The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A novel two‐component system controls the expression of Pseudomonas aeruginosa fimbrial cup genes
Open accessAbstract
Summary: Biofilm formation by the opportunistic pathogen Pseudomonas aeruginosa requires the expression of a number of surface adhesive components. The expression of surface organelles facilitating biofilm formation is controlled by environmental signals acting through transcriptional regulatory networks. We analysed the expression of a family of P. aeruginosa adhesins encoded by three distinct fimbrial gene clusters (cupA, cupB and cupC). Using transposon mutagenesis, we have identified several regulatory loci that upregulated cupB and cupC transcription. One such locus contains three components, RocS1, RocR and RocA1, which represent a variant of a classical two‐component signal transduction pathway. RocS1 is a sensor kinase, RocA1 is a DNA binding response regulator that activates cup genes, and RocR is an antagonist of RocA1 activity. Using a two‐hybrid assay, we have shown that RocS1 interacts with receiver domains of both RocA1 and RocR. Expression of the Cup system in response to environmental stimuli is accomplished by a novel mechanism in which the sensor kinase activates its cognate response regulator through a phosphorelay pathway, while an additional repressor protein modulates this interaction.
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Cites
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
Drenkard, E., & Ausubel, F. M. (2002) · Nature · doi:10.1038/416740a · Cited by 997
Cited by
Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants
Klausen, M., Heydorn, A., Ragas, P., Lambertsen, L., Aaes‐Jørgensen, A., Molin, S., & Tolker‐Nielsen, T. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03525.x · Cited by 1,020
Bacterial community assembly based on functional genes rather than species
Burke, C., Steinberg, P., Rusch, D., Kjelleberg, S., & Thomas, T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101591108 · Cited by 852
Valentini, M., & Filloux, A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.711507 · Cited by 668
Self-citationBarraud, N., Schleheck, D., Klebensberger, J., Webb, J. S., Hassett, D. J., Rice, S. A., & Kjelleberg, S. (2009) · Journal of Bacteriology · doi:10.1128/jb.00975-09 · Cited by 513
Cyclic di-AMP: another second messenger enters the fray
Corrigan, R. M., & Gründling, A. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3069 · Cited by 375
Metadata
- Authors
- Kulasekara, H. D., Ventre, I., Kulasekara, B. R., Lazdunski, A., Filloux, A., & Lory, S.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2004-11-25
- Volume
- 55
- Issue
- 2
- Pages
- 368-380
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2036632982
- Cited by
- 303
- References
- 2
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kulasekara, H. D., Ventre, I., Kulasekara, B. R., Lazdunski, A., Filloux, A., & Lory, S. (2005). A novel two‐component system controls the expression of Pseudomonas aeruginosa fimbrial cup genes. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2004.04402.x
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