The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Bistability in the Bacillus subtilis K‐state (competence) system requires a positive feedback loop
Open accessAbstract
Summary: High expression of the transcriptional activator ComK occurs in 10–20% of the cells in stationary phase cultures of Bacillus subtilis strain 168. ComK drives the expression of more than 100 genes constituting the semidormant K‐state, distinct from sporulation and vegetative growth. Among the genes so activated are those that permit competence for genetic transformation. We have addressed the origin of bistability in expression of ComK. We show that bistability requires positive autoregulation at the promoter of comK , but not a potential toggle switch, in which ComK represses the promoter of rok and Rok represses the promoter of comK . We further address the source of the noise that results in the stochastic selection of cells that will express comK . A revised model for the regulation of comK expression is proposed that partially explains bistability.
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Cites
Stochastic Gene Expression in a Single Cell
Elowitz, M. B., Levine, A. J., Siggia, E. D., & Swain, P. S. (2002) · Science · doi:10.1126/science.1070919 · Cited by 5,441
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952
Intrinsic and extrinsic contributions to stochasticity in gene expression
Swain, P. S., Elowitz, M. B., & Siggia, E. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162041399 · Cited by 1,661
ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON
Novick, A., & Weiner, M. (1957) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.43.7.553 · Cited by 891
Cited by
Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences
Raj, A., & van Oudenaarden, A. (2008) · Cell · doi:10.1016/j.cell.2008.09.050 · Cited by 2,593
Stochastic mRNA Synthesis in Mammalian Cells
Raj, A., Peskin, C. S., Tranchina, D., Vargas, D. Y., & Tyagi, S. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040309 · Cited by 1,737
Noise in Gene Expression Determines Cell Fate in Bacillus subtilis
Maamar, H., Raj, A., & Dubnau, D. (2007) · Science · doi:10.1126/science.1140818 · Cited by 663
Self-citationMicrobial Cell Individuality and the Underlying Sources of Heterogeneity
Avery, S. V. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1460 · Cited by 521
Molecular control of bacterial death and lysis
Rice, K. C., & Bayles, K. W. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00030-07 · Cited by 362
Metadata
- Authors
- Maamar, H., & Dubnau, D.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2005-03-15
- Volume
- 56
- Issue
- 3
- Pages
- 615-624
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2130127788
- Cited by
- 300
- References
- 4
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Maamar, H., & Dubnau, D. (2005). Bistability in the Bacillus subtilis K‐state (competence) system requires a positive feedback loop. Molecular Microbiology. https://doi.org/10.1111/j.1365-2958.2005.04592.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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