutations in Renal Oncocytoma

Mayr, J. A., Meierhofer, D., Zimmermann, F., Feichtinger, R. G., Kögler, C., Ratschek, M., Schmeller, N. T., Sperl, W., & Kofler, B. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4131 · Cited by 174 · see citing works

Substrate Utilization and Brain Development

Cremer, J. E. (1982) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1982.45 · Cited by 173 · see citing works

Escherichia coli physiology and metabolism dictates adaptation to diverse host microenvironments

Alteri, C. J., & Mobley, H. L. T. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.12.004 · Cited by 172 · see citing works

Oxidation of phosphohexonate and pentose phosphoric acids by yeast enzymes

Dickens, F. (1938) · Biochemical Journal · doi:10.1042/bj0321626 · Cited by 166 · see citing works

Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis

Wanka, C., Steinbach, J., & Rieger, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.384578 · Cited by 165 · see citing works

Peroxynitrite Protects Neurons against Nitric Oxide-mediated Apoptosis

Garcı́a-Nogales, P., Almeida, Á., & Bolaños, J. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206835200 · Cited by 165 · see citing works

Experimental and in Silico Analyses of Glycolytic Flux Control in Bloodstream Form Trypanosoma brucei

Albert, M., Haanstra, J. R., Hannaert, V., Roy, J. V., Opperdoes, F. R., Bakker, B. M., & Michels, P. A. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502403200 · Cited by 163 · see citing works

Oxygen and Ion Concentrations in Normoxic and Hypoxic Brain Cells

Silver, I. A., & Erecińska, M. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4863-8_2 · Cited by 161 · see citing works

Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity

Fendt, S., Buescher, J. M., Rudroff, F., Picotti, P., Zamboni, N., & Sauer, U. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.11 · Cited by 159 · see citing works

Fundamentals of Cancer Metabolism

DeBerardinis, R. J., & Chandel, N. S. (2016) · Science Advances · doi:10.1126/sciadv.1600200 · Cited by 3,013 · see citing works

13 reasons why the brain is susceptible to oxidative stress

Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215 · see citing works

Serine and one-carbon metabolism in cancer

Yang, M., & Vousden, K. H. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.81 · Cited by 992 · see citing works

Metabolism Characteristics of Lactic Acid Bacteria and the Expanding Applications in Food Industry

Wang, Y., Wu, J., Lv, M., Shao, Z., Hungwe, M., Wang, J., Bai, X., Xie, J., Wang, Y., & Geng, W. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.612285 · Cited by 1,001 · see citing works

The metabolic landscape of RAS-driven cancers from biology to therapy

Mukhopadhyay, S., Vander Heiden, M. G., & McCormick, F. (2021) · Nature Cancer · doi:10.1038/s43018-021-00184-x · Cited by 315 · see citing works

Nonenzymatic Metabolic Reactions and Life’s Origins

Muchowska, K. B., Varma, S. J., & Moran, J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00191 · Cited by 317 · see citing works

Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism

Olin-Sandoval, V., Yu, J. S. L., Miller-Fleming, L., Alam, M. T., Kamrad, S., Correia-Melo, C., Haas, R., Segal, J., Peña Navarro, D. A., Herrera-Dominguez, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1442-6 · Cited by 163 · see citing works

An appeal to magic? The discovery of a non-enzymatic metabolism and its role in the origins of life

Ralser, M. (2018) · Biochemical Journal · doi:10.1042/bcj20160866 · Cited by 117 · see citing works

Conditional Iron and pH-Dependent Activity of a Non-Enzymatic Glycolysis and Pentose Phosphate Pathway

Keller, M. A., Zylstra, A., Castro, C., Turchyn, A. V., Griffin, J. L., & Ralser, M. (2016) · Science Advances · doi:10.1126/sciadv.1501235 · Cited by 106 · see citing works

Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma

Inman, D. M., & Harun-Or-Rashid, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00146 · Cited by 88 · see citing works

Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle

Petit, J.-M., & Magistretti, P. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.007 · Cited by 92 · see citing works

A Proteomic Landscape of Candida albicans in the Stepwise Evolution to Fluconazole Resistance

Song, N., Zhou, X., Li, D., Li, X., & Liu, W. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02105-21 · Cited by 17 · see citing works

Proliferating Astrocytes in Primary Culture Do Not Depend upon Mitochondrial Respiratory Complex I Activity or Oxidative Phosphorylation

Silva, E. A., Dalla Costa, A. P., Ruas, J. S., Siqueira-Santos, E. S., Francisco, A., & Castilho, R. F. (2023) · Cells · doi:10.3390/cells12050683 · Cited by 5 · see citing works

Dual metabolic targeting liposomes potentiate triple-negative breast cancer radiosensitivity via glucose and glutathione starvation

Zhang, H., Liu, Y., Gao, X., Ji, G., Zheng, Y., Luo, F., Qi, X., Zhao, S., Guan, S., Wang, C., et al. (2025) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2025.102870 · Cited by 3 · see citing works

Ribose Intervention in the Cardiac Pentose Phosphate Pathway Is Not Species-Specific

Zimmer, H., Ibel, H., Suchner, U., et al. (1984) · Science · doi:10.1126/science.6420889 · Cited by 58 · see citing works

Enzymatic Synthesis of [5-14C]Ribose

Ogbunude, P. O. J. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5196 · Cited by 1 · see citing works

Pentose phosphate metabolism in Leishmania mexicana

Maugeri, D., Cazzulo, J. J., Burchmore, R., et al. (2003) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(03)00173-7 · Cited by 80 · see citing works

An alternative pathway of glucose oxidation: the pentose phosphate pathway

Papachristodoulou, D., Snape, A. M., Elliott, W. H., et al. (2018) · Biochemistry and Molecular Biology · doi:10.1093/hesc/9780198768111.003.0018

Recycling of carbon in the oxidative pentose phosphate pathway in non-photosynthetic plastids

Hartwell, J., Bowsher, C., & Emes, M. J. (1996) · Planta · doi:10.1007/bf00196656 · Cited by 21 · see citing works